The Karikari Lab
@karikarilab.bsky.social
Studying biochemical, molecular, and functional bases of neurodegenerative pathologies in the human brain and biofluids// Affiliation: University of Pittsburgh & University of Pittsburgh Medical Center // PI: Thomas K Karikari, PhD.
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We are excited to join the growing neurodegenerative research community on BlueSky and look forward to being able to see all the great work our colleagues are doing worldwide and to share some of our findings with you all! #AlzheimersResearch #science #UPITT
We're excited to welcome James Emanuel as our new Senior Research Coordinator and You-Rim Lee as a Post-Doctoral Fellow to the Karikari Lab! 🎉 We can’t wait to see the amazing contributions you'll both bring to our team. Here’s to great things ahead! 🌟 #NewBeginnings
January 10, 2025 at 9:12 PM
We're excited to welcome James Emanuel as our new Senior Research Coordinator and You-Rim Lee as a Post-Doctoral Fellow to the Karikari Lab! 🎉 We can’t wait to see the amazing contributions you'll both bring to our team. Here’s to great things ahead! 🌟 #NewBeginnings
Reposted by The Karikari Lab
In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds - Nature Neuroscience
Mice expressing humanized mutant tau exhibit synaptic loss and behavioral abnormalities in the absence of abnormal tau conformers, suggesting that hyperphosphorylated tau can be pathological, at least...
www.nature.com
January 6, 2025 at 2:13 PM
In vivo hyperphosphorylation of #tau is associated with synaptic loss and behavioral abnormalities even in the absence of tau seeds 🧪🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by The Karikari Lab
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease - Nature Neuroscience
This article discusses a puzzling issue in brain pathology: why brain-resident microglia are insufficient for protection, and why myeloid cells are needed from the periphery. Several strategies are pr...
www.nature.com
January 6, 2025 at 6:34 PM
Monocyte-derived macrophages act as reinforcements when microglia fall short in Alzheimer’s disease
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
@natureneuro.bsky.social @maabella.bsky.social
www.nature.com/articles/s41...
Congrats to our PI, Dr. Karikari for being selected for the 2025 Senior Vice Chancellor's Research Seminar Series! Don't miss his lecture on June 13th! #PittResearch #AcademicExcellence
www.health.pitt.edu/news/pitt-fa...
www.health.pitt.edu/news/pitt-fa...
Pitt Faculty Members Selected for 2025 Senior Vice Chancellor's Research Seminar Series | Health Sciences | University of Pittsburgh
Twelve Pitt faculty members have recently been selected to present their research for the 2025 Senior Vice Chancellor’s Research Seminar Series. This annual lecture series, also known as the 12@12 ser...
www.health.pitt.edu
January 6, 2025 at 8:52 PM
Congrats to our PI, Dr. Karikari for being selected for the 2025 Senior Vice Chancellor's Research Seminar Series! Don't miss his lecture on June 13th! #PittResearch #AcademicExcellence
www.health.pitt.edu/news/pitt-fa...
www.health.pitt.edu/news/pitt-fa...
Dr. Karikari has joined as an investigator on the NIH-funded Brain CHEC project, offering tailored educational interventions to Pittsburgh’s Black community to help demystify Alzheimer’s disease! #HealthEquity
health.pitt.edu/news/encoura...
health.pitt.edu/news/encoura...
Encouraging Early Intervention for Alzheimer’s in the Black Community Through an Innovative Interdisciplinary Approach | Health Sciences | University of Pittsburgh
Illustration by Hannah Lesser The data on Alzheimer’s disease in Black communities is stark: The risk is higher than average, but the rate of diagnosis is delayed. To address that, several University ...
health.pitt.edu
January 3, 2025 at 3:47 PM
Dr. Karikari has joined as an investigator on the NIH-funded Brain CHEC project, offering tailored educational interventions to Pittsburgh’s Black community to help demystify Alzheimer’s disease! #HealthEquity
health.pitt.edu/news/encoura...
health.pitt.edu/news/encoura...
The Karikari Lab reflects on a productive 2024, marked by publications, prestigious awards, and the growth of our team. We thank our lab members for driving progress, our funders for their support, and our collaborators for their partnership. Wishing you all a joyful New Year! #teamwork
January 2, 2025 at 1:18 PM
The Karikari Lab reflects on a productive 2024, marked by publications, prestigious awards, and the growth of our team. We thank our lab members for driving progress, our funders for their support, and our collaborators for their partnership. Wishing you all a joyful New Year! #teamwork
We wrapped 2024 with this a pre-print on the promising Alzheimer's disease blood biomarker p-tau217. We performed an analytical study comparing the utility of using blood processed into plasma versus into serum for p-tau217 analysis.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Equivalence of plasma and serum for clinical measurement of p-tau217: comparative analyses of four blood-based assays
Background Phosphorylated tau (p-tau) 217 is a promising blood biomarker for Alzheimer’s disease (AD). However, most p-tau217 assays have been validated solely in ethylenediaminetetraacetic acid (EDTA...
www.medrxiv.org
January 2, 2025 at 1:16 PM
We wrapped 2024 with this a pre-print on the promising Alzheimer's disease blood biomarker p-tau217. We performed an analytical study comparing the utility of using blood processed into plasma versus into serum for p-tau217 analysis.
www.medrxiv.org/content/10.1...
www.medrxiv.org/content/10.1...
Hello everyone! We are the Karikari Lab, a research laboratory at the University of Pittsburgh committed to developing innovative, simple, and accessible diagnostic biomarker tests and tools aimed at advancing the clinical management of brain disorders and enhancing patient outcomes.
January 2, 2025 at 1:12 PM
Hello everyone! We are the Karikari Lab, a research laboratory at the University of Pittsburgh committed to developing innovative, simple, and accessible diagnostic biomarker tests and tools aimed at advancing the clinical management of brain disorders and enhancing patient outcomes.