Kylie Lange
@klange-au.bsky.social
Statistician working in clinical trials methodology & nutrition and diabetes clinical research | South Australian Health & Medical Research Institute (SAHMRI); The University of Adelaide
Pinned
Kylie Lange
@klange-au.bsky.social
· Nov 15
Partially clustered designs for clinical trials: Unifying existing designs using consistent terminology - Kylie M Lange, Jessica Kasza, Thomas R Sullivan, Lisa N Yelland, 2023
Introduction: Clinical trial designs based on the assumption of independent observations are well established. Clustered clinical trial designs, where all obser...
journals.sagepub.com
My PhD research is on statistical issues in partially clustered clinical trials - these are trials that involve both independent and clustered observations. Check out this paper for details on where they occur and how we should be describing them: journals.sagepub.com/doi/10.1177/... (1/3)
Reposted by Kylie Lange
This week! Prof Ian Marschner from the NHMRC Clinical Trials Centre will be presenting the @vicbiostat.bsky.social seminar on Confidence distributions.
All welcome online or in person.
Friday 21 November 9:30am AEDT, Monash SPHPM.
www.vicbiostat.org.au/event/confid...
All welcome online or in person.
Friday 21 November 9:30am AEDT, Monash SPHPM.
www.vicbiostat.org.au/event/confid...
Confidence distributions: new tools to design, adapt and analyse clinical trials
Confidence distributions provide a holistic s
www.vicbiostat.org.au
November 16, 2025 at 9:54 PM
This week! Prof Ian Marschner from the NHMRC Clinical Trials Centre will be presenting the @vicbiostat.bsky.social seminar on Confidence distributions.
All welcome online or in person.
Friday 21 November 9:30am AEDT, Monash SPHPM.
www.vicbiostat.org.au/event/confid...
All welcome online or in person.
Friday 21 November 9:30am AEDT, Monash SPHPM.
www.vicbiostat.org.au/event/confid...
Time for some updates!
🎓Celebrated the official end of my PhD journey with graduation from The University of Adelaide. PhDONE!
💼Now fully settled in as a postdoc in the Biostatistics Unit at @sahmri.bsky.social
⚕️Pleased to also be continuing my role supporting clinical research at UofA
🎓Celebrated the official end of my PhD journey with graduation from The University of Adelaide. PhDONE!
💼Now fully settled in as a postdoc in the Biostatistics Unit at @sahmri.bsky.social
⚕️Pleased to also be continuing my role supporting clinical research at UofA
October 10, 2025 at 6:53 AM
Time for some updates!
🎓Celebrated the official end of my PhD journey with graduation from The University of Adelaide. PhDONE!
💼Now fully settled in as a postdoc in the Biostatistics Unit at @sahmri.bsky.social
⚕️Pleased to also be continuing my role supporting clinical research at UofA
🎓Celebrated the official end of my PhD journey with graduation from The University of Adelaide. PhDONE!
💼Now fully settled in as a postdoc in the Biostatistics Unit at @sahmri.bsky.social
⚕️Pleased to also be continuing my role supporting clinical research at UofA
I'm looking forward to going to Melbourne for this - it promises to be a great meeting!
Join us at the 3rd biennial Australian Trials Methodology Conference as we explore "Better trials through better methods"
Crown Promenade, Melbourne (+ online access options)
20/11/25
Early-bird registration ends 26/9
www.atmc25.com
#ClinicalTrials #Biostatistics
Crown Promenade, Melbourne (+ online access options)
20/11/25
Early-bird registration ends 26/9
www.atmc25.com
#ClinicalTrials #Biostatistics
September 15, 2025 at 5:12 AM
I'm looking forward to going to Melbourne for this - it promises to be a great meeting!
Reposted by Kylie Lange
📢 Australian Trials Methodology Conference 2025
🗓 20 Nov | 📍Melbourne & Online via Zoom
Join leading speakers from academia, industry & healthcare.
🎟 Early-bird rates until 26 Sep!
🔗Register: atmc25.com
#ClinicalTrials #TrialMethodology #Biostatistics
@vicbiostat.bsky.social
🗓 20 Nov | 📍Melbourne & Online via Zoom
Join leading speakers from academia, industry & healthcare.
🎟 Early-bird rates until 26 Sep!
🔗Register: atmc25.com
#ClinicalTrials #TrialMethodology #Biostatistics
@vicbiostat.bsky.social
August 25, 2025 at 5:18 AM
📢 Australian Trials Methodology Conference 2025
🗓 20 Nov | 📍Melbourne & Online via Zoom
Join leading speakers from academia, industry & healthcare.
