Kazunari Miyamichi
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k-miyamichi.bsky.social
Kazunari Miyamichi
@k-miyamichi.bsky.social
Team leader, RIKEN BDR, Kobe, Japan https://cco.riken.jp/index_en.html; Neuroscientist studying hypothalamus and sympathetic nervous systems in mice https://scholar.google.com/citations?user=yQZ8MFgAAAAJ; Any opinions expressed herein are personal.
Pinned
The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice - Nature Communications
How individual organs are specifically regulated by the sympathetic neurons at the cellular level remains not fully understood. Here, authors identify two molecularly distinct sympathetic pathways tha...
www.nature.com
Happy to share our new work in Sci Adv! www.science.org/doi/10.1126/... We found a robust representation of pup retrieval in the orbitofrontal cortex of female mice, which positively regulates VTA dopamine neurons during the acquisition of maternal behavior. Congrats to Gen-ichi and the team!
Orbitofrontal cortex influences dopamine dynamics associated with alloparental behavioral acquisition in female mice
Orbitofrontal cortex neurons facilitate alloparental behaviors in virgin female mice by modulating the dopamine system.
www.science.org
July 2, 2025 at 7:50 PM
The new paper is out in @PLOSONE: journals.plos.org/plosone/arti.... We introduce a novel knock-in mouse line for rabies-based trans-synaptic tracing, with a detailed discussion of its strengths and limitations.
A transgenic mouse line for rabies virus-mediated trans-synaptic tracing in the postnatal developing brain
Neural circuits are composed of numerous neurons that perform diverse functions. Understanding the mechanisms of neural processing requires elucidating the connections among individual neurons. Rabies...
journals.plos.org
May 12, 2025 at 7:52 PM
If you are interested in what happens deep in the brain during puberty, please check our new paper in Neuron. We visualize how nutritional status shapes sexual maturation in female mice: A flagship study by an excellent postdoc Teppei Goto. (1/N
February 24, 2025 at 8:51 PM
If you are interested in organ sensation and organ neural control, this is the place to be! The 11th NSN in Kobe symposium will be held on February 21 at the Kobe University School of Medicine campus (and zoom). It is free but registration is required. Please come and join us!
February 5, 2025 at 3:35 AM
If you are interested in the neuroscience of lactation, here is my new review paper('ω')ノ www.sciencedirect.com/science/arti...
Oxytocin and neuroscience of lactation: Insights from the molecular genetic approach
In mammals, lactation is essential for the health and growth of infants and supports the formation of the mother–infant bond. Breastfeeding is mediate…
www.sciencedirect.com
January 22, 2025 at 5:26 AM
The placebo treatment, working simply because it is perceived as a drug, has even been observed in rats. Dr. Cui’s research investigates the neural mechanisms underlying the placebo analgesic effect, to which I contributed by supporting the RV tracing system.
www.science.org/doi/10.1126/...
Opioidergic activation of the descending pain inhibitory system underlies placebo analgesia
The placebo effect can relieve pain by activating the brain’s pain inhibition system via endogenous opioidergic signals.
www.science.org
January 16, 2025 at 5:56 AM
Reposted by Kazunari Miyamichi
new work out from the lab @cellreports.bsky.social
A brave phd student Ayano revealed the mechanism how immune activation disrupts renal tubules! The key is a nonsecretory antimicrobial peptide!
www.cell.com/cell-reports...
A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules
Using the power of Drosophila genetics, Oi et al. identified a nonsecretory antimicrobial peptide, Attacin-D, as an essential factor in inflammatory organ damage in the renal tubules. This study highlights a key player in inflammatory organ injury.
www.cell.com
December 24, 2024 at 4:11 AM
Reposted by Kazunari Miyamichi
Published! We've made a collection of knock-in strains to label endogenous active zone proteins. 'A modular system to label endogenous presynaptic proteins using split fluorophores in C. elegans' academic.oup.com/genetics/adv...
A modular system to label endogenous presynaptic proteins using split fluorophores in C. elegans
Abstract. Visualizing the subcellular localization of presynaptic proteins with fluorescent proteins is a powerful tool to dissect the genetic and molecula
academic.oup.com
December 23, 2024 at 4:07 AM
Thanks for the many citations this year🥰 The TRAP paper is experiencing a breakthrough over ten years after its publication!
