Furukawa Lab @CSHL
@lab-furukawa.bsky.social
Structural neurobiology lab @Cold Spring Harbor Laboratory. Cryo-EM, X-ray crystallography, Electrophysiology, Membrane protein biochemistry, Molecular neuroscience, Neuroimmunology. https://furukawalab.labsites.cshl.edu/
Pinned
--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...
Reposted by Furukawa Lab @CSHL
Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...
nature.com/articles/s41...
November 21, 2025 at 6:42 PM
Our latest work : Statins are used to lower plasma cholesterol but often come with muscle-related side effects. Using cryo-EM, we show how multiple statin molecules cooperate to bind RyR1, a calcium release channel mainly found in skeletal muscle.
nature.com/articles/s41...
nature.com/articles/s41...
Reposted by Furukawa Lab @CSHL
Re-upping this - Neuropeeps! We have a TT Job in my wonderful department at Brandeis! First consideration to applications received by Dec 15 (but why wait?)
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Assistant Professor in Biology and Neuroscience Program - Waltham, Massachusetts (US) job with Brandeis University | 12848464
The Department of Biology and the Program in Neuroscience at Brandeis University invite applications for a tenure-track Assistant Professor positio...
www.nature.com
November 20, 2025 at 3:03 PM
Re-upping this - Neuropeeps! We have a TT Job in my wonderful department at Brandeis! First consideration to applications received by Dec 15 (but why wait?)
www.nature.com/naturecareer...
www.nature.com/naturecareer...
Reposted by Furukawa Lab @CSHL
Now in the journal issue! Molecular mechanism of activation of kainate receptor GluK2 in complex with auxiliary subunit Neto2.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 18, 2025 at 5:59 PM
Now in the journal issue! Molecular mechanism of activation of kainate receptor GluK2 in complex with auxiliary subunit Neto2.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Furukawa Lab @CSHL
We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...
--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
October 6, 2025 at 8:42 PM
We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...
Reposted by Furukawa Lab @CSHL
Calcium and magnesium in the pore of NMDA receptors!
Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.
Very stimulating work! Congrats @lab-furukawa.bsky.social
#iglurs
Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.
Very stimulating work! Congrats @lab-furukawa.bsky.social
#iglurs
November 8, 2025 at 6:30 AM
Calcium and magnesium in the pore of NMDA receptors!
Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.
Very stimulating work! Congrats @lab-furukawa.bsky.social
#iglurs
Lipids play an unexpected role. The hydration shells of Ca2+ and Mg2+ could be the difference between permeation and block. So much physiology in the energetics of H2O.
Very stimulating work! Congrats @lab-furukawa.bsky.social
#iglurs
Reposted by Furukawa Lab @CSHL
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome
Angelman syndrome (AS) is a neurogenetic disorder characterized by motor coordination and cognitive deficits. In AS, hippocampal neurons show reduced filamentous (F-)actin, a decrease we also reported...
www.jneurosci.org
November 6, 2025 at 8:03 PM
Our new Journal of Neuroscience paper "Cofilin Inhibition Ameliorates PIEZO2 and AMPA Dysfunction in a Mouse Model of Angelman Syndrome (AS)” is out: www.jneurosci.org/content/45/4... 1/6
Reposted by Furukawa Lab @CSHL
Magnesium site in TRPV6 is formed by two negatively charged residues that are close together in the closed state and separated in the open. Magnesium binding keeps them together and stabilizes the closed state. Amazing collaboration with Chubanov and Efremov groups. www.nature.com/articles/s41...
November 6, 2025 at 5:49 PM
Magnesium site in TRPV6 is formed by two negatively charged residues that are close together in the closed state and separated in the open. Magnesium binding keeps them together and stabilizes the closed state. Amazing collaboration with Chubanov and Efremov groups. www.nature.com/articles/s41...
Reposted by Furukawa Lab @CSHL
My department, Cornell BME, is hiring!
This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship.
