@linusschumacher.bsky.social
Cobbling together data and models at the Centre for Regenerative Medicine in Edinburgh. Interested in the collective behaviour of cells in development and regeneration, and better ways of sciencing.
Pinned
Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
Precision Medicine Project - Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
usher.ed.ac.uk
Interested in using your quantitative, computational, and theoretical skills to research better ways to treat human diseases?
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Reposted
Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month!
A limited number of bursaries are available.
p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂
A limited number of bursaries are available.
p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂
The 2025 European Summer School in Stem Cell Biology and Regenerative Medicine will take place 12-19 Sept 2025, on the beautiful Greek island of Spetses.
Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀
Deadline for applications: 30th May 2025
Keep an eye on our website www.stemcellsummerschool.org for updates, or give us a follow 😀
Deadline for applications: 30th May 2025
May 2, 2025 at 2:50 PM
Reminder: deadline to apply for the Stem Cell Summer School is 30th May. And it's May already! So you have to apply this month!
A limited number of bursaries are available.
p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂
A limited number of bursaries are available.
p.s. this year, the summer school coincides with the Spetses Armata Festival, so there will be a big party on the island 🙂
Reposted
Fully-funded PhD opportunity in mathematical biology and applied mathematics with Pascal Buenzli and me at Queensland University of Technology in Brisbane, Australia. Details at smb.org/Member-Forum... @smbmathbiology.bsky.social
March 18, 2025 at 6:06 AM
Fully-funded PhD opportunity in mathematical biology and applied mathematics with Pascal Buenzli and me at Queensland University of Technology in Brisbane, Australia. Details at smb.org/Member-Forum... @smbmathbiology.bsky.social
Reposted
Our framework enables more accurate prediction of CH's clinical impact, moving us closer to personalized risk assessment and potential intervention strategies.
March 7, 2025 at 1:10 PM
Our framework enables more accurate prediction of CH's clinical impact, moving us closer to personalized risk assessment and potential intervention strategies.
Reposted
MACS120 outperformed traditional measurements (like variant allele frequency) in predicting mortality risk and showed increased correlations with the speed of change in blood markers like lymphocyte and albumin levels.
March 7, 2025 at 1:10 PM
MACS120 outperformed traditional measurements (like variant allele frequency) in predicting mortality risk and showed increased correlations with the speed of change in blood markers like lymphocyte and albumin levels.
Reposted
Considering these factors, we developed MACS120 - a novel metric that combines mutation fitness and acquisition timing to predict maximum clone size a mutation will reach over a lifetime.
March 7, 2025 at 1:10 PM
Considering these factors, we developed MACS120 - a novel metric that combines mutation fitness and acquisition timing to predict maximum clone size a mutation will reach over a lifetime.
Reposted
Third, we discovered a strong correlation between mutation timing, or age at time of mutation acquisition (ATMA), and fitness. Higher fitness mutations tend to appear later in life - possibly due to declining quality control mechanisms with age.
March 7, 2025 at 1:10 PM
Third, we discovered a strong correlation between mutation timing, or age at time of mutation acquisition (ATMA), and fitness. Higher fitness mutations tend to appear later in life - possibly due to declining quality control mechanisms with age.
Reposted
Similarly, mutations can have different fitness effects depending on what other mutations are present in the same clone. For example, ASXL1 mutations have higher fitness when co-occurring with SRSF2 than with TET2.
March 7, 2025 at 1:10 PM
Similarly, mutations can have different fitness effects depending on what other mutations are present in the same clone. For example, ASXL1 mutations have higher fitness when co-occurring with SRSF2 than with TET2.
Reposted
Second, we found that clonal coexistence matters! Mutations don't grow in isolation - when multiple clones are present in the same person, they alter each other's overall contribution to the production of blood cells.
March 7, 2025 at 1:10 PM
Second, we found that clonal coexistence matters! Mutations don't grow in isolation - when multiple clones are present in the same person, they alter each other's overall contribution to the production of blood cells.
Reposted
First, we confirmed gene-specific fitness differences: RNA splicing mutations (like U2AF1, U2AF2) show higher fitness than epigenetic regulator mutations (like DNMT3A, TET2).
March 7, 2025 at 1:10 PM
First, we confirmed gene-specific fitness differences: RNA splicing mutations (like U2AF1, U2AF2) show higher fitness than epigenetic regulator mutations (like DNMT3A, TET2).
