Leslie Day, PhD
@lesliedaymicro.bsky.social
Anaerobic Microbiologist
Damon Runyon Fellow
Postdoc @ O’Toole Lab, Dartmouth
Damon Runyon Fellow
Postdoc @ O’Toole Lab, Dartmouth
Reposted by Leslie Day, PhD
Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes
www.biorxiv.org/content/10.1... #jcampubs
www.biorxiv.org/content/10.1... #jcampubs
November 7, 2025 at 3:13 PM
Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes
www.biorxiv.org/content/10.1... #jcampubs
www.biorxiv.org/content/10.1... #jcampubs
Reposted by Leslie Day, PhD
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus - PubMed
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergisti …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:38 PM
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
November 6, 2025 at 9:14 PM
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
Reposted by Leslie Day, PhD
Congratulations to Bassam el Hafi, who successfully defended his PhD thesis yesterday! He did a terrific job! Bassam connected microbial interactions to the complexity of human communication. Thanks also to Sarah Clark of the Anschutz School of Medicine who served at Bassam's outside examiner.
November 6, 2025 at 1:44 PM
Congratulations to Bassam el Hafi, who successfully defended his PhD thesis yesterday! He did a terrific job! Bassam connected microbial interactions to the complexity of human communication. Thanks also to Sarah Clark of the Anschutz School of Medicine who served at Bassam's outside examiner.
Reposted by Leslie Day, PhD
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 30, 2025 at 12:42 PM
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Leslie Day, PhD
We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.
October 28, 2025 at 1:47 PM
We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.
Reposted by Leslie Day, PhD
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
October 7, 2025 at 8:32 PM
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
Reposted by Leslie Day, PhD
Earlier this month, we proudly welcomed the newest cohort of Damon Runyon Fellows! These 16 brilliant postdocs will receive four years of independent funding to advance their investigation of causes, treatments, and prevention strategies for all types of cancer. Read more: https://bit.ly/4nc25Hq
September 19, 2025 at 4:54 PM
Earlier this month, we proudly welcomed the newest cohort of Damon Runyon Fellows! These 16 brilliant postdocs will receive four years of independent funding to advance their investigation of causes, treatments, and prevention strategies for all types of cancer. Read more: https://bit.ly/4nc25Hq
Reposted by Leslie Day, PhD
In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1
September 24, 2025 at 6:13 PM
In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1
Reposted by Leslie Day, PhD
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Pseudomonas aeruginosa supports the survival of Prevotella melaninogenica in a cystic fibrosis lung polymicrobial community through metabolic cross-feeding | mBio
Polymicrobial interactions impact disease outcomes in pwCF who suffer from chronic
respiratory infections. Previous work established a CF-relevant polymicrobial community
model that allows experimenta...
journals.asm.org
September 12, 2025 at 6:46 PM
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Reposted by Leslie Day, PhD
Excited to share our latest work, driven by my recently graduated PhD student Kaitlyn Barrack, exploring the mechanisms of bacterial dysbiosis in the CF gut - including a role for a colorectal cancer-associated genotoxin in this competition.
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
September 5, 2025 at 12:57 PM
Excited to share our latest work, driven by my recently graduated PhD student Kaitlyn Barrack, exploring the mechanisms of bacterial dysbiosis in the CF gut - including a role for a colorectal cancer-associated genotoxin in this competition.
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
www.biorxiv.org/content/10.1...
@kbarrack.bsky.social
Reposted by Leslie Day, PhD
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
September 5, 2025 at 12:21 PM
Excited about our most recent collaboration with the Wong lab, lead by William Schmidt, describing a T4P and CdrA-mediated mechanism of sensing surface EPS. Fun stuff and great work William and team.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Leslie Day, PhD
The latest and greatest from an amazing team of authors. See what you think:
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds - Stern - 2025 - Journal of Geophysical Research: Planets - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds - Stern - 2025 - Journal of Geophysical Research: Planets - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds
The choice of analogue field site for ocean worlds research requires traceability to a well-developed science question We present a two-step process to evaluate field sites with respect to their ...
agupubs.onlinelibrary.wiley.com
September 5, 2025 at 10:31 PM
The latest and greatest from an amazing team of authors. See what you think:
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds - Stern - 2025 - Journal of Geophysical Research: Planets - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...
A Comprehensive Framework for Assessing Terrestrial Analogue Field Sites for Ocean Worlds - Stern - 2025 - Journal of Geophysical Research: Planets - Wiley Online Library agupubs.onlinelibrary.wiley.com/doi/10.1029/...
