There's no reason to keep reveling in the type of manufactured complexity related to unknown & mysterious toxic entities (oligomers & whatnot), an approach that has proven impotent time & time again, while continuing to ignore such simple, basic & straightforward explanation. 2/2

A correction from @nature.com and a better explanation from UniQure are needed.
More details here: www.linkedin.com/posts/kariem... 2/2

Aggregation that leads to depletion isn't a normal immune response. The virus in the CSF is like a car in the mall, it's smashing shops that aren't there to stop moving cars, but to do other functions, they're just casualties. Immonological molecules on the other hand go up not down during infection

We think it's the depletion of important proteins due to viral presence that is more pathogenic. Unfortunately tracking protein depletion in the CSF after viral infection not yet a common diagnostic procedure

Aggregates in the brain-->⬇️Aβ42 in the CSF --> protein replacement as treatment. We shouldn't ignore such a common & treatable pathophysiological mechanism based on the irrational assumption that aggregates in neurodegeneration can only lead to disease via gain-of-function toxicity. 3/3

..-->⬇️amylin in plasma --> protein replacement as treatment. There is no reason this common pathophysiological mechanism shouldn't be extended to neurodegenerative diseases, where Alzheimer's for example should be viewed as an Aβ42 deficiency.
www.alzforum.org/alzbiomarker... 2/3

Any positive effect of Aβ42 has to be reported with expressions like "unexpectedly", "surprisingly", "strikingly", showing how skewed the perception of the field is regarding the normal positive effects of a normal neuropeptide
www.nature.com/articles/s41...
www.frontiersin.org/journals/syn... 2/2

I like Seth, but irrespective of how funny he is, it's pathetic to censor his joke out of fear

The tech bro billionaires who don't want to anger their patron, even if it were at the expense of the whole American science enterprise they pretend to care about

No worries, I understand your frustrations

It's not real I'm afraid