www.labocine.com/events/scien...
www.labocine.com/events/scien...
Moving forward, we’re excited to explore if restoring theta synchrony and/or spike timing in these circuits can ameliorate memory deficits. (5/6)
Moving forward, we’re excited to explore if restoring theta synchrony and/or spike timing in these circuits can ameliorate memory deficits. (5/6)
⬇️ theta phase locking in MEC3 excitatory neurons
⬆️ firing rates in MEC2 excitatory neurons (in line with past work showing hyperexcitability in vitro)
Check out the preprint for more on other regions and celltypes! (4/6)
⬇️ theta phase locking in MEC3 excitatory neurons
⬆️ firing rates in MEC2 excitatory neurons (in line with past work showing hyperexcitability in vitro)
Check out the preprint for more on other regions and celltypes! (4/6)
In 3xTg mice, we found ⬇️ hippocampal theta power and ⬇️ theta synchrony between MEC & CA1.
These changes emerged specifically at our later timepoint, coinciding with spatial memory deficits! (3/6)
In 3xTg mice, we found ⬇️ hippocampal theta power and ⬇️ theta synchrony between MEC & CA1.
These changes emerged specifically at our later timepoint, coinciding with spatial memory deficits! (3/6)
This let us capture oscillations & single units in both hippocampus & MEC (a major source of hippocampal inputs). (2/6)
This let us capture oscillations & single units in both hippocampus & MEC (a major source of hippocampal inputs). (2/6)
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...
In a new preprint, we found desynchronization in medial entorhinal–hippocampal circuits that coincided with the onset of spatial memory deficits in 3xTg mice. (1/6)
www.biorxiv.org/content/10.1...