Kufer Lab , Department of Immunology
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Kufer Lab , Department of Immunology
@kufer-lab.bsky.social
Department of Immunology
Institute of Nutritional Medicine
#unihohenheim
#immunosky

https://immu.uni-hohenheim.de/en
Very nice review article on NLRP3 from Alex Weber et al. online!

The expanding role of the NLRP3
inflammasome from periodic fevers to
therapeutic targets

doi.org/10.1038/s415...
The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets - Nature Immunology
Latz et al. review the molecular mechanisms that drive NLRP3 inflammasome activation and regulation, and discuss emerging targeting strategies.
doi.org
September 2, 2025 at 6:15 AM
We are proud to present first data on our CAPE study at the #IUIS2025 in Vienna this week.
Come and discuss with us at Lucy’s poster
“Postprandial dynamic of immune cell responses and serum concentration of PRR ligands in humans”
Thursday, 21 August 2025, 12:15 - 13:45
Poster III.366
August 17, 2025 at 11:32 AM
Reposted by Kufer Lab , Department of Immunology
Warm invitation to the DGfI Autumn School! 💡 Deadline for application: July 31, 2025

The DGfI Autumn School invites you to embark on an up-to-date educational journey through the immune system.
dgfi.org/akademie-fue...

Registration: dgfi.org/akademie-fue...
Program: dgfi.org/wp-content/u...
July 23, 2025 at 4:30 PM
Lucy's first paper on our RESIST PP project, describing a sensitive bioassay to measure NOD1/2 ligands in serum and differential postprandial NOD2 activation has been published!
Congratulations!
doi.org/10.3389/fnut...
June 25, 2025 at 6:18 AM
Reposted by Kufer Lab , Department of Immunology
Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.
Corona: Neue Variante NB.1.8.1, Impfung, Long Covid - Experte von der Charité klärt auf
Weltweit breitet sich eine neue Coronavariante aus. Der Infektiologe Leif Erik Sander sagt, was inzwischen über die Risiken einer Covid-Erkrankung bekannt ist und wer sich noch mal impfen lassen sollte.
www.spiegel.de
June 20, 2025 at 4:49 PM
Reposted by Kufer Lab , Department of Immunology
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization.

Out @natgenet.nature.com:

rdcu.be/eqGgf
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
rdcu.be
June 12, 2025 at 2:14 PM
Timo Voss from our group will present news on NLP10 at the #NCII in Tübingen.
Have a look at poster # P041

innate-immunity-conference.de
NCII: Novel concepts in innate immunity
innate-immunity-conference.de
June 6, 2025 at 11:59 AM
Next week the Novel Concepts in Innate Immunity Syposium in Tübingen starts!

Great line of Speakers put together by Alex Weber.

innate-immunity-conference.de
NCII: Novel concepts in innate immunity
innate-immunity-conference.de
June 2, 2025 at 6:21 AM
🗣️Our EMBO Lecture Course
"Cell-autonomous defense and innate immunity"
now is open for registration.
We are proud to present an excellent line of speakers!
Join us in India!
👇
meetings.embo.org/event/25-imm...
Cell-autonomous defense and innate immunity
Cell-autonomous defense encompasses the inherent mechanisms of the cell that allow individual cells to protect themselves from infectious and inflammatory dangers. Recent advancements in the field in…
meetings.embo.org
May 15, 2025 at 10:02 AM
Reposted by Kufer Lab , Department of Immunology
Great Promethion-powered research from Anja Bosy-Westphal & colleagues @ Kiel University – “short-term consumption of protein-enriched UPFs did not prevent overeating but did favourably affect energy partitioning”! 🧪 www.nature.com/articles/s42...
Short-term effects of high-protein, lower-carbohydrate ultra-processed foods on human energy balance - Nature Metabolism
This single-blind crossover trial shows that the short-term consumption of protein-enriched ultra-processed foods does not prevent overeating but favourably affects energy partitioning.
www.nature.com
March 31, 2025 at 7:12 PM
Annual Meeting of our RESIST-PP consortium.

Having an intense and interesting meeting in Murcia, Spain.
Thanks to Pablo Pelegrin for perfect organization.
May 8, 2025 at 2:11 PM
Rho GTPases emerge as more general regulators if NLR proteins. See news on Rac2 and Nlrp3.
The Boyer group @lauboye.bsky.social show NLRP3 #inflammasome activation in circulating myeloid cells by human RAC2 gain-of-function variants that are linked to rare immune disorders. rupress.org/jem/article/...

📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025
April 11, 2025 at 7:30 AM
Prof. Wagner and Team are developing nice games to teach immunology.
lnkd.in/e5AKif6w

Check it out: 😀👍
lnkd.in/eHPRakb7

#immunosky
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
April 10, 2025 at 6:26 AM
Reposted by Kufer Lab , Department of Immunology
With this #rothenfels2025 has come to an end🏁 Thanks to everyone who came and contributed with talks and discussions and fun and made it this special type of meeting🤩😎 Hope to CU again next year for #rothenfels2026 on March 16 to 18 - mark your calendars!📅
@dgfi-yi.bsky.social @dgfi-org.bsky.social
March 26, 2025 at 9:03 PM
Dixon et al. identified ABHD17 enzymes as negative regulators of NOD2 that affect its membrane localization. 🔬
See my comment for details👇
doi.org/10.1016/j.jc...
Redirecting
doi.org
March 29, 2025 at 2:36 PM
Reposted by Kufer Lab , Department of Immunology
🥳 We achieved our first Milestone with HDHL #Food4Health!

The main objective is to align R&I priorities among funding programmes by identifying research and policy needs to overcome the siloed approach between health & nutrition.
Interested in the specific objectives of this project?
bit.ly/3QOqX9Q
March 28, 2025 at 11:13 AM
Santosh Chauhan and friends put together a great line of speakers for the
EMBO Conference "Cell-autonomous defense and innate immunity"🎤
3–5 December 2025 | IN-Hyderabad

More news coming soon... Stay tuned!
👇👇
coming-soon.embo.org/ielc25-02
Cell-autonomous Defense and innate immunity
coming-soon.embo.org
March 28, 2025 at 8:57 AM
What the sh*t did I eat?

"Metagenomic estimation of dietary intake from human stool"
Interesting news. Can we finally really say what I person eat?

www.nature.com/articles/s42...
Metagenomic estimation of dietary intake from human stool - Nature Metabolism
Diener et al. present a method that allows the estimation of dietary intake from human stool by detecting food-derived DNA in faecal metagenomes.
www.nature.com
March 28, 2025 at 8:49 AM
Reposted by Kufer Lab , Department of Immunology
And keynote speaker of day 2 Karsten Hiller of @tubraunschweig.bsky.social is giving us a deep dive into immuno metabolism in macrophages: #itaconate rules ✌🏻🤓 #Rothenfels2025
March 25, 2025 at 9:31 PM
Timo Voss from our group presented news on NLRP10 at the Burg Rothenfels Meeting.
Very nice and interactive event! #DGfI
March 25, 2025 at 10:32 AM
Reposted by Kufer Lab , Department of Immunology
#immunosky #microbiomesky FREE LINK @cp-immunity.bsky.social!
Fat diet, dysbiosis, inflammation & chemicals induce gut barrier disruption! Systemic dissemination of gut microbiota mediates a Mincle-dependent induction of trained immunity in myeloid bone marrow cells
www.cell.com/immunity/ful...
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenito...
www.cell.com
January 23, 2025 at 11:04 AM
Reposted by Kufer Lab , Department of Immunology
A rare & debilitating group of #AutoinflammatoryDiseases, Cryopyrin-associated periodic syndromes (CAPS), is closer to a cure thanks to a world first genetic analysis project. 🔥

Read more about Shouya Feng & Prof Seth Masters' study in journal Nature Immunology, or here: bit.ly/4ilMYsg
March 4, 2025 at 6:27 AM
Nice Research Topic of "Methods in molecular innate immunity" now available at!
See our editorial👇👇👇
www.frontiersin.org/journals/imm...
Frontiers | Editorial: Methods in molecular innate immunity: 2022
Advances in immunology are inherently linked to progress in implementing novel methods as best illustrated by the development of the cre-lox technique that a...
www.frontiersin.org
March 18, 2025 at 10:42 AM
It was great to meet the colleagues from the other projects!
Very nice interactive and informative day in Paris.
Thanks HDHL for the organization.
Last month, we organised the NUTRIMMUNE mid-term symposium, where six projects showcased their progress.

The symposium created the perfect space for researchers to connect🤝, exchange ideas💡, and foster new collaborations🌱.

Read more 👉 bit.ly/43KLdke
March 17, 2025 at 9:34 PM
Reposted by Kufer Lab , Department of Immunology
Last month, we organised the NUTRIMMUNE mid-term symposium, where six projects showcased their progress.

The symposium created the perfect space for researchers to connect🤝, exchange ideas💡, and foster new collaborations🌱.

Read more 👉 bit.ly/43KLdke
March 13, 2025 at 2:13 PM