Lee Grimes Lab
@leegrimeslab.bsky.social
🏳️🌈Molecular Oncology 🧬Hematology 🩸and Immunology at Cincinnati Children's Hospital. interested in understanding how ancestry affects cancer genetics and clinical outcomes.
https://www.cincinnatichildrens.org/research/divisions/i/immunobiology/labs/grimes
https://www.cincinnatichildrens.org/research/divisions/i/immunobiology/labs/grimes
Postdoc Kyle Ferchen figured out how to integrate CITE-seq, TEA-seq and InfinityFlow to link cell surface markers, gene expression, and chromatin accessibility to underlying gene regulatory networks (GRNs). Clusters, gene expression and GRN edges are searchable here: altanalyze.org/MarrowAtlas/...
Bone Marrow Single-Cell Atlas Portal
altanalyze.org
October 22, 2025 at 1:11 PM
Postdoc Kyle Ferchen figured out how to integrate CITE-seq, TEA-seq and InfinityFlow to link cell surface markers, gene expression, and chromatin accessibility to underlying gene regulatory networks (GRNs). Clusters, gene expression and GRN edges are searchable here: altanalyze.org/MarrowAtlas/...
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
A unified multimodal single-cell framework reveals a discrete state model of hematopoiesis in mice
Nature Immunology - Grimes and colleagues integrate multiomic features to create a framework that allows the isolation of discrete cell states across hematopoiesis and exploit the underlying gene...
rdcu.be
October 22, 2025 at 1:10 PM
New “discrete state” model of hematopoiesis published in Nature Immunology. rdcu.be/eL8oO
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
We propose a hierarchical model of hematopoiesis where stable “discrete states” serve as key regulatory nodes.
Reposted by Lee Grimes Lab
With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology
August 19, 2025 at 4:50 PM
With potential NIH budget cuts and funding freezes putting vital work at risk, the ASH Bridge Grant is helping researchers, and their discoveries stay on track to improve patient care. #Fight4Hematology
Reposted by Lee Grimes Lab
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
August 19, 2025 at 4:50 PM
This year the ASH Bridge Grant is funding 25 scientists with $3.75M, 5X more than last year, to keep hematology research moving forward. Congratulations to the recipients! https://bit.ly/3HJ51Ma
#HemeSky #MedSKy #ASHAwards
#HemeSky #MedSKy #ASHAwards
ASH Seeks Fundamental Discovery Science Abstracts for #ASH25
IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25.
Its an experiment!
Submit your cool basic science before August 5, 2025, at 11:59 p.m.
IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25.
Its an experiment!
Submit your cool basic science before August 5, 2025, at 11:59 p.m.
July 16, 2025 at 9:13 PM
ASH Seeks Fundamental Discovery Science Abstracts for #ASH25
IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25.
Its an experiment!
Submit your cool basic science before August 5, 2025, at 11:59 p.m.
IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25.
Its an experiment!
Submit your cool basic science before August 5, 2025, at 11:59 p.m.
ASH is committing more than $12 million to address research funding challenges and support the next generation of hematologists.
Learn more: ow.ly/sK3050W735W
Learn more: ow.ly/sK3050W735W
ASH Commits More than $12 Million to Address Research Threats - Hematology.org
ASH Commits More than $12 Million to Address Research Threats
ow.ly
June 10, 2025 at 3:20 PM
ASH is committing more than $12 million to address research funding challenges and support the next generation of hematologists.
Learn more: ow.ly/sK3050W735W
Learn more: ow.ly/sK3050W735W
ASH has made an unprecedented investment of more than $12 million. Including ~$9 million increase in award funding. Total awards commitment of more than $20 million over the next 12 months....providing support for an additional 600+ awardees at all career stages. @ash.hematology.org
June 10, 2025 at 3:20 PM
ASH has made an unprecedented investment of more than $12 million. Including ~$9 million increase in award funding. Total awards commitment of more than $20 million over the next 12 months....providing support for an additional 600+ awardees at all career stages. @ash.hematology.org
ASH Bridge Award direct cost floor was already raised to $500K/yr. Now the number of applications funded is dramatically increasing, with a rapid turn around...and a brand new additional cycle this year. @ash.hematology.org
June 10, 2025 at 3:19 PM
ASH Bridge Award direct cost floor was already raised to $500K/yr. Now the number of applications funded is dramatically increasing, with a rapid turn around...and a brand new additional cycle this year. @ash.hematology.org
Are you concerned about how to get your trainees to ASH2025 in Orlando? Massive increase in trainee travel awards for those giving poster or oral presentations. Submit those abstracts and find out! @ash.hematology.org
June 10, 2025 at 3:19 PM
Are you concerned about how to get your trainees to ASH2025 in Orlando? Massive increase in trainee travel awards for those giving poster or oral presentations. Submit those abstracts and find out! @ash.hematology.org
Coming soon.....news about increasing fundamental basic science representation at ASH...we are running an experiment!....hope you will participate in ASH2025.
@ash.hematology.org
@ash.hematology.org
June 10, 2025 at 3:18 PM
Coming soon.....news about increasing fundamental basic science representation at ASH...we are running an experiment!....hope you will participate in ASH2025.
@ash.hematology.org
@ash.hematology.org
Feeling like the worst “Rainy Day” has hit your hematology lab?
ASH is deploying some significant umbrellas.
More details soon!
Watch @ash.hematology.org
ASH is deploying some significant umbrellas.
More details soon!
Watch @ash.hematology.org
June 7, 2025 at 3:52 PM
Feeling like the worst “Rainy Day” has hit your hematology lab?
