M-A Langlois
@langlois-ma.bsky.social
🇨🇦Professor of Medicine at uOttawa| Molecular virologist | Studies host immune responses to respiratory viruses 🦠 and retroviruses | Involved in pandemic preparedness research 🔬 | High throughput serology and molecular diagnostics of pathogens 🧪
Reposted by M-A Langlois
It is difficult, if not impossible, to think of a biomedical scientist whose many diverse discoveries had more impact than those of David Baltimore.
www.latimes.com/obituaries/s...
www.latimes.com/obituaries/s...
David Baltimore, Nobel Prize-winning scientist and former Caltech president, dies at 87
Baltimore played a role in virtually every important national debate over the use and potential misuse of the science of genetic engineering.
www.latimes.com
September 8, 2025 at 5:41 AM
It is difficult, if not impossible, to think of a biomedical scientist whose many diverse discoveries had more impact than those of David Baltimore.
www.latimes.com/obituaries/s...
www.latimes.com/obituaries/s...
Reposted by M-A Langlois
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins encoded by endogenous retroviruses are required for zebrafish development | PNAS
Transposable elements (TEs) make up the bulk of eukaryotic genomes and examples abound
of TE-derived sequences repurposed for organismal function. ...
www.pnas.org
April 30, 2025 at 10:45 AM
💥🥳 At long last, our latest paper is out!
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Gag proteins of endogenous retroviruses are required for zebrafish development
www.pnas.org/doi/10.1073/...
Led heroically by Sylvia Chang & @jonowells.bsky.social
A study which has changed the way I think of #transposons! No less! 🧵 1/n
Reposted by M-A Langlois
So this interview lasted 2 hours so this “you’re scaring me” part might seem like an overreaction or fearmongering to someone without that context.
There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.
There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.
April 21, 2025 at 1:28 PM
So this interview lasted 2 hours so this “you’re scaring me” part might seem like an overreaction or fearmongering to someone without that context.
There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.
There’s a lot of evidence to support my hypothesis that a potential H5N1 pandemic would be worse than COVID.
Reposted by M-A Langlois
We were just notified that our contract to UCSD and Scripps Research to support wastewater surveillance in San Diego (searchcovid.info) was terminated immediately for the same reasons 👇.
That means no more genomic wastewater surveillance, and our proposed extensions to measles, Hep A, others, gone.
That means no more genomic wastewater surveillance, and our proposed extensions to measles, Hep A, others, gone.
April 7, 2025 at 4:29 PM
We were just notified that our contract to UCSD and Scripps Research to support wastewater surveillance in San Diego (searchcovid.info) was terminated immediately for the same reasons 👇.
That means no more genomic wastewater surveillance, and our proposed extensions to measles, Hep A, others, gone.
That means no more genomic wastewater surveillance, and our proposed extensions to measles, Hep A, others, gone.
Reposted by M-A Langlois
Perhaps an executive order banning future pandemics?
Dark Age 2.0
NIH to cut grants for COVID research, documents reveal www.nature.com/articles/d41... via @nature.com
"If we don’t figure this out now with this pandemic, I’m afraid we will be much less prepared for future pandemics."
Dark Age 2.0
NIH to cut grants for COVID research, documents reveal www.nature.com/articles/d41... via @nature.com
"If we don’t figure this out now with this pandemic, I’m afraid we will be much less prepared for future pandemics."
Exclusive: NIH to cut grants for COVID research, documents reveal
Studies on climate change and South Africa are also on the latest list of grants to be terminated, according to updated documents obtained by Nature.
www.nature.com
March 26, 2025 at 11:09 PM
Perhaps an executive order banning future pandemics?
Dark Age 2.0
NIH to cut grants for COVID research, documents reveal www.nature.com/articles/d41... via @nature.com
"If we don’t figure this out now with this pandemic, I’m afraid we will be much less prepared for future pandemics."
Dark Age 2.0
NIH to cut grants for COVID research, documents reveal www.nature.com/articles/d41... via @nature.com
"If we don’t figure this out now with this pandemic, I’m afraid we will be much less prepared for future pandemics."
Reposted by M-A Langlois
After 5 years, 150k papers and 17 million genomes, here's what we learned about SARS-CoV-2 and viruses in general.
It holds lessons for future pandemics - only if we listen. "We’re in a worse place in terms of pandemic prevention" @eddieholmes.bsky.social told me.
www.nature.com/articles/d41...
It holds lessons for future pandemics - only if we listen. "We’re in a worse place in terms of pandemic prevention" @eddieholmes.bsky.social told me.
www.nature.com/articles/d41...
Four ways COVID changed virology: lessons from the most sequenced virus of all time
After 150,000 articles and 17 million genome sequences, what has science taught us about SARS-CoV-2?
www.nature.com
March 13, 2025 at 10:24 AM
After 5 years, 150k papers and 17 million genomes, here's what we learned about SARS-CoV-2 and viruses in general.
It holds lessons for future pandemics - only if we listen. "We’re in a worse place in terms of pandemic prevention" @eddieholmes.bsky.social told me.
www.nature.com/articles/d41...
