Keling Wang
@keling-wang.com
PhD student @ Erasmus MC Rotterdam, NL
Epidemiology and causal inference.
Beagles rule the world.
Epidemiology and causal inference.
Beagles rule the world.
And the controversy was around CVD. AND back to the topic, ref. www.thelancet.com/journals/lan..., journals.lww.com/epidem/fullt... and pubmed.ncbi.nlm.nih.gov/18854702/. Back to Jeremy's post, had they seriously considered their 'association studies', these discussion wouldn't have been here...
Observational studies analyzed like randomized experiments: an application to postmenopausal hormone therapy and coronary heart disease - PubMed
Our findings suggest that the discrepancies between the Women's Health Initiative and Nurses' Health Study ITT estimates could be largely explained by differences in the distribution of time since menopause and length of follow-up.
pubmed.ncbi.nlm.nih.gov
November 29, 2025 at 5:00 PM
And the controversy was around CVD. AND back to the topic, ref. www.thelancet.com/journals/lan..., journals.lww.com/epidem/fullt... and pubmed.ncbi.nlm.nih.gov/18854702/. Back to Jeremy's post, had they seriously considered their 'association studies', these discussion wouldn't have been here...
I agree [effect of HRT on life expectancy (or survival, bc life expectancy is a population-level indicator)] would be negligible compared to other possible biopolitical/environmental exposures. Still though discussion was not centered around [survival] but overall utility and costeff. of decision.
November 29, 2025 at 4:54 PM
I agree [effect of HRT on life expectancy (or survival, bc life expectancy is a population-level indicator)] would be negligible compared to other possible biopolitical/environmental exposures. Still though discussion was not centered around [survival] but overall utility and costeff. of decision.
The story of HRT didn’t stop here tho. It’s more diff. in population, time horizon, initiation and types (oral vs parenteral, natural vs. synthetic) leads to discrepancy in '90s-obs studied and trials (namely WHI). This is exactly why ppl shouldn't say "hey my RCT is nonsig so all others are wrong"
November 29, 2025 at 1:26 PM
The story of HRT didn’t stop here tho. It’s more diff. in population, time horizon, initiation and types (oral vs parenteral, natural vs. synthetic) leads to discrepancy in '90s-obs studied and trials (namely WHI). This is exactly why ppl shouldn't say "hey my RCT is nonsig so all others are wrong"
How do you know I was trying to propose submitting our protocol and other pieces around mid-December😂😂😂😂
November 28, 2025 at 4:29 PM
How do you know I was trying to propose submitting our protocol and other pieces around mid-December😂😂😂😂
Forgot to post this article that talks precisely about what i wanna criticize against Cass ppl. link.springer.com/article/10.1... Research articles and position statements are unavoidably affected by politics but also affecting and guiding future biopolitical discussion. Think about consequences.
A Critique of the Cass Review and the Implications of “Gender Restrictive Care” - Archives of Sexual Behavior
A University of York review of research supporting gender affirming care (GAC) of gender dysphoric children and adolescents suggested that the research was of such poor quality that it could endanger ...
link.springer.com
November 25, 2025 at 2:15 PM
Forgot to post this article that talks precisely about what i wanna criticize against Cass ppl. link.springer.com/article/10.1... Research articles and position statements are unavoidably affected by politics but also affecting and guiding future biopolitical discussion. Think about consequences.
Even, is the problem really lying within "methodological limitations"? No it's NOT. You evidence based medicine followers' pre-modern minds and research paradigms are completely INCAPABLE of doing anything about trans care if you are completely uneducated in basic sociology and gender theory.
November 25, 2025 at 6:58 AM
Even, is the problem really lying within "methodological limitations"? No it's NOT. You evidence based medicine followers' pre-modern minds and research paradigms are completely INCAPABLE of doing anything about trans care if you are completely uneducated in basic sociology and gender theory.
Cass ppl never realize they are doing "rigorous assessment" based on hilarious methods. They never realize they ask people to jump without parachute before seeing "high-quality evidence", i.e. trials, that parachute reduces mortality, on average. Both methodologically and sociologically ignorant.
November 25, 2025 at 6:51 AM
Cass ppl never realize they are doing "rigorous assessment" based on hilarious methods. They never realize they ask people to jump without parachute before seeing "high-quality evidence", i.e. trials, that parachute reduces mortality, on average. Both methodologically and sociologically ignorant.
Like, ppl never talk about historicity and constructs that prevents us from (1) getting high-quality evidence and (2) generalizability and transportability of such "evidence". Like ppl always pretend that "not receiving trans care is revertible" and "don't do nothing is better than doing something".
November 25, 2025 at 6:48 AM
Like, ppl never talk about historicity and constructs that prevents us from (1) getting high-quality evidence and (2) generalizability and transportability of such "evidence". Like ppl always pretend that "not receiving trans care is revertible" and "don't do nothing is better than doing something".