Kaden Southard
kmsouthard.bsky.social
Kaden Southard
@kmsouthard.bsky.social
Post-doc @normanlab.bsky.social MSKCC
Reposted by Kaden Southard
💫PUBLISHED @natgenet.nature.com

📰Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states.

By Kaden M. Southard, @normanlab.bsky.social and colleagues!

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www.nature.com/articles/s41...
Comprehensive transcription factor perturbations recapitulate fibroblast transcriptional states - Nature Genetics
CRISPR activation of 1,836 human transcription factors recapitulates fibroblast transcriptional states observed in vivo and identifies regulators that can revert inflammatory states.
www.nature.com
August 27, 2025 at 1:26 PM
Reposted by Kaden Southard
Excited to announce the opening of the @fitzsimmonslab.bsky.social at @michiganstateu.bsky.social dept. of biochemistry & molecular biology! (1/3)
August 25, 2025 at 8:35 PM
Reposted by Kaden Southard
Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.
August 6, 2025 at 3:14 PM