Jan Philipp Menzel
@jpmenzel.bsky.social
Scientist | Discovery of unsaturated fatty acids, LC-MS lipidomics, precision photochemistry, organic & macromolecular chemistry
Reposted by Jan Philipp Menzel
I'm so relieved to finally get this one up as a preprint. We started this project back in 2019 when we created our first gemcitabine (GEMC) resistant (GEMR) #PDAC cell line. We showed that GEMR upregulates lipid synthesis and that targeting different steps could sensitise cells to GEMC. 1/n 🧪👩🔬
Targeting de novo lipogenesis improves gemcitabine efficacy in pancreatic ductal adenocarcinoma https://www.biorxiv.org/content/10.1101/2024.12.18.628624v1
December 21, 2024 at 12:40 AM
I'm so relieved to finally get this one up as a preprint. We started this project back in 2019 when we created our first gemcitabine (GEMC) resistant (GEMR) #PDAC cell line. We showed that GEMR upregulates lipid synthesis and that targeting different steps could sensitise cells to GEMC. 1/n 🧪👩🔬
From photopolymerization (pubs.acs.org/doi/abs/10.1...) to ligation (pubs.acs.org/doi/abs/10.1...), wavelength-dependent quantum yields (www.nature.com/articles/s41...) and now photocatalysis: onlinelibrary.wiley.com/doi/10.1002/... - actions plots bring precision to photochemistry.
Introducing Photochemical Action Plots as a Tool for Unlocking On‐Off Switchable Behavior in a Polymeric Eosin Y Photocatalyst
Photochemical action plots are a powerful tool for investigating the wavelength-dependent efficiency of photochemical processes. Herein, we apply the photochemical action plot methodology developed b...
onlinelibrary.wiley.com
May 4, 2025 at 2:57 PM
From photopolymerization (pubs.acs.org/doi/abs/10.1...) to ligation (pubs.acs.org/doi/abs/10.1...), wavelength-dependent quantum yields (www.nature.com/articles/s41...) and now photocatalysis: onlinelibrary.wiley.com/doi/10.1002/... - actions plots bring precision to photochemistry.
ω-7 & ω-10 PUFA: While both can be detected in neonatal skin lipids and some cancer cells (www.nature.com/articles/s41...), the ω-7 PUFA, but no ω-10 PUFA are found in liver tissue of obese mice on a high sugar & fat diet with MASH liver disease (pubs.acs.org/doi/abs/10.1...). What is FADS2 up to?
Ozone-enabled fatty acid discovery reveals unexpected diversity in the human lipidome - Nature Communications
Fatty acids are fundamental biomolecular building blocks that are characterized by extraordinary structural diversity and present a formidable analytical challenge. Here the authors introduce a discov...
www.nature.com
April 27, 2025 at 4:13 PM
ω-7 & ω-10 PUFA: While both can be detected in neonatal skin lipids and some cancer cells (www.nature.com/articles/s41...), the ω-7 PUFA, but no ω-10 PUFA are found in liver tissue of obese mice on a high sugar & fat diet with MASH liver disease (pubs.acs.org/doi/abs/10.1...). What is FADS2 up to?
We detected omega-7 polyunsaturated fatty acids (ω-7 PUFA) in the livers of obese mice with liver disease (MASH, MC4R-KO), now published:
pubs.acs.org/doi/10.1021/...
ω-9 PUFA in membrane lipids are also elevated - potential future biomarkers?
The Skylite workflow is based on LC-MS/MS.
pubs.acs.org/doi/10.1021/...
ω-9 PUFA in membrane lipids are also elevated - potential future biomarkers?
The Skylite workflow is based on LC-MS/MS.
Skylite: Skyline-Based Lipid Isomer Retention Time Evaluation for Lipidomics in Metabolic Dysfunction-Associated Steatohepatitis
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder worldwide and can progress to steatohepatitis. Elevated de novo lipogenesis (DNL) is a key contrib...
pubs.acs.org
April 15, 2025 at 11:51 AM
We detected omega-7 polyunsaturated fatty acids (ω-7 PUFA) in the livers of obese mice with liver disease (MASH, MC4R-KO), now published:
pubs.acs.org/doi/10.1021/...
ω-9 PUFA in membrane lipids are also elevated - potential future biomarkers?
The Skylite workflow is based on LC-MS/MS.
pubs.acs.org/doi/10.1021/...
ω-9 PUFA in membrane lipids are also elevated - potential future biomarkers?
The Skylite workflow is based on LC-MS/MS.
Reposted by Jan Philipp Menzel
Skylite: Skyline-Based Lipid Isomer Retention Time Evaluation for Lipidomics in Metabolic Dysfunction-Associated Steatohepatitis #AC pubs.acs.org/doi/10.1021/...
Skylite: Skyline-Based Lipid Isomer Retention Time Evaluation for Lipidomics in Metabolic Dysfunction-Associated Steatohepatitis
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent liver disorder worldwide and can progress to steatohepatitis. Elevated de novo lipogenesis (DNL) is a key contrib...
pubs.acs.org
April 14, 2025 at 5:56 PM
Skylite: Skyline-Based Lipid Isomer Retention Time Evaluation for Lipidomics in Metabolic Dysfunction-Associated Steatohepatitis #AC pubs.acs.org/doi/10.1021/...
Reposted by Jan Philipp Menzel
@KITKarlsruhe erhält eine weitere Humboldt-Professur für den internationalen Spitzenforscher Christopher Barner-Kowollik, Experte für makromolekulare #Photochemie...
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November 25, 2024 at 9:08 AM
@KITKarlsruhe erhält eine weitere Humboldt-Professur für den internationalen Spitzenforscher Christopher Barner-Kowollik, Experte für makromolekulare #Photochemie...
weiterlesen
weiterlesen