Kevin Johnson
@kevin-johnson.bsky.social
Research Scientist in Department of Neurosurgery Yale University studying glioma evolution
Reposted by Kevin Johnson
This 7-year journey has reached a first milestone! 🥳 Excited to share our preprint (3rd of 2025) on the 3D telomeric interactome, a project that started with a K99 in 2018. Thanks to Yi-An Chen, first postdoc in our lab and first author who worked tirelessly to realize this dream. bit.ly/3W3wuMk
Mapping the Telomeric 3D Interactome with Telomere-C Reveals Repetitive Element Hubs Associated with Telomere Maintenance
Telomeres are essential for genome integrity, but the accurate, high-resolution mapping of their three-dimensional (3D) chromatin interactions, a process thought to mediate gene regulation and telomer...
bit.ly
October 13, 2025 at 11:21 PM
This 7-year journey has reached a first milestone! 🥳 Excited to share our preprint (3rd of 2025) on the 3D telomeric interactome, a project that started with a K99 in 2018. Thanks to Yi-An Chen, first postdoc in our lab and first author who worked tirelessly to realize this dream. bit.ly/3W3wuMk
Reposted by Kevin Johnson
Online Now: Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis
Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis
Tang et al. apply spatiotemporal multi-omics to define four proteomic subtypes of IDH-mutant astrocytoma. They highlight an immune/mesenchymal-enriched (IME) subtype marked by gemistocytic differentiation, immune infiltration, and poor prognosis. Their AI-powered toolbox, GUIDE, enables multi-omics-based classification and supports precision diagnostics in glioma care.
dlvr.it
September 15, 2025 at 6:52 PM
Online Now: Protein-based classification reveals an immune-hot subtype in IDH mutant astrocytoma with worse prognosis
Reposted by Kevin Johnson
Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profil...
www.biorxiv.org
September 16, 2025 at 8:00 AM
Precision medicine in high-grade gliomas? Using high-throughput drug screen in #NORLUX patient-derived organoids multi-omics and machine learning, we assessed pharmacogenomics: www.biorxiv.org/content/10.1...
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
@fnr.lu, #precisionmedicine, #organoids, #drugscreen, #pharmacogenomics, #braintumors
Reposted by Kevin Johnson
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
May 16, 2025 at 11:44 AM
How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 new studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. multimodal cell atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵
Reposted by Kevin Johnson
1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics - Nature Genetics
Comparison of paired primary and recurrent glioblastomas at the single-cell transcriptomic level describes molecular and cellular trajectories associated with tumor recurrence, highlighting extensive ...
www.nature.com
May 10, 2025 at 10:57 PM
1/ Truly excited to share our new study that I had to privilege to co-lead during my PhD alongside great friends and collaborators @masashi-nomura.bsky.social, @kevin-johnson.bsky.social and Luciano Garofano, published at Nature Genetics @natureportfolio.nature.com!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kevin Johnson
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
The multilayered transcriptional architecture of glioblastoma ecosystems - Nature Genetics
Integrated single-cell transcriptomic and genetic characterization of 121 adult glioblastomas identifies heterogeneity at cell type, cell state and baseline expression program levels associated with s...
www.nature.com
May 9, 2025 at 10:14 AM
1/ Thrilled to share our TWO back-to-back papers published in Nature Genetics today! www.nature.com/articles/s41... , www.nature.com/articles/s41...
Reposted by Kevin Johnson
We are looking to recruit new postdocs! Please check verhaaklab.com/archive/2025....
postdoc opportunity - join our team! · Verhaak Lab
The Verhaak lab in the Department of Neurosurgery at the Yale School of Medicine is looking to recruit a postdoctoral associate who will help us develop new therapeutic approaches to treat patients wi...
verhaaklab.com
March 20, 2025 at 2:05 PM
We are looking to recruit new postdocs! Please check verhaaklab.com/archive/2025....
Reposted by Kevin Johnson
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma
Nature Cell Biology - Sojka et al. analyse the transcriptomic and epigenomic landscape of human astrocyte maturation and identify an epigenetically regulated intermediate state associated with...
rdcu.be
January 8, 2025 at 5:13 PM
First 🦋 post! Very excited to share our lab's latest work exploring the shared and divergent aspects of human astrocyte development and glioblastoma. This effort spans many fields from developmental #glial biology to #stem cells and #tumor biology. rdcu.be/d5ADz A 🧵