We have wondered what a complex archaeal cell might look like ever since 2014. It’s been a long road (and the journey is far from over), but it’s a good time to pause for breath and look. These Asgard archaeal cells are a surprise! And that is the joy of being a cell biologist.

We live in a tumultuous world. But I take solace in the fact that the 2010 University of Alaska Fairbanks hockey intro video remains the most unhinged thing I’ve ever seen.

Scott Campbell (character designer for Psychonauts) does this ongoing series called Great Showdowns and puts 'em up for sale. He posted this Happy Death Day one today.

I have a ton waiting for frames.

I know the term from audio encoding, where the idea is that you’re compressing files without losing information. Declaring losslessness at the *molecular* level feels like saying you could break each song on an album down to a count of notes without losing information.

Admittedly, I sequence stuff.

Destruction? What destruction? This is a lossless molecular zip algorithm working perfectly! 💥

("lossless," they say, blowing the molecules up and then cataloging the pieces with this incredibly useful technique)

Even if you don’t escape the brain damage this one is worth it.

no but no one's sneezed on it yet

v0.2's organizational defaults also make it difficult (though not impossible) for a user to accidentally push large input OR output datafiles to GitHub and have to work backwards to unfuck the situation.

As always, development is informed by personal experience. 🤦

Previously: bsky.app/profile/laur...

But more importantly for #RNAsky #RNAbiology, I don't want your finger nucleases touching the ice touching my tubes holding my RNA. pubmed.ncbi.nlm.nih.gov/13715349/

Michael, is this the right time to tell you I sometimes use my ice bucket as liquid waste disposal?

Mostly for ethanol/isopropanol washes, but still.