I just spent 15 minutes trying to find some critical appraisal on this trial which nobody seems talk about except the usual Vitamin-D- fans and goes against every RCT done on VitD before…

The question is whether the politician is basing his demand on scientific data alone or whether this is a grand strategy to win voters on the right and among conspiracy theorists. This study is surely not the only publication on the matter. You will also find reports that put the risk in context.

Interesting. Aortic stiffness as a surrogate for downstream vascular disease…?

Is this based on scientific data alone or a question of political strategy?

The gif is 🎯 - it’s quite obvious that if you change a daily routine (especially removing a performance-enhancing drug like caffeine) may increase stress-levels. Anybody claiming ☕️ stops afib didn’t quite get the trial.

Ah - interesting perspective!

It does seem like at least coffee is not provoking atrial fibrillation, which is something many people thought.

Haha. So true. The study claiming afternoon coffee was bad was observational and full of confounding.

Who says that?

Our LAAC patients are all patients that have stopped NOAC due to bleeding. This scenario hasn’t specifically been tested in CLOSURE but the trial does even question this situation.
Drive by occlusion - ok, then you have the procedural risks anyway, but add-on like LAAOS or instead of OAK?

Check this ad out to see how deep cardiology has fallen…

ispot.tv/a/BLi8

It seems as if it almost always works well by simply doubling their previous loop diuretic dose. But looking at the very different response curves of individual patients in this paper gives me second thoughts - maybe we need to be even more tedious?

We've been following the recomendations on initiation/dosing of furosemide (measuring excretion, not natriuesis, though) by the 2019 Mullens paper for more than 3 years in acute decomensated heart failure. ctd...

Thanks for posting this. I'm still fascinated how much there is to learn about a super-old drug like furosemide that we use every day on our hospitalised heart failure patients.

Seems like a press release. We must wait for the publication, I guess. But why not make a big drama already, I thought. 😜

#cardiosky #aha2025 #laao