Laura Edgington-Mitchell
@lauraem-lab.bsky.social
Head, Protease Pathophysiology Lab at the University of Melbourne
Pinned
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Reposted by Laura Edgington-Mitchell
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Engineered reactivity of a bacterial E1-like enzyme enables ATP-driven modification of protein and peptide C termini
Nature Chemistry - In living systems, ATP provides an energetic driving force for protein synthesis and modification. Now, an engineered enzymatic tool has been developed for high-yield, ATP-driven...
rdcu.be
July 18, 2025 at 2:40 PM
Excited to share our latest: we engineered the reactivity of a bacterial E1-like enzyme for ATP-driven modification of C termini. Our tool mimics the logic of peptide bond formation in biology for precision modification of proteins in vitro. 🧪https://rdcu.be/ewN7C
Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: www.tandfonline.com/doi/full/10.... #LEMLab
Nuclear Roles for Canonically Lysosomal Proteases
While the cysteine proteases legumain and cathepsins have traditionally been known as “lysosomal” proteases, there is increasing evidence to suggest that they also contribute to a wide range of ext...
www.tandfonline.com
June 22, 2025 at 11:34 PM
Congrats to Anna and Marc for the publication of their review article "Nuclear Roles for Canonically Lysosomal Proteases.' Check it here: www.tandfonline.com/doi/full/10.... #LEMLab
Reposted by Laura Edgington-Mitchell
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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May 22, 2025 at 4:22 AM
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Reposted by Laura Edgington-Mitchell
We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!
Cutting the diagnosis journey for children born with rare genetic diseases
Families can wait years for a diagnosis of a rare genetic disorder, but a new test can provide answers in days for a better understanding of the condition and potentially earlier treatment, finds new...
pursuit.unimelb.edu.au
May 23, 2025 at 12:57 AM
We're super proud to see our study showing utility of proteomics in ultra-rapid variant prioritisation for suspected mito and other rare diseases out in Genome Medicine (rdcu.be/endwE). Too many amazing collabs to thank, so here are the big ones @daniellahock.bsky.social @thorburnmito.bsky.social!
Reposted by Laura Edgington-Mitchell
The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn).
www.vergentbio.com/press-releas...
www.vergentbio.com/press-releas...
Vergent Bioscience Presents Phase 2B VISUALIZE Results Demonstrating Abenacianine for Injection (VGT-309) with Intraoperative Molecular Imaging Improved Tumor Visualization During Lung Surgery | Verge...
www.vergentbio.com
May 22, 2025 at 9:36 PM
The phase IIb results from the multi center trail of our cathepsin probe (VGT-309/abenacianine) are out. The probe met its endpoints and resulted in significant clinical events in 45% of patients. Great work by Vergent Biosciences and Dr. Sunil Singhal (UPenn).
www.vergentbio.com/press-releas...
www.vergentbio.com/press-releas...
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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May 22, 2025 at 4:22 AM
The 13th General Meeting of the International Proteolysis Society will be held in Búsios, Brazil Oct 26-30, 2025. Training workshops will be held at the Instituto Oswaldo Cruz Oct 23-23. Register now! Links below.
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Reposted by Laura Edgington-Mitchell
We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner.
A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)
A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
April 25, 2025 at 12:14 AM
We also show that Coxiella incites the extracellular secretion of lysosomal content in a T4SS independent manner.
A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)
A wonderfully enjoyable collaboration with @lauraem-lab.bsky.social & @hayleyjnewton.bsky.social labs (with significant mass spec guidance from @nickescott.bsky.social!)
Reposted by Laura Edgington-Mitchell
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success - Nature Communications
The zoonotic pathogen Coxiella burnetiiestablishes a unique intracellular niche within a lysosome-derived vacuole. Here Bird et al. undertook proteomic, cell biology and microbiology approaches to cha...
www.nature.com
April 25, 2025 at 12:14 AM
Excited to share this story from my PhD, out today in Nature Communications! We show that Coxiella removes cathepsin B to reduce lysosomal hostility and promote bacterial success. This depends on a vacuole established by effector CvpB.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Laura Edgington-Mitchell
Great visit to Melbourne Uni to give a talk and visit with my former PhD student Laura Edgington-Mitchell and her lab.
April 12, 2025 at 4:26 AM
Great visit to Melbourne Uni to give a talk and visit with my former PhD student Laura Edgington-Mitchell and her lab.
Reposted by Laura Edgington-Mitchell
The ARC Board has proposed a major shake-up of the National Competitive Grants Program ▶️ www.arc.gov.au/engage-us/co...
I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇
Submissions are being accepted in response until 13 April. Get to it!
I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇
Submissions are being accepted in response until 13 April. Get to it!
February 25, 2025 at 3:46 AM
The ARC Board has proposed a major shake-up of the National Competitive Grants Program ▶️ www.arc.gov.au/engage-us/co...
I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇
Submissions are being accepted in response until 13 April. Get to it!
I've only skimmed so far, but they propose reducing 13 grant schemes to 6, with intent & scope in the table👇
Submissions are being accepted in response until 13 April. Get to it!