Lewis Taylor
@l-w-taylor.bsky.social
2nd Year Neuroscience PhD Student in the Durrant Lab @ The University of Edinburgh.
Reposted by Lewis Taylor
🚨Meet the latest early career researchers awarded Race Against Dementia Fellowships🚨
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
November 20, 2025 at 9:52 AM
🚨Meet the latest early career researchers awarded Race Against Dementia Fellowships🚨
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RichardTaylor @sorayam.bsky.social @HelenRowland
Reposted by Lewis Taylor
www.biorxiv.org/content/10.1...
super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.
super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.
FMRP regulates adult human cortical excitability via cyclic-AMP signalling
Fragile X Syndrome (FXS) is a common inherited neurodevelopmental condition, resulting from loss of Fragile X Messenger Ribonuclear Protein (FMRP). Rodent models of FXS display cellular hyperexcitabil...
www.biorxiv.org
October 15, 2025 at 6:34 AM
www.biorxiv.org/content/10.1...
super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.
super excited to release this. nearly 7 years ago, we set out to investigate whether FMRP regulates excitability of neurons in living human brain tissue. we find loss of FMRP in adult neurons leads to elevated excitability, corrected by PDE4D inhibition.
Reposted by Lewis Taylor
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy - Nature Neuroscience
McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain via synapses.
www.nature.com
July 23, 2025 at 4:03 PM
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lewis Taylor
Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
July 17, 2025 at 11:54 AM
Delighted to share our paper examining synaptic tau in PSP. Many thanks to @robertmcgeachan.bsky.social @clairedurrant1.bsky.social and our many collaborators and funders. And extra special thanks to tissue donors who make this work possible.
Reposted by Lewis Taylor
See a lovely piece on STV highlighting the impacts of this disease on families . While our new findings will not lead to a new treatment today, we aim to bring hope to people living with PSP for the future news.stv.tv/east-central...
'People think my wife is drunk but she's living with a rare brain disease'
Edinburgh couple hope for treatment for rare neurological condition progressive supranuclear palsy.
news.stv.tv
July 17, 2025 at 11:56 AM
See a lovely piece on STV highlighting the impacts of this disease on families . While our new findings will not lead to a new treatment today, we aim to bring hope to people living with PSP for the future news.stv.tv/east-central...
Reposted by Lewis Taylor
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
July 16, 2025 at 1:10 PM
📢Fabulous new paper from @tspiresjones.bsky.social, @clairedurrant1.bsky.social & team describes new mechanisms in Progressive Supranuclear Palsy, suggesting that targeting tau in synapses is a promising approach for future treatments.
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Full paper➡️www.nature.com/articles/s41593-025-01992-5 🧠
Reposted by Lewis Taylor
Amazing work by the Booker lab here in Edinburgh! Another demonstration of the power of live human brain tissue 🧠.
What, what! We just published our work studying GABAB receptors in human and rat brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications
GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...
www.nature.com
May 7, 2025 at 8:21 AM
Amazing work by the Booker lab here in Edinburgh! Another demonstration of the power of live human brain tissue 🧠.
Reposted by Lewis Taylor
What, what! We just published our work studying GABAB receptors in human and rat brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Phylogenetic divergence of GABAB receptor signaling in neocortical networks over adult life - Nature Communications
GABAB receptors contribute to complex inhibition that regulates cortical neurons in a translationally relevant manner over adult life. Here, authors show stronger presynaptic inhibition in humans than...
www.nature.com
May 7, 2025 at 7:27 AM
What, what! We just published our work studying GABAB receptors in human and rat brain.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Lewis Taylor
Curious about how the brain might adapt to neurodegeneration? Come hear me talk about gold, guns and brain cells at @pintofscience.uk in Edinburgh! 🧠🍻 #pint25
The Resilient Mind: Fighting Against Dementia
Join us for an insightful event exploring the fascinating world of the brain. The first talk dives into the science of neurodegeneration, where brain cells…
pintofscience.co.uk
April 14, 2025 at 10:30 AM
Curious about how the brain might adapt to neurodegeneration? Come hear me talk about gold, guns and brain cells at @pintofscience.uk in Edinburgh! 🧠🍻 #pint25
Reposted by Lewis Taylor
Fantastic coverage of our recent work using living human brain slices to study Alzheimer’s disease from @itvnews.bsky.social
www.itv.com/news/2025-04...
www.itv.com/news/2025-04...
www.itv.com
April 30, 2025 at 3:38 PM
Fantastic coverage of our recent work using living human brain slices to study Alzheimer’s disease from @itvnews.bsky.social
www.itv.com/news/2025-04...
www.itv.com/news/2025-04...
Reposted by Lewis Taylor
Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...
Divergent actions of physiological and pathological amyloid-β on synapses in live human brain slice cultures - Nature Communications
Understanding synapse loss in Alzheimer’s disease has been hampered by a lack of human model systems. Here, the authors show that manipulation of physiological or pathological Aβ has differing effects...
www.nature.com
April 30, 2025 at 12:02 PM
Fantastic to see this work from @clairedurrant1.bsky.social group out in print! Important results using living human brain tissue to study Alzheimer’s disease www.nature.com/articles/s41...
Reposted by Lewis Taylor
Grateful for the chance to share my work at #BNA2025 yesterday 🧠 Loved all the insightful chats and feedback I received! @britishneuro.bsky.social @alzheimersresearchuk.org
April 30, 2025 at 9:14 AM
Grateful for the chance to share my work at #BNA2025 yesterday 🧠 Loved all the insightful chats and feedback I received! @britishneuro.bsky.social @alzheimersresearchuk.org
Reposted by Lewis Taylor
Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.
April 1, 2025 at 8:18 AM
Amazing to welcome HRH The Duchess of Edinburgh, Patron of Race Against Dementia to our lab! An incredible opportunity to showcase our work with living human brain slice cultures and the importance of investing in dementia research. We are very lucky to have her support.
Reposted by Lewis Taylor
We just published a thing!
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
www.nature.com
January 7, 2025 at 10:22 AM
We just published a thing!
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function.
www.nature.com/articles/s41...
Reposted by Lewis Taylor
Paper acceptance mornings are the best!!!!! :) Watch this space 💃🏽💃🏽💃🏽
January 8, 2025 at 10:27 AM
Paper acceptance mornings are the best!!!!! :) Watch this space 💃🏽💃🏽💃🏽