🙏 Angie Galas, Nick Vaughan, Susie Feng, @zoechristensonwick.bsky.social, Paul Philipsberg, Olga Liobimova, Antonio Fernandez-Ruiz, @denisejcai.bsky.social
🙏 Angie Galas, Nick Vaughan, Susie Feng, @zoechristensonwick.bsky.social, Paul Philipsberg, Olga Liobimova, Antonio Fernandez-Ruiz, @denisejcai.bsky.social
Moving forward, we’re excited to explore if restoring theta synchrony and/or spike timing in these circuits can ameliorate memory deficits. (5/6)
Moving forward, we’re excited to explore if restoring theta synchrony and/or spike timing in these circuits can ameliorate memory deficits. (5/6)
⬇️ theta phase locking in MEC3 excitatory neurons
⬆️ firing rates in MEC2 excitatory neurons (in line with past work showing hyperexcitability in vitro)
Check out the preprint for more on other regions and celltypes! (4/6)
⬇️ theta phase locking in MEC3 excitatory neurons
⬆️ firing rates in MEC2 excitatory neurons (in line with past work showing hyperexcitability in vitro)
Check out the preprint for more on other regions and celltypes! (4/6)
In 3xTg mice, we found ⬇️ hippocampal theta power and ⬇️ theta synchrony between MEC & CA1.
These changes emerged specifically at our later timepoint, coinciding with spatial memory deficits! (3/6)
In 3xTg mice, we found ⬇️ hippocampal theta power and ⬇️ theta synchrony between MEC & CA1.
These changes emerged specifically at our later timepoint, coinciding with spatial memory deficits! (3/6)
This let us capture oscillations & single units in both hippocampus & MEC (a major source of hippocampal inputs). (2/6)
This let us capture oscillations & single units in both hippocampus & MEC (a major source of hippocampal inputs). (2/6)
for your wisdom, generosity, & support! (2/6)
for your wisdom, generosity, & support! (2/6)