Lawrence Lynn
@lawrencelynn.bsky.social
Pulmonary and Critical Care Research Physician.
Pinned
Lawrence Lynn
@lawrencelynn.bsky.social
· Dec 18
Flawed design and selection bias in critical care randomized controlled trials (RCTs): the patient safety risk of the "RCT mimic" - PubMed
Over three decades, randomized controlled trials (RCTs) for critical care syndromes such as acute respiratory distress syndrome (ARDS), sepsis, and community acquired pneumonia (CAP) have repeatedly produced non-reproducible results, at times leading to high-impact reversals of global protocols when …
pubmed.ncbi.nlm.nih.gov
If you are a young critical care scientist do not miss this critical care review. The landscape of critical care science is about to change. Be sure to stay ahead of the wave.
@sccmcriticalcare.bsky.social
@criticalcare.bsky.social
@criticalcarereviews.com
pubmed.ncbi.nlm.nih.gov/41402862/
@sccmcriticalcare.bsky.social
@criticalcare.bsky.social
@criticalcarereviews.com
pubmed.ncbi.nlm.nih.gov/41402862/
@intenscaremed.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:59 PM
@intenscaremed.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@doced.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:57 PM
@doced.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@esicm.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:56 PM
@esicm.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@scottishics.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:55 PM
@scottishics.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@intenscaremed.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:55 PM
@intenscaremed.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@icmexperimental.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:55 PM
@icmexperimental.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@statsmethods.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:54 PM
@statsmethods.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@berkeleyctml.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:54 PM
@berkeleyctml.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@causalscience.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:54 PM
@causalscience.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@causalab.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:53 PM
@causalab.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@causalhuber.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:53 PM
@causalhuber.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@acmedsci.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:52 PM
@acmedsci.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@medsci.ox.ac.uk
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:52 PM
@medsci.ox.ac.uk
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@clevelandclinicmls.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:52 PM
@clevelandclinicmls.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@oxfordstatistics.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:44 PM
@oxfordstatistics.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@scharr-msg.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:44 PM
@scharr-msg.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@southamptonctu.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:43 PM
@southamptonctu.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@imperialctu.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:43 PM
@imperialctu.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@primarycaretrials.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:42 PM
@primarycaretrials.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@cantrain.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:42 PM
@cantrain.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@cochrane.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:41 PM
@cochrane.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@erc.europa.eu
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:41 PM
@erc.europa.eu
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@jci.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:41 PM
@jci.org
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
@jclinepi.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
False Transport: A System-Level Patient Safety Signal of Streamlined Randomized Controlled Trials
Preprint which discloses that certain modifications of randomized controlled trial design can present a patient safety risk
doi.org
January 24, 2026 at 2:40 PM
@jclinepi.bsky.social
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...
The danger to the public of using syndromic entry criteria for RCT in critical care.
doi.org/10.5281/zeno...