It holds lessons for future pandemics - only if we listen. "We’re in a worse place in terms of pandemic prevention" @eddieholmes.bsky.social told me.
www.nature.com/articles/d41...
Reposted by M-A Langlois
Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune history shapes human antibody responses to H5N1 influenza viruses - Nature Medicine
H5N1 strain-specific antibodies are higher in older individuals and correlate more with birth year than with age, suggesting that younger individuals are potentially more likely to benefit from H5N1 v...
www.nature.com
March 13, 2025 at 5:39 PM
Today @natmedicine.bsky.social published our study showing the older individuals born prior to 1968 have more antibodies that cross-react to #H5N1 relative to younger individuals. If H5N1 causes a pandemic, children will likely be the most susceptible. 1/2
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by M-A Langlois
Of the 4000 researchers at NIH, only 20% are tenured. They’re going to fire all the rest as their contracts come up for renewal, absolutely decimating research at the NIH. This is catastrophic, not just for Americans, but for the whole world.
www.science.org/content/arti...
www.science.org/content/arti...
NIH ban on renewing senior scientists adds to assaults on its in-house research
Policy follows firings of tenure-track scientists and suspension of training programs
www.science.org
February 28, 2025 at 6:19 AM
Of the 4000 researchers at NIH, only 20% are tenured. They’re going to fire all the rest as their contracts come up for renewal, absolutely decimating research at the NIH. This is catastrophic, not just for Americans, but for the whole world.
www.science.org/content/arti...
www.science.org/content/arti...
Reposted by M-A Langlois
#COVID19 remains a reality, despite not making headlines. So, do you still need a #COVID vaccine? Does the type of vaccine matter? Should you get the flu & COVID-19 vaccines together?
Our experts break it down: covarrnet.ca/the-pros-and...
Our experts break it down: covarrnet.ca/the-pros-and...
December 18, 2024 at 4:07 PM
#COVID19 remains a reality, despite not making headlines. So, do you still need a #COVID vaccine? Does the type of vaccine matter? Should you get the flu & COVID-19 vaccines together?
Our experts break it down: covarrnet.ca/the-pros-and...
Our experts break it down: covarrnet.ca/the-pros-and...
Reposted by M-A Langlois
The latest edition of The CoVaRR-Net Quarterly newsletter is out.
Should you still get vaccinated against COVID-19? Learn more about how CoVaRR-Net members are pivoting to Bird Flu research. Plus, we spotlight eight exceptional HQPs from our network.
Read and subscribe: mailchi.mp/1cd351797d31...
Should you still get vaccinated against COVID-19? Learn more about how CoVaRR-Net members are pivoting to Bird Flu research. Plus, we spotlight eight exceptional HQPs from our network.
Read and subscribe: mailchi.mp/1cd351797d31...
December 13, 2024 at 5:37 PM
The latest edition of The CoVaRR-Net Quarterly newsletter is out.
Should you still get vaccinated against COVID-19? Learn more about how CoVaRR-Net members are pivoting to Bird Flu research. Plus, we spotlight eight exceptional HQPs from our network.
Read and subscribe: mailchi.mp/1cd351797d31...
Should you still get vaccinated against COVID-19? Learn more about how CoVaRR-Net members are pivoting to Bird Flu research. Plus, we spotlight eight exceptional HQPs from our network.
Read and subscribe: mailchi.mp/1cd351797d31...
Reposted by M-A Langlois
Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
December 12, 2024 at 7:02 PM
Science’s 2024 Breakthrough of the Year is lenacapavir, an injectable drug that demonstrated remarkable success at preventing HIV infection with one shot every 6 months.
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
Learn more about this year's #BOTY and other big advances in science: scim.ag/3BrCtUn
Reposted by M-A Langlois
Interesting follow-up on this. We're running automated analyses on H5N1 data on the SRA to look for potentially important mutations in the virus.
Following the study 👇, we looked to see if we could find *any* evidence of the HA Q226L mutation.
We did. In a mouse from June of this year.
Short 🧵
Following the study 👇, we looked to see if we could find *any* evidence of the HA Q226L mutation.
We did. In a mouse from June of this year.
Short 🧵
If an #H5N1 pandemic starts tomorrow or in three months, there will be little mystery as to how it happened. The conditions are all there. They have been for a while.
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
So in some ways the more interesting question to me at the moment is: Why aren’t we in a pandemic yet?
Story here, 🧵 to come:
🧪#IDSky
Why hasn’t the bird flu pandemic started?
Some scientists examining mutations found in H5N1 viruses fear major outbreak is imminent but others says pathogen remains unpredictable
www.science.org
December 6, 2024 at 8:02 PM
Interesting follow-up on this. We're running automated analyses on H5N1 data on the SRA to look for potentially important mutations in the virus.
Following the study 👇, we looked to see if we could find *any* evidence of the HA Q226L mutation.
We did. In a mouse from June of this year.
Short 🧵
Following the study 👇, we looked to see if we could find *any* evidence of the HA Q226L mutation.
We did. In a mouse from June of this year.
Short 🧵