Li Tai Fang
@lethalfang.bsky.social
Genomic bioinformatics scientist. I maintain SomaticSeq as a hobby https://github.com/bioinform/somaticseq
Tough-on-crime, pro-meritocracy, anti-woke, anti-fascist centrist Democrat.
Continue kicking putin's nazi ass.
Tough-on-crime, pro-meritocracy, anti-woke, anti-fascist centrist Democrat.
Continue kicking putin's nazi ass.
Reposted by Li Tai Fang
This is the real issue using sea water. They don't have the ability to draw it in large quantities, not because they don't want to because of corrosion or environmental concerns.
January 14, 2025 at 11:14 PM
This is the real issue using sea water. They don't have the ability to draw it in large quantities, not because they don't want to because of corrosion or environmental concerns.
Corrosion takes a while to kick in while there is a $100B urban fire going on. The cost-benefit isn't even close.
January 14, 2025 at 11:13 PM
Corrosion takes a while to kick in while there is a $100B urban fire going on. The cost-benefit isn't even close.
Salt damage to the roads? Did you see fire damage to the roads?
January 14, 2025 at 5:55 AM
Salt damage to the roads? Did you see fire damage to the roads?
I bet you don’t do that for every paper you’ve come across.
January 4, 2025 at 7:31 PM
I bet you don’t do that for every paper you’ve come across.
We just need to give putin a..... what's that again... off ramp?
December 20, 2024 at 8:39 PM
We just need to give putin a..... what's that again... off ramp?
Reposted by Li Tai Fang
Great episode. I was very confused about this derogatory term “fishing expedition” when I started working with biologists. Was Galileo on a fishing expedition when he discovered the moons of Jupiter?
December 19, 2024 at 1:44 PM
Great episode. I was very confused about this derogatory term “fishing expedition” when I started working with biologists. Was Galileo on a fishing expedition when he discovered the moons of Jupiter?
Make Apartheid Great Again
December 20, 2024 at 6:56 PM
Make Apartheid Great Again
If you're a pharma coming up with a cure for cancer, it would be REALLY bad for every other pharma who just lost ALL of their revenues because they don't have a competitive product.
December 20, 2024 at 8:54 AM
If you're a pharma coming up with a cure for cancer, it would be REALLY bad for every other pharma who just lost ALL of their revenues because they don't have a competitive product.
Only elite VDVs get them.
December 15, 2024 at 10:23 PM
Only elite VDVs get them.
Yeah, it also depends if you're looking for a specific mutation (e.g., a drug target so you have to follow up with an orthogonal technology), or simply estimating a mutation count (e.g., tumor mutation burden).
December 14, 2024 at 5:59 AM
Yeah, it also depends if you're looking for a specific mutation (e.g., a drug target so you have to follow up with an orthogonal technology), or simply estimating a mutation count (e.g., tumor mutation burden).
I think there are 50 bins, so if you add up: height x (1/50), they should add up to one.
December 14, 2024 at 5:53 AM
I think there are 50 bins, so if you add up: height x (1/50), they should add up to one.
The actual BQs aren't represented in the right-hand figure. It just says in false positives, there is more of a difference in variant vs. reference-supporting reads.
December 14, 2024 at 5:45 AM
The actual BQs aren't represented in the right-hand figure. It just says in false positives, there is more of a difference in variant vs. reference-supporting reads.
And the fig on the right is like, if your BQs are 30, it's okay if it's 30 for both variant- and reference-supporting reads. But if it's 30 for variant-supporting reads but 38 for ref-supporting reads, then that is a problem.
December 14, 2024 at 3:59 AM
And the fig on the right is like, if your BQs are 30, it's okay if it's 30 for both variant- and reference-supporting reads. But if it's 30 for variant-supporting reads but 38 for ref-supporting reads, then that is a problem.
Yeah, for a somatic mutation (much rarer than germline variants), you'd want the average BQs to be at around >=35 to be confident.
December 14, 2024 at 3:52 AM
Yeah, for a somatic mutation (much rarer than germline variants), you'd want the average BQs to be at around >=35 to be confident.