Kalle Leppälä
@kallelep.bsky.social
Maybe it's just a science account? Then it's math and genetics.
The probability that a schizophrenic's polygenic score for schizophrenia is in the highest percentile is about 1.1%. The probability that Hitler's (not even schizophrenic) polygenic scores for schizophrenia, autism and bipolar are in the highest percentile each is about 0.0%.
November 26, 2025 at 2:52 PM
The probability that a schizophrenic's polygenic score for schizophrenia is in the highest percentile is about 1.1%. The probability that Hitler's (not even schizophrenic) polygenic scores for schizophrenia, autism and bipolar are in the highest percentile each is about 0.0%.
Reposted by Kalle Leppälä
The entire "free speech on campus" moral panic was manufactured to blackmail us into making space in intellectual life for bigots and charlatans who couldn't get there on their own merits. Its a DEI scheme for fascism. Congratulations to everyone who took it at face value.
“Following his lecture, Yarvin will debate the legendary British historian David Starkey on history and the future of conservatism.” Everything about this is so cursed. Masks off at the University of Oxford.
October 20, 2025 at 2:13 PM
The entire "free speech on campus" moral panic was manufactured to blackmail us into making space in intellectual life for bigots and charlatans who couldn't get there on their own merits. Its a DEI scheme for fascism. Congratulations to everyone who took it at face value.
I use Google Scholar to fetch BibTeX form citation information of articles and books, but it's not really great that capital letters in titles are not protected with curly braces, and LaTeX then renders something like genus names or "D-statistic" lower case. Come on 😤
October 6, 2025 at 8:00 AM
I use Google Scholar to fetch BibTeX form citation information of articles and books, but it's not really great that capital letters in titles are not protected with curly braces, and LaTeX then renders something like genus names or "D-statistic" lower case. Come on 😤
Reposted by Kalle Leppälä
Last year: Austin Peay State University learns prof is Nazi who went to Charlottesville rally. Admin drags heels, pays him $56k severance to leave
This week: APSU prof posts screenshot of headline - Charlie Kirk Says Gun Deaths ‘Unfortunately’ Worth it to Keep 2nd Amendment- & is immediately fired
This week: APSU prof posts screenshot of headline - Charlie Kirk Says Gun Deaths ‘Unfortunately’ Worth it to Keep 2nd Amendment- & is immediately fired
September 14, 2025 at 6:58 PM
Last year: Austin Peay State University learns prof is Nazi who went to Charlottesville rally. Admin drags heels, pays him $56k severance to leave
This week: APSU prof posts screenshot of headline - Charlie Kirk Says Gun Deaths ‘Unfortunately’ Worth it to Keep 2nd Amendment- & is immediately fired
This week: APSU prof posts screenshot of headline - Charlie Kirk Says Gun Deaths ‘Unfortunately’ Worth it to Keep 2nd Amendment- & is immediately fired
Reposted by Kalle Leppälä
Thanks @newscientist.com for shining a light on the smear campaign against @toriherridge.bsky.social, @devoevomed.bsky.social, @flintdibble.bsky.social & myself just for fulfilling our critic & conscience role to provide expert commentary about de-extinction www.newscientist.com/article/2490...
Critics of de-extinction research hit by mystery smear campaign
Several researchers who have been critical of Colossal Biosciences’ plans to revive extinct animals say they have been targeted by online articles trying to discredit them
www.newscientist.com
July 31, 2025 at 9:17 PM
Thanks @newscientist.com for shining a light on the smear campaign against @toriherridge.bsky.social, @devoevomed.bsky.social, @flintdibble.bsky.social & myself just for fulfilling our critic & conscience role to provide expert commentary about de-extinction www.newscientist.com/article/2490...
Reposted by Kalle Leppälä
After he leaked Zohran Mamdani's Columbia application data to the New York Times, critics called Jordan Lasker a "eugenicist." A Mother Jones report shows there's much more to his backstory.
Read @nlanard.bsky.social on the shocking rise of one of the tech-right’s favorite posters.
Read @nlanard.bsky.social on the shocking rise of one of the tech-right’s favorite posters.
