Logan Rolls
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loganrolls.bsky.social
Logan Rolls
@loganrolls.bsky.social
BRC-Fleming PhD candidate at Imperial College London and the University of Oxford | Based in Wigneshweraraj Lab | Previously with hintonlab.com
Reposted by Logan Rolls
An important point — colonies growing on agar continue to evolve… We found something similar when isolating plasmid transconjugants: the colonies had already acquired compensatory mutations, reducing the fitness impact of a costly plasmid www.microbiologyresearch.org/content/jour...
November 21, 2024 at 4:37 PM
Reposted by Logan Rolls
Wild-type Salmonella Typhimurium uses PgtE protease to evade C3-mediated serum killing:

Suggests that after escape from a macrophage, PgtE promotes systemic spread of the pathogen…

Elegant work from @manuelar.bsky.social’s team at UCSD…

www.biorxiv.org/content/10.1...
PgtE protease enables virulent Salmonella to evade C3-mediated serum and neutrophil killing
Non-typhoidal Salmonella serovars, such as Salmonella enterica serovar Typhimurium (STm), are a leading cause of inflammatory diarrhea in otherwise healthy individuals. Among children, the elderly, an...
www.biorxiv.org
November 23, 2024 at 1:45 PM