Leslie Day, PhD
@lesliedaymicro.bsky.social
Anaerobic Microbiologist
Damon Runyon Fellow
Postdoc @ O’Toole Lab, Dartmouth
Damon Runyon Fellow
Postdoc @ O’Toole Lab, Dartmouth
Reposted by Leslie Day, PhD
The Microbial Diversity courseis top-notch! Hoping to see you there! www.mbl.edu/education/ad...
January 14, 2026 at 6:44 PM
The Microbial Diversity courseis top-notch! Hoping to see you there! www.mbl.edu/education/ad...
Reposted by Leslie Day, PhD
No one organization can fill the gaps created by federal funding cuts to research. But as an independent funder, Damon Runyon is committed to ensuring that our scientists can continue their lifesaving work in 2026 and beyond. Until midnight, all gifts will be fully matched: damonrunyon.org/donate
Damon Runyon scientists on the impact of slashing research funding
Damon Runyon scientists explain how drastic cuts in federal research funding threaten progress in cancer research, and how Damon Runyon can help protect the breakthroughs…
vimeo.com
December 31, 2025 at 6:07 PM
No one organization can fill the gaps created by federal funding cuts to research. But as an independent funder, Damon Runyon is committed to ensuring that our scientists can continue their lifesaving work in 2026 and beyond. Until midnight, all gifts will be fully matched: damonrunyon.org/donate
Reposted by Leslie Day, PhD
New from AFI researchers Jennifer Gundrum and Drs. Tabita Ramirez-Puebla, Jessica L. Mark Welch, and Gary G. Borisy:
Novel FISH method overcomes cell wall barriers, enabling clearer insight into complex microbial communities.
Learn more: journals.asm.org/doi/10.1128/...
Novel FISH method overcomes cell wall barriers, enabling clearer insight into complex microbial communities.
Learn more: journals.asm.org/doi/10.1128/...
December 23, 2025 at 2:50 PM
New from AFI researchers Jennifer Gundrum and Drs. Tabita Ramirez-Puebla, Jessica L. Mark Welch, and Gary G. Borisy:
Novel FISH method overcomes cell wall barriers, enabling clearer insight into complex microbial communities.
Learn more: journals.asm.org/doi/10.1128/...
Novel FISH method overcomes cell wall barriers, enabling clearer insight into complex microbial communities.
Learn more: journals.asm.org/doi/10.1128/...
Reposted by Leslie Day, PhD
The 2025 Agar Art Contest winners have been selected! This year’s theme, “Microbes Make the World Go Round,” inspired 557 global entries—from food fermentation to antibiotic production. See the masterpieces and finalists! asm.org/press-releas... #agarart
December 15, 2025 at 4:59 PM
The 2025 Agar Art Contest winners have been selected! This year’s theme, “Microbes Make the World Go Round,” inspired 557 global entries—from food fermentation to antibiotic production. See the masterpieces and finalists! asm.org/press-releas... #agarart
@archaeabio.bsky.social can maybe help here?
December 9, 2025 at 1:48 PM
@archaeabio.bsky.social can maybe help here?
Reposted by Leslie Day, PhD
The latest and most detailed review on a fundamental biochemical pathway: #glycolysis
#microbiology #biochemistry
onlinelibrary.wiley.com/doi/full/10....
#microbiology #biochemistry
onlinelibrary.wiley.com/doi/full/10....
December 7, 2025 at 11:01 AM
The latest and most detailed review on a fundamental biochemical pathway: #glycolysis
#microbiology #biochemistry
onlinelibrary.wiley.com/doi/full/10....
#microbiology #biochemistry
onlinelibrary.wiley.com/doi/full/10....
Reposted by Leslie Day, PhD
In a manuscript on BioRxiv, we describe experiments exploring the culturome of the gut of adults with CF and in health, revealing an interesting redistribution of the microbes in the lumen vs. mucosa. The study is led by Sarvesh Surve a PhD student in my lab.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 3, 2025 at 5:21 PM
In a manuscript on BioRxiv, we describe experiments exploring the culturome of the gut of adults with CF and in health, revealing an interesting redistribution of the microbes in the lumen vs. mucosa. The study is led by Sarvesh Surve a PhD student in my lab.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Leslie Day, PhD
Rare Phyla, Such as CPR and DPANN, Shape Ecosystem-Level Microbial Community Structure Dissimilarities link.springer.com/article/10.1... #jcampubs
Rare Phyla, Such as CPR and DPANN, Shape Ecosystem-Level Microbial Community Structure Dissimilarities - Microbial Ecology
Rare microbial lineages, such as members of the candidate phyla radiation (CPR) bacteria and Diapherotrites, Parvarchaeota, Aenigmarchaeota, Nanoarchaeota, and Nanohaloarchaeota (DPANN) archaea, are i...
link.springer.com
December 1, 2025 at 2:34 PM
Rare Phyla, Such as CPR and DPANN, Shape Ecosystem-Level Microbial Community Structure Dissimilarities link.springer.com/article/10.1... #jcampubs
When life gives you lab electrical shutdowns for maintenance … you make the most of the first bits of east coast snow!