Incredibly honored to be a Damon Runyon Fellow! @damonrunyon.org
I'm very excited to report that Leslie Day, a post doc in the lab, was awarded a Damon Runyon Cancer Research Fund post-doctoral fellowship to support her work over the next 4 years! Congrats to Leslie!
tinyurl.com/3p26njb6
tinyurl.com/3p26njb6
September 6, 2025 at 3:44 AM
Incredibly honored to be a Damon Runyon Fellow! @damonrunyon.org
Reposted by Leslie Day, PhD
Our newest manuscript on the gut-lung axis in CF, lead by Rebecca Valls, explores sex and intestinal regional differences in response to Bacteroides. Check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
August 28, 2025 at 12:10 PM
Our newest manuscript on the gut-lung axis in CF, lead by Rebecca Valls, explores sex and intestinal regional differences in response to Bacteroides. Check it out!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Leslie Day, PhD
We had the O'Toole Lab Reunion on Sat here at Dartmouth, celebrating 26 amazing years - science is all about the people, and I have been fortunate to have a great bunch of folks in the lab over the years! And THANKS to all the lab members who did all the organizing!
August 25, 2025 at 7:13 PM
We had the O'Toole Lab Reunion on Sat here at Dartmouth, celebrating 26 amazing years - science is all about the people, and I have been fortunate to have a great bunch of folks in the lab over the years! And THANKS to all the lab members who did all the organizing!
Reposted by Leslie Day, PhD
Microbes rarely exist alone; instead, they live in dynamic communities. In #IAIJournal, researchers discuss the interplay between the host environment & microbiome metabolism & the impacts on disease progression in host-associated polymicrobial communities. asm.social/2yf
August 20, 2025 at 5:56 PM
Microbes rarely exist alone; instead, they live in dynamic communities. In #IAIJournal, researchers discuss the interplay between the host environment & microbiome metabolism & the impacts on disease progression in host-associated polymicrobial communities. asm.social/2yf
Reposted by Leslie Day, PhD
Excited about our most recent paper lead by Kaitlyn Barrack, a minireview in JB comparing the CF and IBD guts - from microbiomes to physiologies. There are many similarities...
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology @kbarrack.bsky.social
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology @kbarrack.bsky.social
August 18, 2025 at 4:11 PM
Excited about our most recent paper lead by Kaitlyn Barrack, a minireview in JB comparing the CF and IBD guts - from microbiomes to physiologies. There are many similarities...
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology @kbarrack.bsky.social
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology @kbarrack.bsky.social
Reposted by Leslie Day, PhD
✨Our annual #BiofilmCreate Competition is open for 2025!
🎨 📷 Showcase your talent in #photography / #art whilst highlighting the impact of #biofilms
🏆Gift cards will be awarded in both categories
🗳️biofilms.ac.uk/create
#science #scicomm #AMR #MicroSky
🎨 📷 Showcase your talent in #photography / #art whilst highlighting the impact of #biofilms
🏆Gift cards will be awarded in both categories
🗳️biofilms.ac.uk/create
#science #scicomm #AMR #MicroSky
August 11, 2025 at 12:03 PM
✨Our annual #BiofilmCreate Competition is open for 2025!
🎨 📷 Showcase your talent in #photography / #art whilst highlighting the impact of #biofilms
🏆Gift cards will be awarded in both categories
🗳️biofilms.ac.uk/create
#science #scicomm #AMR #MicroSky
🎨 📷 Showcase your talent in #photography / #art whilst highlighting the impact of #biofilms
🏆Gift cards will be awarded in both categories
🗳️biofilms.ac.uk/create
#science #scicomm #AMR #MicroSky
Microbial Diversity 💜
August 3, 2025 at 4:19 PM
Microbial Diversity 💜
Reposted by Leslie Day, PhD
JB Editor's Choice: Our latest in the Microbial Model Systems series (journals.asm.org/topic/sss-ta...) is "Milestones in the development of Myxococcus xanthus as a model multicellular bacterium" - from many contributors!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
August 1, 2025 at 2:48 PM
JB Editor's Choice: Our latest in the Microbial Model Systems series (journals.asm.org/topic/sss-ta...) is "Milestones in the development of Myxococcus xanthus as a model multicellular bacterium" - from many contributors!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
@amnh.org pleaaaseeeeee let me help update this! Everything else about the biodiversity room is amazing but this hurt my archaea loving soul.
July 25, 2025 at 7:36 PM
@amnh.org pleaaaseeeeee let me help update this! Everything else about the biodiversity room is amazing but this hurt my archaea loving soul.
Reposted by Leslie Day, PhD
"Respiratory viral infection is associated with increased Pseudomonas abundance in cystic fibrosis airways"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Respiratory viral infection is associated with increased Pseudomonas abundance in cystic fibrosis airways
Acute respiratory viral infections are an important driver of morbidity and mortality in people with chronic lung disease and are frequently associated with pulmonary exacerbations and a transition fr...
www.biorxiv.org
July 21, 2025 at 1:18 PM
"Respiratory viral infection is associated with increased Pseudomonas abundance in cystic fibrosis airways"
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Leslie Day, PhD
Last night at Microbial Diversity, we all went out for a MD tradition- the Volta experiment! A dirty but happy crew!
@mblscience.bsky.social
@mblscience.bsky.social
July 8, 2025 at 1:14 PM
Last night at Microbial Diversity, we all went out for a MD tradition- the Volta experiment! A dirty but happy crew!
@mblscience.bsky.social
@mblscience.bsky.social