The shocking rise of one of the tech-right’s favorite posters
After he leaked Zohran Mamdani's Columbia application data to the New York Times, critics called Jordan Lasker a "eugenicist." A Mother Jones report shows there's much more to his backstory.
www.motherjones.com
July 17, 2025 at 3:18 PM
After he leaked Zohran Mamdani's Columbia application data to the New York Times, critics called Jordan Lasker a "eugenicist." A Mother Jones report shows there's much more to his backstory.
Read @nlanard.bsky.social on the shocking rise of one of the tech-right’s favorite posters.
Read @nlanard.bsky.social on the shocking rise of one of the tech-right’s favorite posters.
Reposted by Kalle Leppälä
In a long, whiny post about a recent Atlantic article about him, white supremacist Jordan Lasker posts an incompetent analysis using the Adolescent Brain Cognitive Development (ABCD) study dataset that appears to have been illegitimately accessed and then stolen by one of his coauthors.
July 9, 2025 at 10:21 PM
In a long, whiny post about a recent Atlantic article about him, white supremacist Jordan Lasker posts an incompetent analysis using the Adolescent Brain Cognitive Development (ABCD) study dataset that appears to have been illegitimately accessed and then stolen by one of his coauthors.
Reposted by Kalle Leppälä
How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. @treebiocoe.bsky.social @erc.europa.eu 1/x 🧵 www.nature.com/articles/s41...
Plants monitor the integrity of their barrier by sensing gas diffusion - Nature
A study using Arabidopsis shows that plants can monitor the integrity of their outer barriers by sensing gas diffusion, enabling them to initiate wound repair to prevent water loss and pathogen entry.
www.nature.com
July 2, 2025 at 4:20 PM
How plants sense injury in their barrier tissue, periderm? Painstakingly detailed and amazing work by post doc Hiroyuki Iida shows that wounding is sensed by the diffusion of two gases: ethylene and oxygen. @treebiocoe.bsky.social @erc.europa.eu 1/x 🧵 www.nature.com/articles/s41...
Reposted by Kalle Leppälä
We ( @zeniabaek.bsky.social @moicoll.bsky.social and @asgerhobolth.bsky.social ) present a new cool way to visualize the optimal trade off for hmm decoding called Artemis plots!
arxiv.org/pdf/2504.15156
www.biorxiv.org/content/10.1...
arxiv.org/pdf/2504.15156
www.biorxiv.org/content/10.1...
May 5, 2025 at 1:34 PM
We ( @zeniabaek.bsky.social @moicoll.bsky.social and @asgerhobolth.bsky.social ) present a new cool way to visualize the optimal trade off for hmm decoding called Artemis plots!
arxiv.org/pdf/2504.15156
www.biorxiv.org/content/10.1...
arxiv.org/pdf/2504.15156
www.biorxiv.org/content/10.1...
Reposted by Kalle Leppälä
Patenting de-extinction. Story by @antonioregalado.bsky.social www.technologyreview.com/2025/04/16/1...
Jurassic Patent: How Colossal Biosciences is attempting to own the “woolly mammoth”
The company claiming it can restore lost species also wants to patent them.
www.technologyreview.com
April 17, 2025 at 2:53 PM
Patenting de-extinction. Story by @antonioregalado.bsky.social www.technologyreview.com/2025/04/16/1...
If someone tried to convince me that 14 edits to gray wolf genome makes the animal functionally dire wolf, I'd probably ask for a positive control: turn the wolf functionally jackal with just 14 edits. An easier task, and we at least know what jackals look like and how they act.
April 12, 2025 at 6:03 AM
If someone tried to convince me that 14 edits to gray wolf genome makes the animal functionally dire wolf, I'd probably ask for a positive control: turn the wolf functionally jackal with just 14 edits. An easier task, and we at least know what jackals look like and how they act.
