Lawrence Lynn
@lawrencelynn.bsky.social
Pulmonary and Critical Care Research Physician.
Don’t miss the new discussion of RCT transportability at Vanderbilt’s datamethods site.
What standards should be defined for RCT generalization to clinical guidelines.
What standards should be defined for RCT generalization to clinical guidelines.
Join discussion of “RCT generalizability to clinical guidelines”
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
Generalizability vs. Transportability in Trials
As a clinician I am so happy you are doing this much needed work. The ultimate generalization is the insertion of the results of an RCT into guidelines. This decision to generalize to guidelines has...
discourse.datamethods.org
December 9, 2025 at 6:27 PM
Don’t miss the new discussion of RCT transportability at Vanderbilt’s datamethods site.
What standards should be defined for RCT generalization to clinical guidelines.
What standards should be defined for RCT generalization to clinical guidelines.
Join discussion of “RCT generalizability to clinical guidelines”
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
Generalizability vs. Transportability in Trials
As a clinician I am so happy you are doing this much needed work. The ultimate generalization is the insertion of the results of an RCT into guidelines. This decision to generalize to guidelines has...
discourse.datamethods.org
December 9, 2025 at 5:51 PM
Join discussion of “RCT generalizability to clinical guidelines”
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
Contrast 2 mega RCT with directly opposite results. (The 1st with ~50% rel. improved survival 2nd ~50% rel. reduced survival). The 1st RCTwas generalized to guidelines & 2nd RCT was ignored
discourse.datamethods.org/t/generaliza...
New investigation shows why critical care syndrome trials are not reproducible. This is a summary slide which shows the standardized pathology critical care syndrome RCT are not valid research
These are cause-agnostic RCT (CAR). These are the typical RCT of sepsis, ARDS, etc.
CARs always crash.
These are cause-agnostic RCT (CAR). These are the typical RCT of sepsis, ARDS, etc.
CARs always crash.
October 30, 2025 at 9:21 PM
New investigation shows why critical care syndrome trials are not reproducible. This is a summary slide which shows the standardized pathology critical care syndrome RCT are not valid research
These are cause-agnostic RCT (CAR). These are the typical RCT of sepsis, ARDS, etc.
CARs always crash.
These are cause-agnostic RCT (CAR). These are the typical RCT of sepsis, ARDS, etc.
CARs always crash.