📝 academicjobsonline.org/ajo/jobs/30816
This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship.
📝 academicjobsonline.org/ajo/jobs/30816
October 28, 2025 at 6:31 PM
My department, Cornell BME, is hiring!
This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship.
📝 academicjobsonline.org/ajo/jobs/30816
This tenure-track faculty position is a great opportunity to join a vibrant community that values research, teaching, and entrepreneurship.
📝 academicjobsonline.org/ajo/jobs/30816
Reposted by Furukawa Lab @CSHL
A new study from the Furukawa lab (@lab-furukawa.bsky.social) identifies the neurological ‘doorstops’ that keep the brain’s NMDA receptors fully or partially open. The findings could have implications for treating neurodegenerative conditions like #Alzheimers disease. www.cshl.edu/a-doorstop-f...
A doorstop for the brain’s electrical gates | Cold Spring Harbor Laboratory
As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores ...
www.cshl.edu
October 29, 2025 at 6:37 PM
A new study from the Furukawa lab (@lab-furukawa.bsky.social) identifies the neurological ‘doorstops’ that keep the brain’s NMDA receptors fully or partially open. The findings could have implications for treating neurodegenerative conditions like #Alzheimers disease. www.cshl.edu/a-doorstop-f...
How are NMDA receptor channel conductance states regulated? We uncover a mechanism for tuning ion flow and reveal striking diversity in neurosteroid binding. Our structures captured two distinct open-channel states. A fantastic collaboration with the Traynelis lab.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanism of conductance control and neurosteroid binding in NMDA receptors - Nature
Ion-channel conductance levels are controlled by the bending patterns of pore-forming transmembrane helices in the heterotetrameric neuronal channel GluN1a-2B N-methyl-D-aspartate receptor.
www.nature.com
October 29, 2025 at 4:12 PM
How are NMDA receptor channel conductance states regulated? We uncover a mechanism for tuning ion flow and reveal striking diversity in neurosteroid binding. Our structures captured two distinct open-channel states. A fantastic collaboration with the Traynelis lab.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Furukawa Lab @CSHL
Apply to the new CSHL grad program in BioAI/neuroAI!
(Masters degree or equivalent required in a quantitative area such as computer science, physics, mathematics, or engineering)
www.cshl.edu/phd-program/...
(Masters degree or equivalent required in a quantitative area such as computer science, physics, mathematics, or engineering)
www.cshl.edu/phd-program/...
October 22, 2025 at 11:59 PM
Apply to the new CSHL grad program in BioAI/neuroAI!
(Masters degree or equivalent required in a quantitative area such as computer science, physics, mathematics, or engineering)
www.cshl.edu/phd-program/...
(Masters degree or equivalent required in a quantitative area such as computer science, physics, mathematics, or engineering)
www.cshl.edu/phd-program/...
Reposted by Furukawa Lab @CSHL
Our home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! recruit.ap.uci.edu/JPF09887
Please apply and/or share this post.
Please apply and/or share this post.
Assistant Professor in Structural Biology and Biochemistry, Department of Molecular Biology & Biochemistry
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
October 17, 2025 at 11:23 PM
Our home department of Molecular Biology & Biochemistry at UC Irvine is looking to hire a new tenure-track assistant professor in the broad area of structural biology. Come be our colleague! recruit.ap.uci.edu/JPF09887
Please apply and/or share this post.
Please apply and/or share this post.
Reposted by Furukawa Lab @CSHL
UGA is seeking a tenure-track Assistant Professor to develop an innovative research program focused on disease mechanisms. The ideal candidate will use cryo-EM and other structural techniques, with potential applications to future therapies.
Apply here: www.ugajobsearch.com/postings/456...
Apply here: www.ugajobsearch.com/postings/456...
