Justine Silva
@justinesilva.bsky.social
UCI PhD Student👩🏻🔬| Head Lab 🧠| Studying white matter degeneration in Down syndrome🧬 | Advocate for diversity in STEM🧪
Reposted by Justine Silva
In case you missed it: the FDA cleared the first blood test to help diagnose Alzheimer’s this week.
For too long, Americans have struggled to get a simple and accurate diagnosis. This action is a step toward earlier, less invasive detection, which can lead to better access to care and treatment.
For too long, Americans have struggled to get a simple and accurate diagnosis. This action is a step toward earlier, less invasive detection, which can lead to better access to care and treatment.
First FDA-cleared Alzheimer's blood test could make diagnoses faster, more accurate
The first Alzheimer's blood test cleared by the Food And Drug Administration is poised to change the way doctors diagnose and treat the disease.
www.npr.org
May 23, 2025 at 4:51 PM
In case you missed it: the FDA cleared the first blood test to help diagnose Alzheimer’s this week.
For too long, Americans have struggled to get a simple and accurate diagnosis. This action is a step toward earlier, less invasive detection, which can lead to better access to care and treatment.
For too long, Americans have struggled to get a simple and accurate diagnosis. This action is a step toward earlier, less invasive detection, which can lead to better access to care and treatment.
Reposted by Justine Silva
Reposted by Justine Silva
When I will respond to your email
November 20, 2024 at 6:38 PM
When I will respond to your email
Reposted by Justine Silva
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research? molecularneurodegeneration.biomedcentral.com/articles/10....
November 17, 2024 at 7:49 PM
Are oligodendrocytes the missing link in Alzheimer’s disease and related dementia research? molecularneurodegeneration.biomedcentral.com/articles/10....
Reposted by Justine Silva
New starter pack: I created this one for people interested in research on #science #communication and public #engagement with science. Feel free to follow them, share the list, and suggest additions! #scicomm
go.bsky.app/3qW3UL2
go.bsky.app/3qW3UL2
November 17, 2024 at 7:57 AM
New starter pack: I created this one for people interested in research on #science #communication and public #engagement with science. Feel free to follow them, share the list, and suggest additions! #scicomm
go.bsky.app/3qW3UL2
go.bsky.app/3qW3UL2
Reposted by Justine Silva
A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable https://www.medrxiv.org/content/10.1101/2024.06.01.24308050v1
A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable https://www.medrxiv.org/content/10.1101/2024.06.01.24308050v1
In this neuropathology case report, we present findings from an individual with Down syndrome (DS) w
www.medrxiv.org
June 3, 2024 at 10:10 PM
A Neuropathology Case Report of a Woman with Down Syndrome who Remained Cognitively Stable https://www.medrxiv.org/content/10.1101/2024.06.01.24308050v1
Reposted by Justine Silva
Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroinflammation https://www.biorxiv.org/content/10.1101/2024.10.13.618101v1
Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroinflammation https://www.biorxiv.org/content/10.1101/2024.10.13.618101v1
Lewy pathology due to alpha-synuclein (-syn) inclusions is one of the major hallmarks of Parkinson D
www.biorxiv.org
October 14, 2024 at 3:15 AM
Amyloid-beta, alpha-synuclein and tau aggregated co-pathologies enhance neuropathology and neuroinflammation https://www.biorxiv.org/content/10.1101/2024.10.13.618101v1
Reposted by Justine Silva
Exploring the power of MRI and clinical measures in predicting Alzheimers disease neuropathology https://www.medrxiv.org/content/10.1101/2024.07.09.24310163v1
Exploring the power of MRI and clinical measures in predicting Alzheimers disease neuropathology https://www.medrxiv.org/content/10.1101/2024.07.09.24310163v1
Background: The ability to predict Alzheimers disease (AD) before diagnosis is a topic of intense re
www.medrxiv.org
July 10, 2024 at 5:10 PM
Exploring the power of MRI and clinical measures in predicting Alzheimers disease neuropathology https://www.medrxiv.org/content/10.1101/2024.07.09.24310163v1
Reposted by Justine Silva
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
November 15, 2024 at 2:21 PM
New work from Yasmine Kamen shows that differentiating oligodendrocytes are filled with the zymogen procaspase-3. This provides a specific marker for new oligodendrocytes and suggests a role for this pathway in oligodendrocyte fate decisions.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Justine Silva
A third study showing the OL contribution to Aβ load. The team showed -30% Aβ plaque amount (in the same range as our study and another), upregulated myelin genes in oligodendrocytes (OLs), and many new findings that expand our knowledge on amyloidogenic processing in OLs. Big congrats to the team.
Contribution of amyloid deposition from oligodendrocytes in a mouse model of Alzheimer’s disease - Molecular Neurodegeneration
Background The accumulation of β-amyloid (Aβ) peptides into insoluble plaques is an early pathological feature of Alzheimer’s disease (AD). BACE1 is the sole β-secretase for Aβ generation, making it a...
molecularneurodegeneration.biomedcentral.com
November 16, 2024 at 7:50 AM
A third study showing the OL contribution to Aβ load. The team showed -30% Aβ plaque amount (in the same range as our study and another), upregulated myelin genes in oligodendrocytes (OLs), and many new findings that expand our knowledge on amyloidogenic processing in OLs. Big congrats to the team.
Reposted by Justine Silva
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimers disease https://www.medrxiv.org/content/10.1101/2024.10.31.24316469v1
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimers disease https://www.medrxiv.org/content/10.1101/2024.10.31.24316469v1
Background All individuals with Down Syndrome (DS) will develop full-blown Alzheimer's disease (AD)
www.medrxiv.org
November 2, 2024 at 8:26 PM
Plasma p-tau212 as a biomarker of sporadic and Down Syndrome Alzheimers disease https://www.medrxiv.org/content/10.1101/2024.10.31.24316469v1
Reposted by Justine Silva
Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through Olig1/2 during Mammalian Cortical Gliogenesis and Gliomagenesis https://www.biorxiv.org/content/10.1101/2024.11.11.623106v1
Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through Olig1/2 during Mammalian Cortical Gliogenesis and Gliomagenesis https://www.biorxiv.org/content/10.1101/2024.11.11.623106v1
The hijacking of developmental gliogenesis programs is a hallmark of glioblastoma (GBM), in which gl
www.biorxiv.org
November 15, 2024 at 5:16 AM
Orchestrating the Acquisition of Oligodendrocyte Precursor Cell versus Olfactory Bulb Interneuron Fates through Olig1/2 during Mammalian Cortical Gliogenesis and Gliomagenesis https://www.biorxiv.org/content/10.1101/2024.11.11.623106v1