ASH is deploying some significant umbrellas.
More details soon!
Watch @ash.hematology.org
ASH is deploying some significant umbrellas.
More details soon!
Watch @ash.hematology.org
If you are invited to review abstracts for ASH2026 in a basic science category, please know that I reviewed these sections and pushed for you to do this work. PLEASE HELP ME OUT. We want to increase the quality and representation of basic science at ASH.
May 9, 2025 at 3:18 PM
If you are invited to review abstracts for ASH2026 in a basic science category, please know that I reviewed these sections and pushed for you to do this work. PLEASE HELP ME OUT. We want to increase the quality and representation of basic science at ASH.
Reposted by Lee Grimes Lab
New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!
Splicing regulatory dynamics for precision analysis and treatment of heterogeneous leukemias
Broad dysregulated splicing in AML partially phenocopies splicing factor mutations, is prognostic, and can be pharmacologically reversed.
www.science.org
May 7, 2025 at 11:05 PM
New in STM, check out our integrative bulk & single-cell long-read analysis to discover and test new therapies in leukemia. We developed OncoSplice, to define new splicing defined subtypes and predict regulators. PRMT5 inhibition partially rescued mis-splicing & inhibited leukemic growth. More soon!
Reposted by Lee Grimes Lab
The first NIH posting to the Federal Register since the inauguration appeared today. It lists several study section meetings. Great news! www.federalregister.gov/documents/20...
March 4, 2025 at 5:59 PM
The first NIH posting to the Federal Register since the inauguration appeared today. It lists several study section meetings. Great news! www.federalregister.gov/documents/20...
Reposted by Lee Grimes Lab
"A freeze on meetings of expert panels that peer review grant proposals at the NIH is kicking in this week ... Trump barred NIH from posting new Federal Register notices, which means any study section not advertised before then cannot take place." #medsky 🧪
www.science.org/content/arti...
www.science.org/content/arti...
Trump Tracker: Firings, lawsuits, and U.S. science in chaos
Follow President Donald Trump’s impact on U.S. research and science globally
www.science.org
February 20, 2025 at 3:28 PM
"A freeze on meetings of expert panels that peer review grant proposals at the NIH is kicking in this week ... Trump barred NIH from posting new Federal Register notices, which means any study section not advertised before then cannot take place." #medsky 🧪
www.science.org/content/arti...
www.science.org/content/arti...
Here is the FedEx package Linda Wolfe sent me in 2010 which included all the financials for MYELOID when it was the “Annapolis meeting”
Oh my! It’s a lot more expensive these days!
Oh my! It’s a lot more expensive these days!
January 21, 2025 at 8:48 PM
Here is the FedEx package Linda Wolfe sent me in 2010 which included all the financials for MYELOID when it was the “Annapolis meeting”
Oh my! It’s a lot more expensive these days!
Oh my! It’s a lot more expensive these days!
The 15th International Workshop on Molecular Aspects of Myeloid Stem Cell Development, will be held at the Jarson-Kaplan Theater of the Aronoff Center for the Arts in Cincinnati, Ohio on May 18-21, 2026. Please hold these dates on your calendar.
January 21, 2025 at 8:40 PM
The 15th International Workshop on Molecular Aspects of Myeloid Stem Cell Development, will be held at the Jarson-Kaplan Theater of the Aronoff Center for the Arts in Cincinnati, Ohio on May 18-21, 2026. Please hold these dates on your calendar.
Rebecca Black (ask your kids) came to Seacrest Studio and Grimes Lab peeps Connor and Sierra got to say hello!
January 2, 2025 at 2:36 PM
Rebecca Black (ask your kids) came to Seacrest Studio and Grimes Lab peeps Connor and Sierra got to say hello!
Holiday (science) Spirit here at CCHMC in the Hildeman Lab
December 18, 2024 at 5:50 PM
Holiday (science) Spirit here at CCHMC in the Hildeman Lab
December 9, 2024 at 6:20 AM
Reposted by Lee Grimes Lab
Is the survival disparity observed in Black AML patients linked to underlying differences in disease biology? Come learn about PHIP, a previously overlooked oncogene found in Black patients, at my talk tomorrow (12/7) at 4:30🩸 #ASH24 #AML #healthequity @leegrimeslab.bsky.social
December 6, 2024 at 11:30 PM
Is the survival disparity observed in Black AML patients linked to underlying differences in disease biology? Come learn about PHIP, a previously overlooked oncogene found in Black patients, at my talk tomorrow (12/7) at 4:30🩸 #ASH24 #AML #healthequity @leegrimeslab.bsky.social
December 6, 2024 at 3:24 PM
Reposted by Lee Grimes Lab
Hello, #hematology community! ASH is now on BlueSky.
We're here to share cutting-edge research and educational resources and connect global experts in blood diseases.
Join us in advancing hematology together. Welcome, colleagues!
#BloodSky #HemeSky #MedSky
We're here to share cutting-edge research and educational resources and connect global experts in blood diseases.
Join us in advancing hematology together. Welcome, colleagues!
#BloodSky #HemeSky #MedSky
November 21, 2024 at 5:15 PM
Hello, #hematology community! ASH is now on BlueSky.
We're here to share cutting-edge research and educational resources and connect global experts in blood diseases.
Join us in advancing hematology together. Welcome, colleagues!
#BloodSky #HemeSky #MedSky
We're here to share cutting-edge research and educational resources and connect global experts in blood diseases.
Join us in advancing hematology together. Welcome, colleagues!
#BloodSky #HemeSky #MedSky