My new preprint: When R ~ B(n, p) and n/k -> b > 0, then the k:th raw moment of R is asymptotically k^k (Psi +/- epsilon)^k. Earlier only upper and lower bounds of Psi existed, and a recent sharp result when n/k -> infinity. TODO: the case n/k -> 0. arxiv.org/abs/2504.05766
On raw moments of the binomial distribution
We study the $k$:th raw moment of a variable $R$ following the binomial distribution $\text{B}(n, p)$, where $n/k \rightarrow β> 0$. It is known that $\mathbb{E}(R^k)$ is bounded both from below and f...
arxiv.org
April 9, 2025 at 6:07 AM
My new preprint: When R ~ B(n, p) and n/k -> b > 0, then the k:th raw moment of R is asymptotically k^k (Psi +/- epsilon)^k. Earlier only upper and lower bounds of Psi existed, and a recent sharp result when n/k -> infinity. TODO: the case n/k -> 0. arxiv.org/abs/2504.05766
New paper out: academic.oup.com/genetics/adv...
Posterior estimation of longitudinal variance components from nonlongitudinal data using Bayesian Gaussian process model
Abstract. Many quantitative traits can be measured from a single individual only once, making acquisition of longitudinal data impossible. In this paper, w
academic.oup.com
April 3, 2025 at 8:49 AM
New paper out: academic.oup.com/genetics/adv...
Reposted by Kalle Leppälä
Scientific peer review by AI — with its own cryptocurrency! As promoted in Nature
pivot-to-ai.com/2025/03/09/s...
pivot-to-ai.com/2025/03/09/s...
Scientific peer review by AI — with its own cryptocurrency! As promoted in Nature
You might think top journal Nature telling scientists to use an LLM instead of doing proper peer review was bad enough. But how about Nature promoting schemes that say they’ll pay for AI peer revie…
pivot-to-ai.com
March 9, 2025 at 6:27 PM
Scientific peer review by AI — with its own cryptocurrency! As promoted in Nature
pivot-to-ai.com/2025/03/09/s...
pivot-to-ai.com/2025/03/09/s...
Reposted by Kalle Leppälä
It's finally official and verified: The X user "Cremieux" is ID'd as a guy called Jordan Lasker. Lasker has been LARPing as an expert in genetics on X to promote racist pseudoscience. @sashagusevposts.bsky.social has been calling out his bullshit for ages
March 3, 2025 at 9:19 PM
It's finally official and verified: The X user "Cremieux" is ID'd as a guy called Jordan Lasker. Lasker has been LARPing as an expert in genetics on X to promote racist pseudoscience. @sashagusevposts.bsky.social has been calling out his bullshit for ages
Reposted by Kalle Leppälä
So weird & inscrutable that Musk & his core ideology keeps having strong connections to eugenics & race science, including the pseudonymous race science account Cremieux revealed to be ran by Jordan Lasker whose race science paper was at the center of a scandal involving NIH data misuse & deception
US natalist conference to host race-science promoters and eugenicists
Details emerge about Natal conference in Austin later this month, set to feature figures linked to far-right politics
www.theguardian.com
March 3, 2025 at 3:52 PM
So weird & inscrutable that Musk & his core ideology keeps having strong connections to eugenics & race science, including the pseudonymous race science account Cremieux revealed to be ran by Jordan Lasker whose race science paper was at the center of a scandal involving NIH data misuse & deception
Reposted by Kalle Leppälä
Three cheers for the death of one of the last bastions of race science! (archive link so you don’t give them clicks) web.archive.org/web/20241213...
Mass resignations at the journal Intelligence
Numerous members of the editorial board resign after publisher installs new editors-in-chief.
web.archive.org
December 13, 2024 at 11:40 PM
Three cheers for the death of one of the last bastions of race science! (archive link so you don’t give them clicks) web.archive.org/web/20241213...
Reposted by Kalle Leppälä
The flat-earth paper argues that people who live further from Africa are more intelligent, but the method used to measure distance from Africa assumes the earth is flat. When this error was pointed out, nothing was done because it was a “nit-picking” criticism www.frontiersin.org/journals/com...
Frontiers | Letting the daylight in: Reviewing the reviewers and other ways to maximize transparency in science
With the emergence of online publishing, opportunities to maximize transparency of scientific research have grown considerably. However, these possibilities ...
www.frontiersin.org
December 14, 2024 at 10:30 AM
The flat-earth paper argues that people who live further from Africa are more intelligent, but the method used to measure distance from Africa assumes the earth is flat. When this error was pointed out, nothing was done because it was a “nit-picking” criticism www.frontiersin.org/journals/com...
