I wish I could be there!
Our amazing @annarudnitsky.bsky.social will give a talk on Friday — don’t miss it!
www.nature.com/articles/s41...

The #IUIS2025 was way above my expectations! It was so great to meet old and new friends and to share our work. @iuis-online.bsky.social

Do Trojan Horse infections break tolerance to future food exposures?
No.
Unlike conventional memory T cells, dietary CD8⁺ T cells don’t expand or turn effector in response to food antigens. They return to a tolerant state—allowing safe consumption once the pathogen is gone. /13

When dietary pTreg cells are unable to instruct cDC1—either due to their absence or MHCII deletion in cDC1—dietary CD8⁺ T cells undergo massive expansion. /8

To confirm that RORγt⁺ APCs directly initiate the dietary pTreg response—and that the loss in mutant mice isn’t just due to dysbiosis—we generated mice where only RORγt⁺ APCs present antigen. These mice successfully supported pTreg induction to food. /5

We now show that antigen presentation by RORγt⁺ APCs and their expression of integrin αv, which activates TGFβ, are essential for pTreg induction to food—just as in response to the microbiota.
Deleting MHCII in RORγt⁺ APCs redirects food-specific CD4⁺ T cells to Th1/Th2/Th17/Tfh. /4

Incredible! Over the past 2 months, 5 independent manuscripts — from @TheColonnaLab, Dan Littman, @gardnerlabucsf.bsky.social and @chrysothemisbrown.bsky.social , and our own (now in @nature.com, www.nature.com/articles/s41...), reports that the dietary pTreg program is initiated by RORγt⁺ APCs. /1