November 26, 2025 at 1:44 AM
When life gives you lab electrical shutdowns for maintenance … you make the most of the first bits of east coast snow!
Reposted by Leslie Day, PhD
Very excited to share a big part of my dissertation work with the Deutschbauer lab at LBNL and @ucberkeleyofficial.bsky.social! BarTn7: A method for bacterial lineage tracking at sub-species resolution in population, ecological, and evolutionary experiments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
BarTn7: Optimizing Bacterial Lineage Tracking at Sub-Species Resolution for Population Dynamics in Ecological and Evolutionary Studies
Communities of bacteria undergo population bottlenecks which are crucial to their population, ecological, and evolutionary dynamics. However, conventional amplicon sequencing cannot distinguish such d...
www.biorxiv.org
November 25, 2025 at 10:38 PM
Very excited to share a big part of my dissertation work with the Deutschbauer lab at LBNL and @ucberkeleyofficial.bsky.social! BarTn7: A method for bacterial lineage tracking at sub-species resolution in population, ecological, and evolutionary experiments.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Leslie Day, PhD
Excited to share new work from Sarvesh Surve examining the gut microbiota of adults with CF using colonoscopy samples and a culturomics approach. We note continued depletion of Bacteroidota (which we noted in kids) & enrichment of aerobes in the mucosa of pwCF.
pubmed.ncbi.nlm.nih.gov/41256617/
pubmed.ncbi.nlm.nih.gov/41256617/
November 21, 2025 at 3:09 PM
Excited to share new work from Sarvesh Surve examining the gut microbiota of adults with CF using colonoscopy samples and a culturomics approach. We note continued depletion of Bacteroidota (which we noted in kids) & enrichment of aerobes in the mucosa of pwCF.
pubmed.ncbi.nlm.nih.gov/41256617/
pubmed.ncbi.nlm.nih.gov/41256617/
Reposted by Leslie Day, PhD
DAY 168
SPECIES 168 - Prevotella intermedia
STAGE: Bacteria
MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Sakura pen
Thanks to @lesliedaymicro.bsky.social for suggesting it!
#sciart #watercolor #bacteria #painting #art #paint
SPECIES 168 - Prevotella intermedia
STAGE: Bacteria
MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Sakura pen
Thanks to @lesliedaymicro.bsky.social for suggesting it!
#sciart #watercolor #bacteria #painting #art #paint
November 20, 2025 at 7:34 AM
DAY 168
SPECIES 168 - Prevotella intermedia
STAGE: Bacteria
MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Sakura pen
Thanks to @lesliedaymicro.bsky.social for suggesting it!
#sciart #watercolor #bacteria #painting #art #paint
SPECIES 168 - Prevotella intermedia
STAGE: Bacteria
MEDIUM: Arches Paper. Chromatek & HWC Watercolor. Sakura pen
Thanks to @lesliedaymicro.bsky.social for suggesting it!
#sciart #watercolor #bacteria #painting #art #paint
Reposted by Leslie Day, PhD
Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.
November 17, 2025 at 2:36 PM
Clone-FISH paper out: Manuscript/resource alert #microsky 🦠 We present a collection of 30 E. coli (CloneFISH) cultures, each carrying a plasmid for the heterologous expression of a (near) full-length 16S rRNA gene from one of 30 lineages of archaea, including 17 yet uncultured ones.
Reposted by Leslie Day, PhD
Reposted by Leslie Day, PhD
Assembly, architecture and functional roles of microbial surface layers
#microbiology #archaea #bacteria
@natrevmicro.nature.com
www.nature.com/articles/s41...
#microbiology #archaea #bacteria
@natrevmicro.nature.com
www.nature.com/articles/s41...
Assembly, architecture and functional roles of microbial surface layers - Nature Reviews Microbiology
Surface layers (S-layers) are ubiquitous protein assemblies that coat prokaryotic cells, with their functional roles increasingly coming into focus. In this Review, Isbilir and colleagues discuss rece...
www.nature.com
November 15, 2025 at 10:04 AM
Assembly, architecture and functional roles of microbial surface layers
#microbiology #archaea #bacteria
@natrevmicro.nature.com
www.nature.com/articles/s41...