Assistant Professor of Structural Biology
The Franklin College of Arts and Sciences at the University of Georgia (UGA) invites applications for multiple open faculty positions, beginning August 1, 2026. We are broadly interested in scientists...
www.ugajobsearch.com
October 22, 2025 at 3:35 PM
UGA is seeking a tenure-track Assistant Professor to develop an innovative research program focused on disease mechanisms. The ideal candidate will use cryo-EM and other structural techniques, with potential applications to future therapies.
Apply here: www.ugajobsearch.com/postings/456...
Apply here: www.ugajobsearch.com/postings/456...
Reposted by Furukawa Lab @CSHL
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
October 21, 2025 at 9:47 PM
The Department of Biochemistry and Molecular Biology at UTHealth Houston has an open search for a tenure-track faculty position. If you are ready (or know someone that is) to start looking for positions, this will be a great opportunity to join the Texas Medical Center. See flyer below. 1/2
Reposted by Furukawa Lab @CSHL
PhD project alert: the excellent MIBTP programme is open for applications. I am offering an exciting project on endogenous membrane protein complexes, jointly supervised with @alangoddard.bsky.social. Please spread the word!
warwick.ac.uk/fac/cross_fa...
warwick.ac.uk/fac/cross_fa...
Dr Naomi Pollock
Dr Naomi Pollock
warwick.ac.uk
October 15, 2025 at 8:21 AM
PhD project alert: the excellent MIBTP programme is open for applications. I am offering an exciting project on endogenous membrane protein complexes, jointly supervised with @alangoddard.bsky.social. Please spread the word!
warwick.ac.uk/fac/cross_fa...
warwick.ac.uk/fac/cross_fa...
Reposted by Furukawa Lab @CSHL
The Rutgers Brain Health Institute @rutgersbhi.bsky.social is looking for an accomplished scientist to serve as the Director of the new Rutgers Center on Research in Pain and Pain Therapeutics. Feel free re-post and/or reach out to me if you have any questions
jobs.rutgers.edu/postings/225...
jobs.rutgers.edu/postings/225...
Director of Center on Research in Pain and Pain Therapeutics at Rutgers Brain Health Institute
We seek an accomplished scientist, at the Professor or Associate Professor level, to join the Rutgers Brain Health Institute (BHI) and The Rutgers School of Dental Medicine (RSDM) as Director of the n...
jobs.rutgers.edu
October 8, 2025 at 3:22 PM
The Rutgers Brain Health Institute @rutgersbhi.bsky.social is looking for an accomplished scientist to serve as the Director of the new Rutgers Center on Research in Pain and Pain Therapeutics. Feel free re-post and/or reach out to me if you have any questions
jobs.rutgers.edu/postings/225...
jobs.rutgers.edu/postings/225...
We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...
--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
October 6, 2025 at 8:42 PM
We have postdoctoral positions available for patch-clampers and structural biologists #cryo-EM #electrophysiology #cancer-neuroimmunology #neuropharmacology jobrxiv.org/job/cold-spr...
academic.oup.com/brain/advanc... with Hongjie Yuan and Steve Traynelis. We went back to x-ray crystallography to capture radiprodil, a classic psychiatric compound.
Inhibition of GluN2B-containing N-methyl-d-aspartate receptors by radiprodil
Banke et al. identified the structural determinants of radiprodil binding and the mechanism by which it inhibits GluN2B-NMDARs. They found that radiprodil
academic.oup.com
September 30, 2025 at 3:21 PM
academic.oup.com/brain/advanc... with Hongjie Yuan and Steve Traynelis. We went back to x-ray crystallography to capture radiprodil, a classic psychiatric compound.
Reposted by Furukawa Lab @CSHL
Our paper on 'mini analysis' is now published in @jphysiol.bsky.social
If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..!
Happy to discuss if you are interested
physoc.onlinelibrary.wiley.com/doi/10.1113/...
If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..!
Happy to discuss if you are interested
physoc.onlinelibrary.wiley.com/doi/10.1113/...
