Karolina Kuodyte
@kuodyte.bsky.social
Postdoc in Grapin-Botton group @MPICBG - Pancreatic Acinar Organoids| PhD @EMBL and @UniHeidelberg
I’m very excited to share that our paper has been recently published in Cell Stem Cell! 🎉 🧫
In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.
doi.org/10.1016/j.st...
In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.
doi.org/10.1016/j.st...
February 4, 2026 at 5:05 PM
I’m very excited to share that our paper has been recently published in Cell Stem Cell! 🎉 🧫
In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.
doi.org/10.1016/j.st...
In this study, using high-content imaging–based organoid screening, we discovered growth media conditions that drive differentiation into functional pancreatic acinar cells.
doi.org/10.1016/j.st...
Reposted by Karolina Kuodyte
The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...
Making human pancreatic acinar cells
Dresden researchers develop novel methods to create acinar cells, which are involved in the formation of pancreatic cancer.
www.mpi-cbg.de
January 21, 2026 at 4:33 PM
The group of @anne-grapin.bsky.social developed methods to create functional acinar cells, which are involved in the formation of pancreatic cancer. Rashmiparvathi Keshara, Karolina Kuodyte, and the TDS facility used image-based screen & robust analysis pipeline. www.mpi-cbg.de/news-outreac...
Reposted by Karolina Kuodyte
Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells
High-content screening of organoids reveals the mechanisms of human pancreas acinar specification
Keshara et al. conducted a high-content screen on pancreas organoids that identified 54 compounds affecting differentiation or morphogenesis. After validating 11 compounds, they focus on Gsk3A/B inhibitors, which, combined with FGF withdrawal, drive acinar cell differentiation, enabling future studies on these cells and their role in cancer initiation in humans.
dlvr.it
January 21, 2026 at 8:09 PM
Online Now! High-content screening of organoids reveals the mechanisms of human pancreas acinar specification #stemcells
Reposted by Karolina Kuodyte
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness - Nature Cell Biology
Moghe et al. show that mouse embryonic primitive endoderm cells migrate towards the inner cell mass-cavity interface, depositing an extracellular matrix gradient that may guide migration. Primitive en...
nature.com
February 18, 2025 at 10:07 AM
Delighted to share that my PhD work from the Hiiragi Lab is now published in Nature Cell Biology! We uncover the cellular mechanisms underlying pattern formation and how patterning robustness can be ensured during embryo development. Check out the full story: nature.com/articles/s41556-025-01618-9