Investigating whether this locomotion-induced haemodynamic response was altered in disease, we showed AD mice (APP/PS1) had a smaller HbT decrease in the draining vein than mixed disease mice (APP/PS1 combined with atherosclerosis, MIX).

When we looked at overlying meningeal vessels (MN), we also observed a decrease in HbT at the onset of locomotion, which unlike within the draining vein (which is contained within the cortex) did not go on to exceed baseline HbT levels for the remainder of the locomotion response.

We show locomotion evokes an initial decrease in total haemoglobin (HbT) in the draining vein, before the WBR HbT increase. Whilst the size of the locomotion event impacts the HbT response magnitude within WBR vessels, this is not true for the early HbT decrease within the draining veins (DV).

In this follow-up study we have extended our work investigating the impact of locomotion on haemodynamic responses to look across the different vascular compartments.

Imaging in a dark room when it’s sunny outside is worth it for beautiful vessels 😍 (🟢green is methoxy label of CAA). #twophoton #alzheimers #imaging

Dementia devastates the lives of everyone it touches, but this #internationalwomensday let’s highlight the impact it has on women: www.alzheimersresearchuk.org/about-us/our...