Josh Jacobs
@joshjpharmd.bsky.social
Cardiovascular Medicine Clinical Pharmacist | Aspiring Clinician-Scientist - Cardiovascular Disease, Pharmacotherapy Optimization, Health Services Research
Reposted by Josh Jacobs
Again, PRN blood pressure medications for asymptomatic hypertension in hospitalized patients causes harm:
pubmed.ncbi.nlm.nih.gov/39585709/
pubmed.ncbi.nlm.nih.gov/39585709/
As-Needed Blood Pressure Medication and Adverse Outcomes in VA Hospitals - PubMed
The results of this retrospective cohort study showed that as-needed BP medication use among veterans is associated with increased AKI risk. The risks and benefits of this type of BP medication use wo...
pubmed.ncbi.nlm.nih.gov
January 16, 2025 at 1:35 PM
Again, PRN blood pressure medications for asymptomatic hypertension in hospitalized patients causes harm:
pubmed.ncbi.nlm.nih.gov/39585709/
pubmed.ncbi.nlm.nih.gov/39585709/
New publication co-led with Griffin Bullock!
📊 Wide variability in IV diuretic dosing for acute HF, even within a single institution.
⏱️ Delays in 1st, 2nd, & max doses = longer hospital stays. #CardioSky #PharmSKy www.sciencedirect.com/science/arti...
📊 Wide variability in IV diuretic dosing for acute HF, even within a single institution.
⏱️ Delays in 1st, 2nd, & max doses = longer hospital stays. #CardioSky #PharmSKy www.sciencedirect.com/science/arti...
Patterns of diuretic titration during inpatient management of acute decompensated heart failure
Hospitalization rates for acute decompensated heart failure (ADHF) have increased, resulting in 6.5 million hospital days annually. Despite this, opti…
www.sciencedirect.com
January 3, 2025 at 11:45 PM
New publication co-led with Griffin Bullock!
📊 Wide variability in IV diuretic dosing for acute HF, even within a single institution.
⏱️ Delays in 1st, 2nd, & max doses = longer hospital stays. #CardioSky #PharmSKy www.sciencedirect.com/science/arti...
📊 Wide variability in IV diuretic dosing for acute HF, even within a single institution.
⏱️ Delays in 1st, 2nd, & max doses = longer hospital stays. #CardioSky #PharmSKy www.sciencedirect.com/science/arti...
Reposted by Josh Jacobs
You can now watch this #JACC Journal Club's #AHA24 webinar discussing #SUMMIT CMR Substudy on Youtube
www.youtube.com/watch?v=61rd...
#CardioSky #MedSky
@chriskramermd.bsky.social @natstokes.bsky.social @jaccjournals.bsky.social @accintouch.bsky.social
www.youtube.com/watch?v=61rd...
#CardioSky #MedSky
@chriskramermd.bsky.social @natstokes.bsky.social @jaccjournals.bsky.social @accintouch.bsky.social
November 23, 2024 at 5:16 PM
You can now watch this #JACC Journal Club's #AHA24 webinar discussing #SUMMIT CMR Substudy on Youtube
www.youtube.com/watch?v=61rd...
#CardioSky #MedSky
@chriskramermd.bsky.social @natstokes.bsky.social @jaccjournals.bsky.social @accintouch.bsky.social
www.youtube.com/watch?v=61rd...
#CardioSky #MedSky
@chriskramermd.bsky.social @natstokes.bsky.social @jaccjournals.bsky.social @accintouch.bsky.social
Reposted by Josh Jacobs
Can AI automate HF adjudication in global clinical trials?
Our latest #AHA2024 SimPub
@CircHF
In the DELIVER trial, our AI model for HF hosp was
-Accurate
-Generated identical treatment estimate for dapa as human CEC
-Extracts evidence of HF
Paper: twtr.to/7qxb_
Our latest #AHA2024 SimPub
@CircHF
In the DELIVER trial, our AI model for HF hosp was
-Accurate
-Generated identical treatment estimate for dapa as human CEC
-Extracts evidence of HF
Paper: twtr.to/7qxb_
November 20, 2024 at 1:54 AM
Can AI automate HF adjudication in global clinical trials?
