@llidiavasilieva.bsky.social
Reposted
Cell signaling meets gene transcription: Receptor tyrosine kinases directly regulate RNA polymerase II in the nucleus @science.org @stjuderesearch.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
November 6, 2025 at 10:56 PM
Cell signaling meets gene transcription: Receptor tyrosine kinases directly regulate RNA polymerase II in the nucleus @science.org @stjuderesearch.bsky.social
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted
Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II
Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II
Dai et al. show that the transcription elongation factor ELOF1 stabilizes paused RNAPII on chromatin at various transcription barriers. The ELOF1-associated RNAPII allows the recruitment of AID to initiate transcription-coupled damage at its physiological and pathological genomic targets in activated B lymphocytes.
dlvr.it
April 4, 2025 at 7:14 PM
Transcription-coupled AID deamination damage depends on ELOF1-associated RNA polymerase II
Reposted
Fascinated by molecular switches that transition cell states and coordinate transcription. Was a privilege to preview the Singer lab's latest in Molecular Cell, describing how the multitasker BRD4 transitions from a chromatin remodeler to a transcription activator. doi.org/10.1016/j.mo...
November 21, 2024 at 5:34 PM
Fascinated by molecular switches that transition cell states and coordinate transcription. Was a privilege to preview the Singer lab's latest in Molecular Cell, describing how the multitasker BRD4 transitions from a chromatin remodeler to a transcription activator. doi.org/10.1016/j.mo...
Reposted
Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an anti-pausing transcription elongation factor bit.ly/4pbUQzQ
November 17, 2025 at 12:57 PM
Conserved protein Seb1 that interacts with RNA polymerase II and RNA is an anti-pausing transcription elongation factor bit.ly/4pbUQzQ
Reposted
The Glc7/PP1 phosphatase triggers Paf1C dissociation from RNA polymerase II to enable transcription termination https://www.biorxiv.org/content/10.1101/2025.09.03.674035v1
September 3, 2025 at 9:17 PM
The Glc7/PP1 phosphatase triggers Paf1C dissociation from RNA polymerase II to enable transcription termination https://www.biorxiv.org/content/10.1101/2025.09.03.674035v1
Reposted
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
A role for human senataxin in contending with pausing and backtracking during transcript elongation
Senataxin (SETX) regulates RNA polymerase II (RNAPII) transcription and helps maintain genome stability, at least partly by suppressing R-loops. Howev…
www.sciencedirect.com
November 12, 2025 at 5:36 PM
I’m very happy to share Zhong Han’s beautiful work on the biochemical function of Senataxin, encoded by a gene that is mutated in rare and early-disabling neurodegenerative diseases. Turns out it rescues backtracked RNA polymerase II during early transcription! www.sciencedirect.com/science/arti...
@biorxivpreprint.bsky.social
Happy to share our pre-print: The PP1 phosphatase complex coordinates pre-mRNA 3'end processing and termination of RNA polymerase II transcription www.biorxiv.org/content/10.6...
Happy to share our pre-print: The PP1 phosphatase complex coordinates pre-mRNA 3'end processing and termination of RNA polymerase II transcription www.biorxiv.org/content/10.6...
The PP1 phosphatase complex coordinates pre-mRNA 3׳end processing and termination of RNA polymerase II transcription
Phosphorylation plays a central role in coordinating transcription with pre-mRNA maturation, yet the mechanistic understanding of how transcription is regulated by phosphorylation remains limited. The...
www.biorxiv.org
December 18, 2025 at 5:10 PM
@biorxivpreprint.bsky.social
Happy to share our pre-print: The PP1 phosphatase complex coordinates pre-mRNA 3'end processing and termination of RNA polymerase II transcription www.biorxiv.org/content/10.6...
Happy to share our pre-print: The PP1 phosphatase complex coordinates pre-mRNA 3'end processing and termination of RNA polymerase II transcription www.biorxiv.org/content/10.6...