Reposted
Our key insight: Three factors, mutation fitness (growth advantage), mutation timing, and clonal structure (which mutations occur together) are needed to understand the progression and clinical impact of CH.
March 7, 2025 at 1:10 PM
Our key insight: Three factors, mutation fitness (growth advantage), mutation timing, and clonal structure (which mutations occur together) are needed to understand the progression and clinical impact of CH.
Reposted
We integrated data from 713 individuals across 3 longitudinal aging cohorts (2,341 observations total) and developed models to understand the dynamics of CH mutations over time. #CancerResearch #ClonalHematopoiesis
March 7, 2025 at 1:10 PM
We integrated data from 713 individuals across 3 longitudinal aging cohorts (2,341 observations total) and developed models to understand the dynamics of CH mutations over time. #CancerResearch #ClonalHematopoiesis
Reposted
Clonal hematopoiesis (CH) is common in aging populations and associated with increased risk of blood cancers and other diseases. But what determines which CH mutations will progress to disease?
March 7, 2025 at 1:10 PM
Clonal hematopoiesis (CH) is common in aging populations and associated with increased risk of blood cancers and other diseases. But what determines which CH mutations will progress to disease?
It's great to see the follow-up to our 2022 study on mutations in ageing blood out on bioRxiv, lead by the talented @elatorre.bsky.social – it was a pleasure to work with you again.
TUTORIAL: Our new preprint "Clinical progression of clonal hematopoiesis is determined by a combination of mutation timing, fitness, and clonal structure" is out @elatorre.bsky.social @edinunilbc.bsky.social @linusschumacher.bsky.social @biologyaging.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
www.biorxiv.org
March 7, 2025 at 1:13 PM
It's great to see the follow-up to our 2022 study on mutations in ageing blood out on bioRxiv, lead by the talented @elatorre.bsky.social – it was a pleasure to work with you again.
Reposted
Matt Towers & Alex Fletcher are advertising a fully funded PhD project to investigate feather development in @drn-sheffield.bsky.social at @sheffielduni.bsky.social 🐥🦈🔬
Come join us - it'll be a super cool project!
Send me a message if you have any questions 🧪
www.findaphd.com/phds/project...
Come join us - it'll be a super cool project!
Send me a message if you have any questions 🧪
www.findaphd.com/phds/project...
Investigating a polarity switch in bird wing feather development at University of Sheffield on FindAPhD.com
PhD Project - Investigating a polarity switch in bird wing feather development at University of Sheffield, listed on FindAPhD.com
www.findaphd.com
March 5, 2025 at 10:56 AM
Matt Towers & Alex Fletcher are advertising a fully funded PhD project to investigate feather development in @drn-sheffield.bsky.social at @sheffielduni.bsky.social 🐥🦈🔬
Come join us - it'll be a super cool project!
Send me a message if you have any questions 🧪
www.findaphd.com/phds/project...
Come join us - it'll be a super cool project!
Send me a message if you have any questions 🧪
www.findaphd.com/phds/project...
Reposted
Nominations sought for the 2026 SIAM Activity Group on Life Sciences Early Career Prize!
Deadline May 1, 2025.
Eligibility criteria and more information: www.siam.org/programs-ini...
Deadline May 1, 2025.
Eligibility criteria and more information: www.siam.org/programs-ini...
SIAM Activity Group on Life Sciences Early Career Prize | SIAM
Established in 2016, the prize is awarded to an individual in their early career for research contributions in the field of mathematics applied to the life sciences.
www.siam.org
February 25, 2025 at 10:50 PM
Nominations sought for the 2026 SIAM Activity Group on Life Sciences Early Career Prize!
Deadline May 1, 2025.
Eligibility criteria and more information: www.siam.org/programs-ini...
Deadline May 1, 2025.
Eligibility criteria and more information: www.siam.org/programs-ini...
Reposted
The 2025 Stem Cell Summer School! We get outstanding feedback each year & should probably update our testimonials page 🙃
www.stemcellsummerschool.org/testimonials
This is an advanced course for experienced PhD students (2nd yr & up), postdocs & Junior PIs
It will be great.
Please spread the word
www.stemcellsummerschool.org/testimonials
This is an advanced course for experienced PhD students (2nd yr & up), postdocs & Junior PIs
It will be great.