Our latest #AHA2024 SimPub
@CircHF
In the DELIVER trial, our AI model for HF hosp was
-Accurate
-Generated identical treatment estimate for dapa as human CEC
-Extracts evidence of HF
Paper: twtr.to/7qxb_
Our latest #AHA2024 SimPub
@CircHF
In the DELIVER trial, our AI model for HF hosp was
-Accurate
-Generated identical treatment estimate for dapa as human CEC
-Extracts evidence of HF
Paper: twtr.to/7qxb_
Reposted by Josh Jacobs
Phase 2 trial shows oral muvalaplin can lower Lp(a) levels. #AHA24 #MedSky #CardioSky
www.medscape.com/viewarticle/...
www.medscape.com/viewarticle/...
New Pill Successfully Lowers Lp(a) Levels
Muvalaplin shows promise in lowering lipoprotein(a) levels, which are genetically determined and confer cardiovascular risk and for which no approved therapies currently exist.
www.medscape.com
November 20, 2024 at 8:17 PM
Reposted by Josh Jacobs
#Spironolactone given to patients who have undergone PCI following an #AMI has no impact on ☠️ from CV causes, or on a range of CV events including new or worsening HF ( #CLEAR SYNERGY )
www.tctmd.com/news/spirono...
@shelleywood.bsky.social @shelleyzieroth.bsky.social @drrajivsankar.bsky.social
www.tctmd.com/news/spirono...
@shelleywood.bsky.social @shelleyzieroth.bsky.social @drrajivsankar.bsky.social
Spironolactone No Help for the Heart After Acute MI: CLEAR SYNERGY
(UPDATED) Part 2 of this 7,000-patient trial suffered from discontinuations and low event rates: still, early MRAs did not impact CV events.
www.tctmd.com
November 18, 2024 at 3:51 AM
What do we need to focus on de-prescribing on CVD?
Dr. Schwartz gives a good state of the field. Polypharmacy 💊💊 + age = higher complications & 💊🚫 interactions. Huge need to systematically withdrawal low-value “inappropriate” medications #AHA24 #CardioSky
Dr. Schwartz gives a good state of the field. Polypharmacy 💊💊 + age = higher complications & 💊🚫 interactions. Huge need to systematically withdrawal low-value “inappropriate” medications #AHA24 #CardioSky
November 17, 2024 at 5:02 PM
What do we need to focus on de-prescribing on CVD?
Dr. Schwartz gives a good state of the field. Polypharmacy 💊💊 + age = higher complications & 💊🚫 interactions. Huge need to systematically withdrawal low-value “inappropriate” medications #AHA24 #CardioSky
Dr. Schwartz gives a good state of the field. Polypharmacy 💊💊 + age = higher complications & 💊🚫 interactions. Huge need to systematically withdrawal low-value “inappropriate” medications #AHA24 #CardioSky
Reposted by Josh Jacobs
#AHA24 #CardioSky #MedSky
AHA @americanheart.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
AHA @americanheart.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
November 17, 2024 at 4:55 AM
#AHA24 #CardioSky #MedSky
AHA @americanheart.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
AHA @americanheart.bsky.social
ACC @accintouch.bsky.social
AHA Sciences @ahascience.bsky.social
AHA Journals @ahajournals.bsky.social
JAMA @jamacurrent.bsky.social
ASPC @aspcardio.bsky.social
Am J Prev Card @ajpcardio.bsky.social
J Card Fail @jcardfail.bsky.social
Reposted by Josh Jacobs
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
November 17, 2024 at 12:55 AM
Natural Language Processing to Adjudicate Heart Failure Hospitalizations in Global Clinical Trials
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
www.ahajournals.org/doi/10.1161/...
#Circulation #AHA24 #CardioSky #MesSky
@ahajournals.bsky.social @ahascience.bsky.social
Reposted by Josh Jacobs
CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy
www.nejm.org/doi/full/10....
#NEJM #AHA24 #CardioSky #MedSky
@ahascience.bsky.social @dramitkhera.bsky.social
www.nejm.org/doi/full/10....
