Julien MAMBU
@julienmambu.bsky.social
Postdoctoral researcher @kingscollegelondon.bsky.social
Reposted by Julien MAMBU
📣 March Article Award: Congrats to @julienmambu.bsky.social & team!
Their Cell paper reveals type III IFNs (IFN-λ) delay gut healing by triggering pyroptosis via ZBP1 → caspase-8 → GSDMC.
🔗https://www.cell.com/cell/abstract/S0092-8674(24)01158-9
Their Cell paper reveals type III IFNs (IFN-λ) delay gut healing by triggering pyroptosis via ZBP1 → caspase-8 → GSDMC.
🔗https://www.cell.com/cell/abstract/S0092-8674(24)01158-9
June 23, 2025 at 8:59 PM
📣 March Article Award: Congrats to @julienmambu.bsky.social & team!
Their Cell paper reveals type III IFNs (IFN-λ) delay gut healing by triggering pyroptosis via ZBP1 → caspase-8 → GSDMC.
🔗https://www.cell.com/cell/abstract/S0092-8674(24)01158-9
Their Cell paper reveals type III IFNs (IFN-λ) delay gut healing by triggering pyroptosis via ZBP1 → caspase-8 → GSDMC.
🔗https://www.cell.com/cell/abstract/S0092-8674(24)01158-9
Reposted by Julien MAMBU
Proud to share our work! 🧫😍
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
April 16, 2025 at 7:36 AM
Proud to share our work! 🧫😍
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
A special one!
Using Salmonella and Brucella, this study provides the first demonstration of an antibacterial response in pDCs orchestrated by SLAMF7 and SLAMF8, driving cytokine responses and favoring bacterial survival via mtROS control.
www.jci.org/articles/vie...
Reposted by Julien MAMBU
If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI
sign up here: zoom.us/webinar/regi...
sign up here: zoom.us/webinar/regi...
January 21, 2025 at 10:05 AM
If you want to see our work presented directly from the primary source, @julienmambu.bsky.social will be giving a free webinar on Feb 6th at 5 PM CET as part of the Thursday seminar series of the French Society of Immunology #SFI
sign up here: zoom.us/webinar/regi...
sign up here: zoom.us/webinar/regi...
Reposted by Julien MAMBU
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair
Intestinal damage following colitis or irradiation induces type III interferons (IFNs), which delay the healing of the intestinal epithelium. IFN-λ directs the sensing of Z-form nucleic acids generated during gut injury and repair, triggering cell death and altering healthy epithelial regeneration.
www.cell.com
December 26, 2024 at 5:24 PM
#EveryCellIsAnImmuneCell!💥Thrilled for the final version of our paper @cp-cell.bsky.social! We show that type III #interferons control ZBP1 activation driving gasdermin C cleavage & delaying gut repair by inducing #pyroptosis in intestinal epithelial cells! 1/n www.cell.com/cell/abstrac...
Reposted by Julien MAMBU
And finally (probably) for today, my choice this week in @science.org @lozanzi.bsky.social
10.1016/j.cell.2024.10.010
10.1016/j.cell.2024.10.010
November 30, 2024 at 8:23 AM
Reposted by Julien MAMBU
👨🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5
November 13, 2024 at 9:14 PM
👨🔬🎉Kicking off my bluesky presence by posting our lab's achievement! Our lab's first study is now out in Cell ! We show that IFN-λ induces ZBP1/CASP-8/GSDMC-dependent pyroptosis in gut epithelial cells impairing tissue repair post-colitis.#IBD #Immunology 🧵https://authors.elsevier.com/a/1k2OAL7PXqSL5
Reposted by Julien MAMBU
#newlabpic with @julienmambu.bsky.social , Amaury, Chloé, Sarah, Magda, Anissa, Franck, Virginie, and Thierno. #blessed
November 22, 2024 at 10:41 AM
#newlabpic with @julienmambu.bsky.social , Amaury, Chloé, Sarah, Magda, Anissa, Franck, Virginie, and Thierno. #blessed
Reposted by Julien MAMBU
Honored for our research conducted at @ciml.bsky.social is featured in the @cnrs.bsky.social biologie news. Shout out to @julienmambu.bsky.social for the awesome 2D #organoids image. #gastrosky #immunology #interferon
www.insb.cnrs.fr/fr/cnrsinfo/...
www.insb.cnrs.fr/fr/cnrsinfo/...
Nouvelles perspectives thérapeutiques pour les Maladies Inflammatoires Chroniques de l’Intestin
Les Maladies Inflammatoires Chroniques de l’Intestin, ou MICI, touchent plus de 250 000 personnes en France.
www.insb.cnrs.fr
November 21, 2024 at 8:05 AM
Honored for our research conducted at @ciml.bsky.social is featured in the @cnrs.bsky.social biologie news. Shout out to @julienmambu.bsky.social for the awesome 2D #organoids image. #gastrosky #immunology #interferon
www.insb.cnrs.fr/fr/cnrsinfo/...
www.insb.cnrs.fr/fr/cnrsinfo/...