Jonathan Richard
@jrichard-phd.bsky.social
Virologue (Ph. D.), mari, papa, fan du CH, CFMTL et Arsenal. Curieux de science, sport et politique /Virologist (Ph.D.), husband, dad, fan of the Habs, CFMTL, and Arsenal. Curious about science, sports, and politics.
Reposted by Jonathan Richard
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With #HIV academic.oup.com/jid/advance-... (open access) @jidjournal.bsky.social
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With HIV
Anti-gp120 CD4-induced antibodies are associated with CD4 depletion in vitro and in heavily treatment-experienced people with HIV. Fostemsavir treatment re
academic.oup.com
September 25, 2025 at 1:32 PM
Fostemsavir Decreases the Levels of Anti-gp120 CD4-Induced Antibodies in Heavily Treatment-Experienced People With #HIV academic.oup.com/jid/advance-... (open access) @jidjournal.bsky.social
40% cut would have been devastating. This is a good new in a tough year for science www.nature.com/articles/d41...
‘Congress has your back’: US senators tell scientists they want to protect NIH budget
Senate budget bill includes small increase for the health-research agency — but faces a long road before being signed into law.
www.nature.com
August 5, 2025 at 1:02 AM
40% cut would have been devastating. This is a good new in a tough year for science www.nature.com/articles/d41...
Pure classe.
The Arsenal third kit for the 2025/26 season has been officially released and it might be my favourite shirt of all time.
It’s a thing of beauty.
Take my money right now. 💰😍
It’s a thing of beauty.
Take my money right now. 💰😍
August 5, 2025 at 12:39 AM
Pure classe.
New paper out in eBioMedicine!
Non-neutralizing anti-cluster A Abs are linked to lower CD4⁺ T cell counts in PLWH on ART—likely via elimination of uninfected bystanders via ADCC
Importantly, anti-CD4 binding site Abs block this pathway and prevent this association www.thelancet.com/journals/ebi...
Non-neutralizing anti-cluster A Abs are linked to lower CD4⁺ T cell counts in PLWH on ART—likely via elimination of uninfected bystanders via ADCC
Importantly, anti-CD4 binding site Abs block this pathway and prevent this association www.thelancet.com/journals/ebi...
CD4 T cell counts are inversely correlated with anti-gp120 cluster A antibodies in antiretroviral therapy-treated PLWH
Our results reveal that anti-cluster A Abs are associated with immune dysfunction
in PLWH and anti-CD4BS antibodies might have a beneficial impact in these individuals.
www.thelancet.com
July 22, 2025 at 9:11 PM
New paper out in eBioMedicine!
Non-neutralizing anti-cluster A Abs are linked to lower CD4⁺ T cell counts in PLWH on ART—likely via elimination of uninfected bystanders via ADCC
Importantly, anti-CD4 binding site Abs block this pathway and prevent this association www.thelancet.com/journals/ebi...
Non-neutralizing anti-cluster A Abs are linked to lower CD4⁺ T cell counts in PLWH on ART—likely via elimination of uninfected bystanders via ADCC
Importantly, anti-CD4 binding site Abs block this pathway and prevent this association www.thelancet.com/journals/ebi...
Reposted by Jonathan Richard
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC https://www.biorxiv.org/content/10.1101/2024.08.27.609961v1
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC https://www.biorxiv.org/content/10.1101/2024.08.27.609961v1
HIV-1 envelope glycoproteins (Env) from primary HIV-1 isolates typically adopt a pretriggered closed
www.biorxiv.org
August 28, 2024 at 3:18 AM
The asymmetric opening of HIV-1 Env by a potent CD4 mimetic enables anti-coreceptor binding site antibodies to mediate ADCC https://www.biorxiv.org/content/10.1101/2024.08.27.609961v1
Happy to share our recent paper published in mBio. Our findings reveal that HIV-1 downmodulates CD4 prior to Env expression, making productively infected cells resistant to ADCC mediated by non-neutralizing antibodies naturally present in people living with HIV. journals.asm.org/doi/10.1128/...
CD4 downregulation precedes Env expression and protects HIV-1-infected cells from ADCC mediated by non-neutralizing antibodies | mBio
Antibody-dependent cellular cytotoxicity (ADCC) represents an effective immune response
for clearing virally infected cells, making ADCC-mediating antibodies promising therapeutic
candidates for HIV-1...
journals.asm.org
November 17, 2024 at 12:41 AM
Happy to share our recent paper published in mBio. Our findings reveal that HIV-1 downmodulates CD4 prior to Env expression, making productively infected cells resistant to ADCC mediated by non-neutralizing antibodies naturally present in people living with HIV. journals.asm.org/doi/10.1128/...