Kariem Ezzat
@kariemezzat.bsky.social
Co-Founder & CEO of Regain Therapeutics
#AfricanScientist
https://www.linkedin.com/in/kariem-ezzat-05708971/?originalSubdomain=se
https://pubmed.ncbi.nlm.nih.gov/?term=Kariem+Ezzat&sort=date
https://theprecipitate.blogspot.com
#AfricanScientist
https://www.linkedin.com/in/kariem-ezzat-05708971/?originalSubdomain=se
https://pubmed.ncbi.nlm.nih.gov/?term=Kariem+Ezzat&sort=date
https://theprecipitate.blogspot.com
"Trial investigators also observed a reduction in the level of a toxic protein linked to neurodegeneration in the spinal fluid of people who received the therapy." Not true, investigators reported earlier a 40% increase of mHTT in the CSF. (pic. from uniqure.gcs-web.com/news-release...) 1/2
September 26, 2025 at 11:29 AM
"Trial investigators also observed a reduction in the level of a toxic protein linked to neurodegeneration in the spinal fluid of people who received the therapy." Not true, investigators reported earlier a 40% increase of mHTT in the CSF. (pic. from uniqure.gcs-web.com/news-release...) 1/2
"frustration shapes the rose’s beauty"
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
May 2, 2025 at 1:41 PM
"frustration shapes the rose’s beauty"
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Happy that this message is finally getting across, that protein overexpression can also lead to loss of function in neurodegenerative amyloid pathologies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
April 15, 2025 at 10:50 AM
Happy that this message is finally getting across, that protein overexpression can also lead to loss of function in neurodegenerative amyloid pathologies
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A beautiful frosty morning in Stockholm showing 2ry nucleation (crystalline fibrils growing on the lateral surface of other fibrils) & demonstrating that any theory based on exclusive growth by elongation (the only way to preserve conformational information in the prion hypothesis) must be wrong.
January 4, 2025 at 11:32 AM
A beautiful frosty morning in Stockholm showing 2ry nucleation (crystalline fibrils growing on the lateral surface of other fibrils) & demonstrating that any theory based on exclusive growth by elongation (the only way to preserve conformational information in the prion hypothesis) must be wrong.