Ko-Fan Chen 陳克帆
@kofanchen.biologists.social.ap.brid.gy
Working with #Drosophila to understand #sleep and #circadian rhythm. Lecturer in #Neurogenetics at University of #Leicester
🌉 bridged from ⁂ https://biologists.social/@kofanchen, follow @ap.brid.gy to interact
🌉 bridged from ⁂ https://biologists.social/@kofanchen, follow @ap.brid.gy to interact
So, what did we find?
1) Strikingly, seven of the eight tested mutants with mutations in four different phototransduction genes showed less sleep or shorter sleep bouts in the day.
2) artificially hyperpolarising eye photoreceptor also cause similar sleep […]
[Original post on biologists.social]
1) Strikingly, seven of the eight tested mutants with mutations in four different phototransduction genes showed less sleep or shorter sleep bouts in the day.
2) artificially hyperpolarising eye photoreceptor also cause similar sleep […]
[Original post on biologists.social]
November 4, 2025 at 11:14 AM
So, what did we find?
1) Strikingly, seven of the eight tested mutants with mutations in four different phototransduction genes showed less sleep or shorter sleep bouts in the day.
2) artificially hyperpolarising eye photoreceptor also cause similar sleep […]
[Original post on biologists.social]
1) Strikingly, seven of the eight tested mutants with mutations in four different phototransduction genes showed less sleep or shorter sleep bouts in the day.
2) artificially hyperpolarising eye photoreceptor also cause similar sleep […]
[Original post on biologists.social]
To make sure the mutants we acquired retain their defects in phototransduction, the first author Yu-Chien Hung teamed up with Ben Warren at Keele University to record electroretinogram.
4/8
4/8
November 4, 2025 at 11:10 AM
To make sure the mutants we acquired retain their defects in phototransduction, the first author Yu-Chien Hung teamed up with Ben Warren at Keele University to record electroretinogram.
4/8
4/8
This is perhaps not surprising as vision are known to maintain one’s wakefulness and the same time providing sleep drive.
We therefore decided to look at the sleep profiles for all the classic mutant lines that affects phototransduction, plus those with […]
[Original post on biologists.social]
We therefore decided to look at the sleep profiles for all the classic mutant lines that affects phototransduction, plus those with […]
[Original post on biologists.social]
November 4, 2025 at 11:09 AM
This is perhaps not surprising as vision are known to maintain one’s wakefulness and the same time providing sleep drive.
We therefore decided to look at the sleep profiles for all the classic mutant lines that affects phototransduction, plus those with […]
[Original post on biologists.social]
We therefore decided to look at the sleep profiles for all the classic mutant lines that affects phototransduction, plus those with […]
[Original post on biologists.social]
I am glad to say that the first manuscript from the lab is now available on BioRxiv
https://www.biorxiv.org/content/10.1101/2025.10.30.685496v1
We set out to answer a simple question:
If the fruit fly #drosophila cannot see clearly, how would they #sleep?
https://www.biorxiv.org/content/10.1101/2025.10.30.685496v1
We set out to answer a simple question:
If the fruit fly #drosophila cannot see clearly, how would they #sleep?
November 4, 2025 at 11:05 AM
I am glad to say that the first manuscript from the lab is now available on BioRxiv
https://www.biorxiv.org/content/10.1101/2025.10.30.685496v1
We set out to answer a simple question:
If the fruit fly #drosophila cannot see clearly, how would they #sleep?
https://www.biorxiv.org/content/10.1101/2025.10.30.685496v1
We set out to answer a simple question:
If the fruit fly #drosophila cannot see clearly, how would they #sleep?
#phd #academicchatter
Went out for a quick after work drink celebratjng my first lab paper (a thread will follow ) with my PhD contemporary @carlobreda
It's nice to share good and bad times and remember how long we have come since the day we are locked at #euclock #circadian meeting
Went out for a quick after work drink celebratjng my first lab paper (a thread will follow ) with my PhD contemporary @carlobreda
It's nice to share good and bad times and remember how long we have come since the day we are locked at #euclock #circadian meeting
October 30, 2025 at 6:47 PM
#phd #academicchatter
Went out for a quick after work drink celebratjng my first lab paper (a thread will follow ) with my PhD contemporary @carlobreda
It's nice to share good and bad times and remember how long we have come since the day we are locked at #euclock #circadian meeting
Went out for a quick after work drink celebratjng my first lab paper (a thread will follow ) with my PhD contemporary @carlobreda
It's nice to share good and bad times and remember how long we have come since the day we are locked at #euclock #circadian meeting
We also got a brand new #insect pushing room for #drosophila and #nasonia at @NeurogeneticsLeicester 🤩🤩🤩🤩
October 1, 2025 at 7:06 PM
We also got a brand new #insect pushing room for #drosophila and #nasonia at @NeurogeneticsLeicester 🤩🤩🤩🤩
Our lab move is almost complete, the new lab is taking shape! Thanks to the team effort from Yu-Chien, Mehran @mehranakhtar Xinghua @lixinghua
October 1, 2025 at 4:06 PM
Our lab move is almost complete, the new lab is taking shape! Thanks to the team effort from Yu-Chien, Mehran @mehranakhtar Xinghua @lixinghua
#academicchatter sometimes I think my work schedule is mysteriously annoying: we are moving neurogenetic labs to the new buildings next week overlaps with two external deadlines and semester UG research project starting! (yes everything is everywhere at […]
[Original post on biologists.social]
[Original post on biologists.social]
September 26, 2025 at 8:06 AM
#academicchatter sometimes I think my work schedule is mysteriously annoying: we are moving neurogenetic labs to the new buildings next week overlaps with two external deadlines and semester UG research project starting! (yes everything is everywhere at […]
[Original post on biologists.social]
[Original post on biologists.social]
And back
August 29, 2025 at 4:46 PM
And back
Onwards back to Europe Star! ✨
August 29, 2025 at 11:34 AM
Onwards back to Europe Star! ✨
August 28, 2025 at 6:42 AM
Good day at #ebrs @mehranakhtar gave a good talk explaining novel sleep promoting role of histaminergic output from #drosophila photoreceptors and had a good lab dinner sampling Afghanistan cusin at Luebeck!
#sleep #circadian
#sleep #circadian
August 26, 2025 at 10:00 PM
Good day at #ebrs @mehranakhtar gave a good talk explaining novel sleep promoting role of histaminergic output from #drosophila photoreceptors and had a good lab dinner sampling Afghanistan cusin at Luebeck!
#sleep #circadian
#sleep #circadian
And I am here
August 24, 2025 at 2:37 PM
And I am here
And Hamburg
August 24, 2025 at 12:08 PM
And Hamburg
Onwards journey to Luebeck
August 24, 2025 at 8:28 AM
Onwards journey to Luebeck
Zeppelin!
August 22, 2025 at 3:42 PM
Zeppelin!
Passing #köln
August 22, 2025 at 2:30 PM
Passing #köln
July 9, 2025 at 4:05 PM
Hello biologists.social!
I just moved here, I am working on sleep and circadian rhythm using #drosophila, hope to continue engaing with the drosophila researchers and wider community here!
I just moved here, I am working on sleep and circadian rhythm using #drosophila, hope to continue engaing with the drosophila researchers and wider community here!
July 4, 2025 at 5:47 PM
Hello biologists.social!
I just moved here, I am working on sleep and circadian rhythm using #drosophila, hope to continue engaing with the drosophila researchers and wider community here!
I just moved here, I am working on sleep and circadian rhythm using #drosophila, hope to continue engaing with the drosophila researchers and wider community here!