‘Mini analysis’ misrepresents changes in synaptic properties due to incomplete event detection
Abstract figure legend Summary of the study where simulated recordings (left) were used to characterise the effect of incomplete detection on mini (mPSC) analysis. Recording noise levels (red) determ...
physoc.onlinelibrary.wiley.com
September 29, 2025 at 11:54 AM
Our paper on 'mini analysis' is now published in @jphysiol.bsky.social
If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..!
Happy to discuss if you are interested
physoc.onlinelibrary.wiley.com/doi/10.1113/...
If you are recording mPSCs or sPSCs, I hope this helps with analysis. Interpretation of these datasets is not as easy as it seems..!
Happy to discuss if you are interested
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Reposted by Furukawa Lab @CSHL
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements
Opening of the NMDA receptor involves bending of the helices lining the ion channel gate.
www.science.org
September 24, 2025 at 6:39 PM
Cryo-EM snapshots of NMDA receptor activation illuminate sequential rearrangements | Science Advances www.science.org/doi/10.1126/...
Reposted by Furukawa Lab @CSHL
🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
September 17, 2025 at 5:07 PM
🚀 Check out our new preprint on extending the scope of single-particle cryo-EM with 2D template matching!
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching is now available on bioRxiv!
www.biorxiv.org/content/10.1...
Reposted by Furukawa Lab @CSHL
After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 17, 2025 at 3:30 PM
After years in making, I am glad to be able to share our attempt on establishing a framework for combined functional and computational assessment of variant pathogenicity in the sodium leak channel NALCN:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Furukawa Lab @CSHL
🚨🧠🔬 A major breakthrough in molecular neuroscience:
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
September 16, 2025 at 4:47 PM
🚨🧠🔬 A major breakthrough in molecular neuroscience:
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
I am excited to share a new story from our lab, published in accelerated format today by @nature.com:
"Delta-type glutamate receptors are ligand-gated ion channels"
Read more here (free article link): rdcu.be/eGIKz
We have two postdoctoral fellow positions—one for a structural biologist and another for an electrophysiologist. We have new, exciting projects related to neurobiology, neuro-cancer-immunology, and neuropharmacology. #electrophysiology #cryo-EM #neuro-xyz
jobrxiv.org/job/cold-spr...
We have a postdoctoral fellow position available. Please visit our lab website (furukawalab.labsites.cshl.edu), learn about us, and apply if you're interested in our science!
We have a postdoctoral fellow position available. Please visit our lab website (furukawalab.labsites.cshl.edu), learn about us, and apply if you're interested in our science!
--Postdoctoral Fellowship in Structural Neurophysiology at CSHL—
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobrxiv.org
September 4, 2025 at 3:33 PM
We have two postdoctoral fellow positions—one for a structural biologist and another for an electrophysiologist. We have new, exciting projects related to neurobiology, neuro-cancer-immunology, and neuropharmacology. #electrophysiology #cryo-EM #neuro-xyz
Reposted by Furukawa Lab @CSHL
Kainate receptor modulation by Neto including an open state. Surprising, to me: I would never have imagined that Neto works like a membrane-tethered lectin (ConA). Auxiliary proteins influence dimer-dimer interactions, as we and others also showed in AMPARs.
#iGluRs
www.nature.com/articles/s41...
#iGluRs
www.nature.com/articles/s41...
Activation of kainate receptor GluK2–Neto2 complex - Nature Structural & Molecular Biology
Gangwar et al. present cryo-electron microscopy structures of GluK2 kainate receptors with auxiliary subunit Neto2 and reveal the basis of receptor activation.
www.nature.com
August 26, 2025 at 7:17 AM
Kainate receptor modulation by Neto including an open state. Surprising, to me: I would never have imagined that Neto works like a membrane-tethered lectin (ConA). Auxiliary proteins influence dimer-dimer interactions, as we and others also showed in AMPARs.
#iGluRs
www.nature.com/articles/s41...
#iGluRs
www.nature.com/articles/s41...