🎟 Early-bird rates until 26 Sep!
🔗Register: atmc25.com
#ClinicalTrials #TrialMethodology #Biostatistics
@vicbiostat.bsky.social
🗓 20 Nov | 📍Melbourne & Online via Zoom
Join leading speakers from academia, industry & healthcare.
🎟 Early-bird rates until 26 Sep!
🔗Register: atmc25.com
#ClinicalTrials #TrialMethodology #Biostatistics
@vicbiostat.bsky.social
📣New publication alert! The latest paper from my PhD is now online at Statistics in Medicine, presenting new sample size formulas for clinical trials that include partial clustering. Really happy to see this work out in the world! 🧵1/4
dx.doi.org/10.1002/sim....
dx.doi.org/10.1002/sim....
Sample Size Calculations for Partially Clustered Trials
Partially clustered trials are defined as trials where some observations belong to a cluster and others are independent. For example, neonatal trials may include infants from a single, twin, or tripl...
dx.doi.org
July 28, 2025 at 8:22 AM
📣New publication alert! The latest paper from my PhD is now online at Statistics in Medicine, presenting new sample size formulas for clinical trials that include partial clustering. Really happy to see this work out in the world! 🧵1/4
dx.doi.org/10.1002/sim....
dx.doi.org/10.1002/sim....
Reposted by Kylie Lange
I'm looking for a senior research fellow or research fellow to join my group (the Cluster Cluster!) at Monash University, to develop statistical methodology of adaptive longitudinal cluster randomised trials. Come join us for 3 years in marvellous Melbourne! careers.pageuppeople.com/513/cw/en/jo...
May 26, 2025 at 9:22 PM
I'm looking for a senior research fellow or research fellow to join my group (the Cluster Cluster!) at Monash University, to develop statistical methodology of adaptive longitudinal cluster randomised trials. Come join us for 3 years in marvellous Melbourne! careers.pageuppeople.com/513/cw/en/jo...
Reposted by Kylie Lange
New #preprint with @nicolewhite.bsky.social and @tayacollyer.bsky.social. We examined if Australian ethics committees use qualified statistical expertise. Our results revealed a large variation in practice, with some committees using qualified statisticians […] (1 of 4)
osf.io/preprints/os...
osf.io/preprints/os...
OSF
osf.io
January 31, 2025 at 3:01 AM
New #preprint with @nicolewhite.bsky.social and @tayacollyer.bsky.social. We examined if Australian ethics committees use qualified statistical expertise. Our results revealed a large variation in practice, with some committees using qualified statisticians […] (1 of 4)
osf.io/preprints/os...
osf.io/preprints/os...
One of the motivating examples of partial clustering for my PhD research is the inclusion of infants from multiple births in neonatal trials. Kristy Robledo has just published a review of how multiple births are dealt with in these trials - and the news isn't great! 1/2
fn.bmj.com/content/earl...
fn.bmj.com/content/earl...
We should do better in accounting for multiple births in neonatal randomised trials: a methodological systematic review
Objective To conduct a methodological systematic review of multicentre trials of premature infants to (1) determine if and how multiple births have been considered in the design, analysis and reportin...
fn.bmj.com
December 11, 2024 at 6:12 AM
One of the motivating examples of partial clustering for my PhD research is the inclusion of infants from multiple births in neonatal trials. Kristy Robledo has just published a review of how multiple births are dealt with in these trials - and the news isn't great! 1/2
fn.bmj.com/content/earl...
fn.bmj.com/content/earl...
My PhD research is on statistical issues in partially clustered clinical trials - these are trials that involve both independent and clustered observations. Check out this paper for details on where they occur and how we should be describing them: journals.sagepub.com/doi/10.1177/... (1/3)
Partially clustered designs for clinical trials: Unifying existing designs using consistent terminology - Kylie M Lange, Jessica Kasza, Thomas R Sullivan, Lisa N Yelland, 2023
Introduction: Clinical trial designs based on the assumption of independent observations are well established. Clustered clinical trial designs, where all obser...
journals.sagepub.com
November 15, 2024 at 12:44 AM
My PhD research is on statistical issues in partially clustered clinical trials - these are trials that involve both independent and clustered observations. Check out this paper for details on where they occur and how we should be describing them: journals.sagepub.com/doi/10.1177/... (1/3)