Xavier Charpentier
@labxc.bsky.social
Group leader.
HGT in bacterial pathogens. Acinetobacter, Legionella. Natural transformation. AMR. MGEs.
Centre International de Recherche en Infectiologie
HGT in bacterial pathogens. Acinetobacter, Legionella. Natural transformation. AMR. MGEs.
Centre International de Recherche en Infectiologie
What wonderful news! Congratulations, François, this is well-deserved recognition of your talent. I can't wait to see what you and your team will discover.
September 4, 2025 at 2:02 PM
What wonderful news! Congratulations, François, this is well-deserved recognition of your talent. I can't wait to see what you and your team will discover.
Frankly, I don't know how robust the data supported the probiotic role of Nissle 1917, but there is such large body of work on the genotoxic nature of colibactin and Nissle 1917 that I don't understand why Mutaflor has not yet been banned. Tagging @jpnoug.bsky.social
February 13, 2025 at 2:51 PM
Frankly, I don't know how robust the data supported the probiotic role of Nissle 1917, but there is such large body of work on the genotoxic nature of colibactin and Nissle 1917 that I don't understand why Mutaflor has not yet been banned. Tagging @jpnoug.bsky.social
That's an unfortunate naming. I believe that the name preceded the identification of colibactin.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Escherichia coli Induces DNA Double-Strand Breaks in Eukaryotic Cells
Transient infection of eukaryotic cells with commensal and extraintestinal pathogenic Escherichia coli of phylogenetic group B2 blocks mitosis and induces megalocytosis. This trait is linked to a wide...
www.science.org
February 13, 2025 at 2:51 PM
That's an unfortunate naming. I believe that the name preceded the identification of colibactin.
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer
bsky.app/profile/them...
bsky.app/profile/them...
New paper:
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
We show that population exposure to colibactin producing E. coli lineages ST95 and ST73 largely explains global variation in colorectal cancer incidence. Same STs are also major causes of UTIs and may be similarly involved in urinary tract cancers.
www.sciencedirect.com/science/arti...
Geographical variation in the incidence of colorectal cancer and urinary tract cancer is associated with population exposure to colibactin-producing Escherichia coli
Biomedical research has implicated the bacterial metabolite colibactin as a causal risk factor for several cancer types, in particular, colorectal can…
www.sciencedirect.com
February 13, 2025 at 2:29 PM
The most worrisome is that this strain is a well know producer of the colibactin genotoxin, which may be associated with colorectal cancer
bsky.app/profile/them...
bsky.app/profile/them...
Reposted by Xavier Charpentier
Our study on the (huge) variations in transformation rates is now out in OA! Key question: why are so many strains non-transformable if the many recent transitions to non-transformability seem deleterious? doi.org/10.1371/jour...
Intragenomic conflicts with plasmids and chromosomal mobile genetic elements drive the evolution of natural transformation within species
Bacterial species exhibit large variations in their transformation rates. This study of Legionella pneumophila and Acinetobacter baumannii shows that their transformation rates evolve by sudden quick ...
doi.org
October 15, 2024 at 4:25 PM
Our study on the (huge) variations in transformation rates is now out in OA! Key question: why are so many strains non-transformable if the many recent transitions to non-transformability seem deleterious? doi.org/10.1371/jour...