Since transcriptome types and active neurons don’t always correlate in many cases, I anticipate that methods like this will continue to be useful😄
December 21, 2024 at 1:18 AM
Reposted by Kazunari Miyamichi
#83 Emo
コンディショニングの変化、Bluesky移行など。論文紹介は、valenceに応じた伝達物質放出の変化、生きた細胞からのトランスクリプトミクス、空腹による恐怖表象の変化。
#NeuroRadio #神経科学 #ポッドキャスト
neuroradio.tokyo/2024/12/21/8...
#83 Emo - NeuroRadio
ハーフマラソン参加を通じたコンディショニングの変化、Bluesky移行など。論文紹介は、valenceに応じた伝達物質放出の変化、生きた細胞からのトランスクリプトミクス、空腹による恐怖表象の変化 (12/15収録) Sh...
neuroradio.tokyo
December 21, 2024 at 12:35 AM
How do individual oxytocin neurons behave during lactation? We may not need to know this to live, but perhaps it’s how we survived infancy. If you’re interested, please check out our new paper! www.science.org/doi/10.1126/... 1/
Flexible adjustment of oxytocin neuron activity in mouse dams revealed by microendoscopy
Microendoscopic imaging reveals dynamic changes in oxytocin neuron pulsatile activity across different stages of lactation.
www.science.org
December 13, 2024 at 8:46 PM
The sympathetic nervous system may control selective organs, but how this specificity is achieved is unknown. Our new study
@NatureComms www.nature.com/articles/s41... uncovers a parallel labeled-line organization within the lower thoracic spinal cord. 1/
Parallel labeled-line organization of sympathetic outflow for selective organ regulation in mice - Nature Communications
How individual organs are specifically regulated by the sympathetic neurons at the cellular level remains not fully understood. Here, authors identify two molecularly distinct sympathetic pathways tha...
www.nature.com
December 10, 2024 at 10:55 AM
www.science.org/doi/10.1126/... I just enjoy reading this fascinating observation: the suppression of SFO putative thirst neurons in hibernating squirrels!
Suppression of neurons in circumventricular organs enables months-long survival without water in thirteen-lined ground squirrels
Water deprivation is a life-threatening condition that engages a protective physiological response to couple osmolyte retention with potentiation of thirst. This response, typical for most mammals, sa...
www.science.org
December 3, 2024 at 3:32 AM
Reposted by Kazunari Miyamichi
Our review has been out! We summarised the current view how diet, esp. amino acids, regulate ageing and lifespan. It highlights context dependency, lifestage, sex, and others, and proposes how early life nutrient signals impact longevity. Check it!
www.annualreviews.org/content/jour...
Regulatory Mechanisms of Aging Through the Nutritional and Metabolic Control of Amino Acid Signaling in Model Organisms | Annual Reviews
Life activities are supported by the intricate metabolic network that is fueled by nutrients. Nutritional and genetic studies in model organisms have determined that dietary restriction and certain mu...
www.annualreviews.org
December 3, 2024 at 12:46 AM
Happy to introduce our new preprint ('ω')ノ www.biorxiv.org/content/10.1... We have established microendoscopic imaging of individual oxytocin neurons in lactating mother mice. As lactation progresses, the waveform and intensity of individual neurons change dynamically.
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
November 25, 2024 at 2:48 AM
I am also excited about sympathetic preganglionic neurons in the spinal cord. While the classical view suggests that the sympathetic outflow systemically and uniformly regulates all organs under stressful conditions, our recent findings challenge this notion.
November 22, 2024 at 1:36 AM
I just joined this platform and am excited to share some of my scientific thoughts and achievements. Since 2018, I’ve been studying how mesoscopic neural circuits in the hypothalamus adapt and change. This brain region is key for instinctive behaviors and regulating the body’s physiology.
November 22, 2024 at 12:18 AM
Reposted by Kazunari Miyamichi
📢Register for the RIKEN BDR Symposium 2025 "Towards Redesigning Lifecycles," which will be held March 3-5, 2025 at
@BDR_RIKEN
Kobe Campus, Japan.
Participation fee: FREE (separate fees required for lunch/banquet- optional)
For details & deadlines👇
🔗https://www2.bdr.riken.jp/sympo/2025/
November 21, 2024 at 8:07 AM