Please spread the word
February 12, 2025 at 9:01 AM
The 2025 Stem Cell Summer School! We get outstanding feedback each year & should probably update our testimonials page 🙃
www.stemcellsummerschool.org/testimonials
This is an advanced course for experienced PhD students (2nd yr & up), postdocs & Junior PIs
It will be great.
Please spread the word
www.stemcellsummerschool.org/testimonials
This is an advanced course for experienced PhD students (2nd yr & up), postdocs & Junior PIs
It will be great.
Please spread the word
7 days left to apply for @ai4bicdt.bsky.social PhD project with me, Guillaume Blin @edinuni-irr.bsky.social and Peter Humphreys
Join us to advance scientific machine learning methods for biomedical discovery science
www.ai4biomed.io/research/pro...
Join us to advance scientific machine learning methods for biomedical discovery science
www.ai4biomed.io/research/pro...
Projects for 2025 entry – UKRI AI CDT in Biomedical Innovation
www.ai4biomed.io
January 13, 2025 at 12:10 PM
7 days left to apply for @ai4bicdt.bsky.social PhD project with me, Guillaume Blin @edinuni-irr.bsky.social and Peter Humphreys
Join us to advance scientific machine learning methods for biomedical discovery science
www.ai4biomed.io/research/pro...
Join us to advance scientific machine learning methods for biomedical discovery science
www.ai4biomed.io/research/pro...
Only 3 days left to apply for these PhD projects in Edinburgh
Interested in using your quantitative, computational, and theoretical skills to research better ways to treat human diseases?
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
Precision Medicine Project - Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
usher.ed.ac.uk
January 10, 2025 at 3:44 PM
Only 3 days left to apply for these PhD projects in Edinburgh
How does regulation of stem cell proliferation interplay with multistate dynamics?
I'm chuffed to have my first PhD student Rodrigo García-Tejera's second article (with me) published in @dev-journal.bsky.social, great collaboration with @amoyellab.bsky.social and Ramon Grima.
I'm chuffed to have my first PhD student Rodrigo García-Tejera's second article (with me) published in @dev-journal.bsky.social, great collaboration with @amoyellab.bsky.social and Ramon Grima.
Licensing and niche competition in spermatogenesis: mathematical models suggest complementary regulation of tissue maintenance
Read this Research Article by Rodrigo García-Tejera, @amoyellab.bsky.social, @linusschumacher.bsky.social @edinuni-irr.bsky.social & co.
https://doi.org/10.1242/dev.202796
Read this Research Article by Rodrigo García-Tejera, @amoyellab.bsky.social, @linusschumacher.bsky.social @edinuni-irr.bsky.social & co.
https://doi.org/10.1242/dev.202796
January 8, 2025 at 10:45 AM
How does regulation of stem cell proliferation interplay with multistate dynamics?
I'm chuffed to have my first PhD student Rodrigo García-Tejera's second article (with me) published in @dev-journal.bsky.social, great collaboration with @amoyellab.bsky.social and Ramon Grima.
I'm chuffed to have my first PhD student Rodrigo García-Tejera's second article (with me) published in @dev-journal.bsky.social, great collaboration with @amoyellab.bsky.social and Ramon Grima.
Reposted
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
PI programme | Development | The Company of Biologists
PI programme | Development | The Company of Biologists
Development's Pathway to Independence programme
Development is excited to announce our call for our Pathway to Independence program...
journals.biologists.com
December 4, 2024 at 9:37 AM
Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Know a #devbio post-doc about to enter the academic job market?
Would they benefit from a little support & mentoring?
Spread the word
Deadline 31 Jan 2025
journals.biologists.com/dev/pages/pi...
Reposted
I must admit that this annotated Nature abstract remains a useful recipe for constructing a summary paragraph. I show it to my students every time we get started.
November 19, 2024 at 4:42 PM
I must admit that this annotated Nature abstract remains a useful recipe for constructing a summary paragraph. I show it to my students every time we get started.
Interested in using your quantitative, computational, and theoretical skills to research better ways to treat human diseases?
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
Precision Medicine Project - Mathematical modeling of pancreatic islet behaviour for the improvement of islet transplants in Type 1 Diabetes
usher.ed.ac.uk
November 12, 2024 at 3:52 PM
Interested in using your quantitative, computational, and theoretical skills to research better ways to treat human diseases?
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
Apply for a Precision Medicine PhD in Edinburgh!
There are 3 projects with me:
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...
usher.ed.ac.uk/precision-me...