Reposted by Kalle Leppälä
Very excited (and a bit nervous) to announce that I will be hiring two Postdocs for my new group(!) in Copenhagen to study the Neanderthal and Denisovan DNA which survives in present-day humans. Retweet will be much appreciated :)
Link for application:
candidate.hr-manager.net/ApplicationI...
Link for application:
candidate.hr-manager.net/ApplicationI...
December 2, 2024 at 12:47 PM
Very excited (and a bit nervous) to announce that I will be hiring two Postdocs for my new group(!) in Copenhagen to study the Neanderthal and Denisovan DNA which survives in present-day humans. Retweet will be much appreciated :)
Link for application:
candidate.hr-manager.net/ApplicationI...
Link for application:
candidate.hr-manager.net/ApplicationI...
Reposted by Kalle Leppälä
Final text and PDF of our new approach - Delta-statistics - to detecting directionality of admixture (introgression, hybridization) between species/populations - empirical example reanalyzes gene flow between polar and brown bears
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
Five-leaf Generalizations of the D-statistic Reveal the Directionality of Admixture
Abstract. Over the past 15 years, the D-statistic, a four-taxon test for organismal admixture (hybridization, or introgression) which incorporates single n
academic.oup.com
November 23, 2024 at 1:31 AM
Final text and PDF of our new approach - Delta-statistics - to detecting directionality of admixture (introgression, hybridization) between species/populations - empirical example reanalyzes gene flow between polar and brown bears
academic.oup.com/mbe/article/...
academic.oup.com/mbe/article/...
Reposted by Kalle Leppälä
When I was 5, I loved science, which I took to be planets and magnets and chemicals and shit.
Soon I realized science was a collective human activity, and these were just the objects of its attention.
Anyway, whenever I read an OpEd on how science isn't political, I think "Are you 5 years old?"
Soon I realized science was a collective human activity, and these were just the objects of its attention.
Anyway, whenever I read an OpEd on how science isn't political, I think "Are you 5 years old?"
November 22, 2024 at 4:32 AM
When I was 5, I loved science, which I took to be planets and magnets and chemicals and shit.
Soon I realized science was a collective human activity, and these were just the objects of its attention.
Anyway, whenever I read an OpEd on how science isn't political, I think "Are you 5 years old?"
Soon I realized science was a collective human activity, and these were just the objects of its attention.
Anyway, whenever I read an OpEd on how science isn't political, I think "Are you 5 years old?"
A new/old paper of mine just published in Annales Fennici Mathematici. I show that you can almost always row-scale a rectangular matrix so that if you were to orthonormalize the columns, the rows would attain equal Euclidean lengths in the process. afm.journal.fi/article/view...
November 14, 2024 at 11:25 AM
A new/old paper of mine just published in Annales Fennici Mathematici. I show that you can almost always row-scale a rectangular matrix so that if you were to orthonormalize the columns, the rows would attain equal Euclidean lengths in the process. afm.journal.fi/article/view...
Reposted by Kalle Leppälä
Another Guardian story on the Hope not Hate investigation into scientific racism, this time reporting that scientific racists unethically accessed UK Biobank data
‘Race science’ group say they accessed sensitive UK health data
Exclusive: Fringe network recorded boasting of securing data from UK Biobank trove donated by 500,000 volunteers
www.theguardian.com
October 17, 2024 at 4:39 PM
Another Guardian story on the Hope not Hate investigation into scientific racism, this time reporting that scientific racists unethically accessed UK Biobank data
Reposted by Kalle Leppälä
“Just as it was then, the current renaissance of eugenics and race science is nothing more than bigotry dressed up as biology” www.theguardian.com/commentisfre...
Propelled by tech money, the menace of race science is back – and it’s just as nonsensical as ever | Adam Rutherford
Once thought extinct after the fall of empire, this debunked practice has re-emerged with support from rogue experts and rich backers, says geneticist Adam Rutherford
www.theguardian.com
October 17, 2024 at 5:07 PM
“Just as it was then, the current renaissance of eugenics and race science is nothing more than bigotry dressed up as biology” www.theguardian.com/commentisfre...