@ljthompsonphd.bsky.social
Immunologist and iPSC/cell therapy scientist
Key development for advancing the promise of Treg therapies: www.science.org/doi/10.1126/...
Generating functionally stable and antigen-specific Treg cells from effector T cells for cell therapy of inflammatory diseases
Antigen-specific and functionally stable Treg cells can be generated in vitro from effector/memory T cells for cell therapy of inflammatory diseases.
www.science.org
October 24, 2025 at 7:56 PM
Key development for advancing the promise of Treg therapies: www.science.org/doi/10.1126/...
Reposted
Our new publication in @cp-immunity.bsky.social: Tertiary lymphoid structures with signs of functional adaptive immune responses in a subset of human gliomas. Association with longer overall patient survival and more immune-permissive tumor microenvironment.
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
October 22, 2025 at 7:36 AM
Our new publication in @cp-immunity.bsky.social: Tertiary lymphoid structures with signs of functional adaptive immune responses in a subset of human gliomas. Association with longer overall patient survival and more immune-permissive tumor microenvironment.
doi.org/10.1016/j.im...
doi.org/10.1016/j.im...
Beautiful work here showing modulation of primary human T cells by transient regulation with multiplexed epigenetic editors: www.nature.com/articles/s41...
Integrated epigenetic and genetic programming of primary human T cells - Nature Biotechnology
Multiplexed editing in primary human T cells generates enhanced immune cell therapies.
www.nature.com
October 23, 2025 at 4:06 PM
Beautiful work here showing modulation of primary human T cells by transient regulation with multiplexed epigenetic editors: www.nature.com/articles/s41...
Reposted
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks - Nature Genetics
Massively parallel reporter assay in primary human CD4+ T cells and bulk and single-cell CRISPR-interference screens identify candidate causal variants linked to autoimmune disease risk that modulate ...
www.nature.com
September 18, 2025 at 8:50 PM
Excited to finally present the lab's latest work in defining candidate causal genetic variants that drive autoimmune diseases and their effects on primary human T cell expression and function! www.nature.com/articles/s41...