#microbiology #archaea #bacteria
@natrevmicro.nature.com
www.nature.com/articles/s41...
Reposted by Leslie Day, PhD
Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes
www.biorxiv.org/content/10.1... #jcampubs
www.biorxiv.org/content/10.1... #jcampubs
November 7, 2025 at 3:13 PM
Increased mutation rates and diversity are dominant features of Geobacter multiheme cytochromes
www.biorxiv.org/content/10.1... #jcampubs
www.biorxiv.org/content/10.1... #jcampubs
Reposted by Leslie Day, PhD
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus - PubMed
P. melaninogenica enhanced neutrophil and epithelial defense against S. aureus, but the benefits of epithelial cell regulation by P. melaninogenica were lost with CFTR dysfunction. CFTR modulators rescued P. melaninogenica responsiveness in epithelial cells, highlighting the potential for synergisti …
pubmed.ncbi.nlm.nih.gov
November 7, 2025 at 12:38 PM
"Functional CFTR may be required for Prevotella melaninogenica regulation of epithelial cell defense against Staphylococcus aureus"
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
pubmed.ncbi.nlm.nih.gov/41198444/
#microsky
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
November 6, 2025 at 9:14 PM
Prevotella is the clear favorite of the 4-member cookie community (not like I’m surprised) @bassamhafi.bsky.social @fabricejpierre.bsky.social
Reposted by Leslie Day, PhD
Congratulations to Bassam el Hafi, who successfully defended his PhD thesis yesterday! He did a terrific job! Bassam connected microbial interactions to the complexity of human communication. Thanks also to Sarah Clark of the Anschutz School of Medicine who served at Bassam's outside examiner.
November 6, 2025 at 1:44 PM
Congratulations to Bassam el Hafi, who successfully defended his PhD thesis yesterday! He did a terrific job! Bassam connected microbial interactions to the complexity of human communication. Thanks also to Sarah Clark of the Anschutz School of Medicine who served at Bassam's outside examiner.
Reposted by Leslie Day, PhD
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
October 30, 2025 at 12:42 PM
New in JB: A minireview from my team, led by a recently graduated PhD student Kaitlyn Barrack, compares the microbiota and physiology of the CF gut with features of the gut in inflammatory bowel disease - there are many similarities!
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
journals.asm.org/doi/10.1128/...
@asm.org #JBacteriology
Reposted by Leslie Day, PhD
We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.
October 28, 2025 at 1:47 PM
We're thrilled to announce SeqHub, an AI-enabled platform for biological sequence analysis. SeqHub brings together sequence search, genome annotation, and data sharing in one place.
Reposted by Leslie Day, PhD
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
October 7, 2025 at 8:32 PM
Excited to be part of this collaboration with the Burrows lab exploring twitching and surface surface sensing by P. aeruginosa. This work further delineates a role for the T4P motor proteins and pili for surface sensing.
journals.asm.org/doi/10.1128/...
@asm.org
journals.asm.org/doi/10.1128/...
@asm.org
Reposted by Leslie Day, PhD
Earlier this month, we proudly welcomed the newest cohort of Damon Runyon Fellows! These 16 brilliant postdocs will receive four years of independent funding to advance their investigation of causes, treatments, and prevention strategies for all types of cancer. Read more: https://bit.ly/4nc25Hq
September 19, 2025 at 4:54 PM
Earlier this month, we proudly welcomed the newest cohort of Damon Runyon Fellows! These 16 brilliant postdocs will receive four years of independent funding to advance their investigation of causes, treatments, and prevention strategies for all types of cancer. Read more: https://bit.ly/4nc25Hq
Reposted by Leslie Day, PhD
In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1
September 24, 2025 at 6:13 PM
In #mBio, dive into story behind the 1989 discovery of Helicobacter pylori CagA, the first tumorigenic bacterial protein. This article recounts the early steps in the investigative process and relates some of the unexpected discoveries that ensued. asm.social/2C1
Reposted by Leslie Day, PhD
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...
Pseudomonas aeruginosa supports the survival of Prevotella melaninogenica in a cystic fibrosis lung polymicrobial community through metabolic cross-feeding | mBio
Polymicrobial interactions impact disease outcomes in pwCF who suffer from chronic
respiratory infections. Previous work established a CF-relevant polymicrobial community
model that allows experimenta...
journals.asm.org
September 12, 2025 at 6:46 PM
Happy to finally see this out! Bassam El Halfi (@bassamhafi.bsky.social - my first rotation student when I started my post-doc in @geiselbiofilm.bsky.social) did an amazing job investigating mechanisms of interspecies metabolic interactions. Check it out! #microsky
journals.asm.org/doi/10.1128/...
journals.asm.org/doi/10.1128/...