Anastasia Kuzkina
@kuzkina.bsky.social
Reposted by Anastasia Kuzkina
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator loss leads to dsRNA formation that triggers the integrated stress response
Integrator (INT) prevents the escape of immature RNAPII to ensure full-length mRNA production. INT deficiency causes defects in RNAPII maturation that lead to premature termination, accumulation of immunogenic dsRNA, and activation of the integrated stress response (ISR) observed in patient cells.
dlvr.it
April 14, 2025 at 10:38 PM
Now online! Integrator loss leads to dsRNA formation that triggers the integrated stress response
Reposted by Anastasia Kuzkina
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:
April 14, 2025 at 4:56 PM
Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes: