Denis LJ Lafontaine
@lafontainelab.bsky.social
RNA Biologist
Ribosome biogenesis dysfunction diseases
Structure-Function relationships in the Nucleolus
Biomolecular condensates
www.lafontainelab.com
Ribosome biogenesis dysfunction diseases
Structure-Function relationships in the Nucleolus
Biomolecular condensates
www.lafontainelab.com
Reposted by Denis LJ Lafontaine
Reposted by Denis LJ Lafontaine
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis
Distinguishing self from non-self is crucial to direct immune responses against pathogens. Unmodified RNAs stimulate human innate immunity, but RNA modifications suppress this response. mRNA m6A modif...
www.biorxiv.org
February 24, 2025 at 12:05 PM
New preprint from us!
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
We find that disruption of the mRNA m6A writer complex triggers autoimmunity in Arabidopsis –
www.biorxiv.org/content/10.1...
Reposted by Denis LJ Lafontaine
Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!
www.tandfonline.com/journals/krn...
www.tandfonline.com/journals/krn...
TRANSLACORE, a European network to coordinate research on translation regulation in cancer
Explore the article collection: TRANSLACORE, a European network to coordinate research on translation regulation in cancer. Published in RNA Biology.
www.tandfonline.com
July 17, 2025 at 1:07 PM
Very happy to see our work, "The implication of non-AUG-initiated N-terminally extended proteoforms in cancer," in this special collection of RNA Biology! 💫 Thanks to @lafontainelab.bsky.social and TRANSLACORE for the opportunity to contribute to this collection!
www.tandfonline.com/journals/krn...
www.tandfonline.com/journals/krn...
July 2, 2025 at 6:51 AM
Reposted by Denis LJ Lafontaine
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
A postdoc position in the Torben Heick Jensen lab, Aarhus University, Denmark: Mammalian Nuclear RNA Production and Turnover Systems - Vacancy at Aarhus University
Vacancy at Department of Molecular Biology and Genetics - RNA Biology and Innovation, Aarhus University
mbg.au.dk
June 27, 2025 at 6:03 AM
Postdoc positions available in the Heick Jensen lab in sunny Aarhus. Sorting of good and bad RNAs in mammalian nuclei. Please get in touch for further information and/or use the following link to apply:
mbg.au.dk/en/news-and-...
mbg.au.dk/en/news-and-...
Reposted by Denis LJ Lafontaine
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Transfer RNA acetylation regulates in vivo mammalian stress signaling
An ancient tRNA modification is used by mammalian cells to coordinate protein translation and adaptive signaling.
www.science.org
March 20, 2025 at 1:42 AM
Excited to share this one! We developed an in vivo model for specific manipulation of transfer RNA acetylation and found it serves as a sentinel modification whose loss causes ribosome stalling and stress signaling. Implications for a genetic disorder and cancer.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Reposted by Denis LJ Lafontaine
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
March 18, 2025 at 6:50 PM
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
Reposted by Denis LJ Lafontaine
come join!
Message to my 11 followers in Bluesky:
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
We are pleased to announce that registrations for the International EMBO workshop Ribosome Synthesis: from Mechanisms to Therapy 13th Edition are now open!
Details and registration: www.eventsforce.net/hg3/frontend...
The Organizing Committee
March 19, 2025 at 5:17 PM
come join!
Reposted by Denis LJ Lafontaine
How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...
authors.elsevier.com/a/1kS2f3vVUP...
January 20, 2025 at 4:07 PM
How has native RNA sequencing contributed to epitranscriptomic research? This is one of the main questions we addressed in our recent review by @evamarianovoa.bsky.social and I now live in Molecular Cell #RNAsky #RNA #nanopore
authors.elsevier.com/a/1kS2f3vVUP...
authors.elsevier.com/a/1kS2f3vVUP...
Reposted by Denis LJ Lafontaine
Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.
Ribosome Fingerprints: A Breakthrough in Early Cancer Detection
Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.
www.science-tldr.com
December 10, 2024 at 7:09 PM
Discover how unique ribosome fingerprints could revolutionize early cancer detection with non-invasive, portable scanners able to detect cancer with near-perfect accuracy.
Reposted by Denis LJ Lafontaine
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
November 28, 2024 at 10:31 AM
And since we're here... 🥼
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Join us as a Group Leader in #ComputationalBiology or #RNA Biology 🧬
More details via www.imb.de/jobs
Application deadline is 5 January 2025
#sciencejobs #resilience #biostatistics
Reposted by Denis LJ Lafontaine
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
November 19, 2024 at 2:55 AM
Check it out! The RNA Society 2025 Meeting Site is now live! Registration will open in January RNASociety Note the fabulous artwork by former EmoryBCDB student Dr. Carly Lancaster- make your plans now to join us in San Diego May 27-June 1, 2025
Reposted by Denis LJ Lafontaine
Published online today @jcellbiol.bsky.social you will find our latest work on Cajal bodies. 😅🎉 It has been a joy to work with Chuyue Zhang, Dahyana Arias Escayola, and colleagues! doi.org/10.1083/jcb....
#RNAsky #RNAbiology
#RNAsky #RNAbiology
Identification of coilin interactors reveals coordinated control of Cajal body number and structure
This study identifies new Cajal body components and tests their roles in the formation of these nuclear membraneless organelles. Imbalances in the levels o
doi.org
November 27, 2024 at 6:48 PM
Published online today @jcellbiol.bsky.social you will find our latest work on Cajal bodies. 😅🎉 It has been a joy to work with Chuyue Zhang, Dahyana Arias Escayola, and colleagues! doi.org/10.1083/jcb....
#RNAsky #RNAbiology
#RNAsky #RNAbiology
Reposted by Denis LJ Lafontaine
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis
An RNA′s catalytic, regulatory, or coding potential depends on RNA structure formation. Because base pairing occurs during transcription, early structural states can govern RNA processing events and d...
www.biorxiv.org
November 27, 2024 at 1:38 PM
We are happy to share the development of Co-transcriptional Structure Tracking by @leoschaerfen.bsky.social, which measures RNA structure formation during its synthesis in vivo. We are excited to discover the activity of helicases on nascent rRNA!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
November 27, 2024 at 11:25 AM
Happy to share the website of RiboMod2025, the "Conference on Ribosomal RNA modifications and snoRNAs" in Bologna June 12-13, 2025 is up at events.unibo.it/ribomod2025
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Stay tune for more infos!
#RNA #Ribosome #snoRNA #Eiptranscriptomics
Reposted by Denis LJ Lafontaine
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
November 24, 2024 at 6:16 PM
Hot off the press: new review @AnnualReviews discusses recent time-resolved cryo-EM studies visualizing how ribosome moves and interacts with translation factors to achieve efficient and accurate translation.
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
“The Structural Dynamics of Translation”: https://tinyurl.com/2ezt9st9
Reposted by Denis LJ Lafontaine
Are you a PhD student or postdoc working in Belgium and on a #cellbio or #devbio or #evodevo topic, consider applying for a travel grant to support travel to the next conference you want to attend! Check out details on our website www.bscdb.be/membership-g...
Membership & Grants | Belgian Society for Cell and Developmental Biology
www.bscdb.be
November 20, 2024 at 8:56 PM
Are you a PhD student or postdoc working in Belgium and on a #cellbio or #devbio or #evodevo topic, consider applying for a travel grant to support travel to the next conference you want to attend! Check out details on our website www.bscdb.be/membership-g...