Juanfe Ramirez-Contreras
@juanferamirez.bsky.social
MD and former PhD student (UdeC, CL): current GP at UBB, Ñuble, CL. MSc CogSci (CCiL at UB, ES). Posts ESP(chilean)/ENG. Interested in neuroprogression, psychiatry, mentalization/ToM, mental health
Reposted by Juanfe Ramirez-Contreras
One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation https://www.biorxiv.org/content/10.1101/2025.06.30.662293v1
July 4, 2025 at 10:16 AM
One-step induction of human GABAergic neurons promotes presynaptic development & synapse maturation https://www.biorxiv.org/content/10.1101/2025.06.30.662293v1
Reposted by Juanfe Ramirez-Contreras
In other words, #inflammaging is environmental, and that makes it modifiable. #Longevity interventions targeting this hallmark of aging could make a large impact in industrialized nations. 🧪
📰 Full (paywalled) study: www.nature.com/articles/s43...
📰 Full (paywalled) study: www.nature.com/articles/s43...
Nonuniversality of inflammaging across human populations - Nature Aging
Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...
www.nature.com
July 3, 2025 at 4:40 PM
In other words, #inflammaging is environmental, and that makes it modifiable. #Longevity interventions targeting this hallmark of aging could make a large impact in industrialized nations. 🧪
📰 Full (paywalled) study: www.nature.com/articles/s43...
📰 Full (paywalled) study: www.nature.com/articles/s43...
Reposted by Juanfe Ramirez-Contreras
Hello Bluesky friends & colleagues. I don’t normally post about my papers but thought it fitting that my first message draws attention to why I am here and not on X. A study we’ve just published on conspiracy thinking, fake news & epistemic trust: journals.plos.org/globalpublic...
The role of epistemic trust and epistemic disruption in vaccine hesitancy, conspiracy thinking and the capacity to identify fake news
Epistemic trust ‐ defined as readiness to regard knowledge, communicated by another agent, as significant, relevant to the self, and generalizable to other contexts–has recently been applied to the fi...
journals.plos.org
December 5, 2024 at 10:09 AM
Hello Bluesky friends & colleagues. I don’t normally post about my papers but thought it fitting that my first message draws attention to why I am here and not on X. A study we’ve just published on conspiracy thinking, fake news & epistemic trust: journals.plos.org/globalpublic...
“We observed increased activity with age in the posterior medial prefrontal cortex, and a combination of age-related differences and individual differences in adults in the left posterior intraparietal sulcus (IPS) and the posterior cingulate cortex”
Neural adolescent pragmatic development mirrors pragmatic differences in adulthood: an fMRI-study https://www.biorxiv.org/content/10.1101/2025.06.27.661903v1
July 3, 2025 at 2:07 PM
“We observed increased activity with age in the posterior medial prefrontal cortex, and a combination of age-related differences and individual differences in adults in the left posterior intraparietal sulcus (IPS) and the posterior cingulate cortex”
Reposted by Juanfe Ramirez-Contreras
Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning https://www.biorxiv.org/content/10.1101/2025.06.30.662421v1
July 2, 2025 at 2:15 PM
Transdiagnostic Profiles of BOLD Signal Variability in Autism and Schizophrenia Spectrum Disorders: Associations with Cognition and Functioning https://www.biorxiv.org/content/10.1101/2025.06.30.662421v1
Reposted by Juanfe Ramirez-Contreras
In multiple experimental models, a bispecific antibody _vs TCR and LAG-3) blocks T cell autoimmune disease
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Proximity between LAG-3 and the T cell receptor guides suppression of T cell activation and autoimmunity
T cell receptor proximity plays a critical role in MHC class II-dependent LAG-3 suppression
of CD4+ T cells, which disrupts the association of receptor components CD3ε/Lck inside
the cell. A bispecifi...
www.cell.com
June 30, 2025 at 2:46 PM
In multiple experimental models, a bispecific antibody _vs TCR and LAG-3) blocks T cell autoimmune disease
@cellpress.bsky.social
www.cell.com/cell/fulltex...
@cellpress.bsky.social
www.cell.com/cell/fulltex...
Reposted by Juanfe Ramirez-Contreras
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
The Somatic Mosaicism across Human Tissues Network - Nature
The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
nature.com
July 2, 2025 at 4:21 PM
We are all somatic mutation mosaics.
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
"There are trillions of cells in a human body and so the total number of somatic mutations acquired in a single individual may well exceed quadrillions, millions of times the size of the human genome."
@nature.com
nature.com/articles/s41...
Reposted by Juanfe Ramirez-Contreras
🧬 Turning regeneration back on
A new study shows mammals like mice can regrow damaged tissue - if an ancient genetic switch for retinoic acid production is reactivated.
Rabbits can do it naturally. Mice, with help, can too.
🔗 www.science.org/doi/10.1126/...
#SciComm #Regeneration 🧪
A new study shows mammals like mice can regrow damaged tissue - if an ancient genetic switch for retinoic acid production is reactivated.
Rabbits can do it naturally. Mice, with help, can too.
🔗 www.science.org/doi/10.1126/...
#SciComm #Regeneration 🧪
Reactivation of mammalian regeneration by turning on an evolutionarily disabled genetic switch
Mammals display prominent diversity in the ability to regenerate damaged ear pinna, but the genetic changes underlying the failure of regeneration remain elusive. We performed comparative single-cell ...
www.science.org
July 3, 2025 at 4:53 AM
🧬 Turning regeneration back on
A new study shows mammals like mice can regrow damaged tissue - if an ancient genetic switch for retinoic acid production is reactivated.
Rabbits can do it naturally. Mice, with help, can too.
🔗 www.science.org/doi/10.1126/...
#SciComm #Regeneration 🧪
A new study shows mammals like mice can regrow damaged tissue - if an ancient genetic switch for retinoic acid production is reactivated.
Rabbits can do it naturally. Mice, with help, can too.
🔗 www.science.org/doi/10.1126/...
#SciComm #Regeneration 🧪