#NEJM #AHA24 #CardioSky #MedSky
@ahascience.bsky.social @dramitkhera.bsky.social
CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy | NEJM
Transthyretin amyloidosis with cardiomyopathy (ATTR-CM) is a progressive, often fatal disease. Nexiguran ziclumeran (nex-z) is an investigational therapy based on CRISPR-Cas9 (clustered regularly i...
www.nejm.org
November 16, 2024 at 9:53 PM
CRISPR-Cas9 Gene Editing with Nexiguran Ziclumeran for ATTR Cardiomyopathy
www.nejm.org/doi/full/10....
#NEJM #AHA24 #CardioSky #MedSky
@ahascience.bsky.social @dramitkhera.bsky.social
www.nejm.org/doi/full/10....
#NEJM #AHA24 #CardioSky #MedSky
@ahascience.bsky.social @dramitkhera.bsky.social
Reposted by Josh Jacobs
Start Exploring! The #AHAJournals Artificial Intelligence & Precision Medicine collection pulls together articles in this emerging and important field from across the AHA portfolio of journals. #AHA24
https://www.ahajournals.org/precision-medicine
https://www.ahajournals.org/precision-medicine
November 16, 2024 at 7:39 PM
Reposted by Josh Jacobs
Lyndsey DeGroot from CU presenting findings from the ADAPT RCT! #AHA24
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
November 16, 2024 at 8:06 PM
Lyndsey DeGroot from CU presenting findings from the ADAPT RCT! #AHA24
jamanetwork.com/journals/jam...
jamanetwork.com/journals/jam...
Reposted by Josh Jacobs
Amazing @erinmichos.bsky.social teaching us about new drugs & technologies in lipid management
Love seeing 🦋 on her slides.
#AHA24 #CardioSky #MedSky #WIC
@ahascience.bsky.social @aspcardio.bsky.social @dramitkhera.bsky.social @drmarthagulati.bsky.social @minnowwalsh.bsky.social
Love seeing 🦋 on her slides.
#AHA24 #CardioSky #MedSky #WIC
@ahascience.bsky.social @aspcardio.bsky.social @dramitkhera.bsky.social @drmarthagulati.bsky.social @minnowwalsh.bsky.social
November 16, 2024 at 7:57 PM
Amazing @erinmichos.bsky.social teaching us about new drugs & technologies in lipid management
Love seeing 🦋 on her slides.
#AHA24 #CardioSky #MedSky #WIC
@ahascience.bsky.social @aspcardio.bsky.social @dramitkhera.bsky.social @drmarthagulati.bsky.social @minnowwalsh.bsky.social
Love seeing 🦋 on her slides.
#AHA24 #CardioSky #MedSky #WIC
@ahascience.bsky.social @aspcardio.bsky.social @dramitkhera.bsky.social @drmarthagulati.bsky.social @minnowwalsh.bsky.social
Reposted by Josh Jacobs
#AHA24 #CardioSky #MedSky #WIC #CardioObstetrics
Go Red For Women and Underrepresented Populations
Join us now in Main Event II
@garimasharmamd.bsky.social @ahascience.bsky.social
@minnowwalsh.bsky.social @drmarthagulati.bsky.social @dramitkhera.bsky.social
Go Red For Women and Underrepresented Populations
Join us now in Main Event II
@garimasharmamd.bsky.social @ahascience.bsky.social
@minnowwalsh.bsky.social @drmarthagulati.bsky.social @dramitkhera.bsky.social
November 16, 2024 at 7:36 PM
#AHA24 #CardioSky #MedSky #WIC #CardioObstetrics
Go Red For Women and Underrepresented Populations
Join us now in Main Event II
@garimasharmamd.bsky.social @ahascience.bsky.social
@minnowwalsh.bsky.social @drmarthagulati.bsky.social @dramitkhera.bsky.social
Go Red For Women and Underrepresented Populations
Join us now in Main Event II
@garimasharmamd.bsky.social @ahascience.bsky.social
@minnowwalsh.bsky.social @drmarthagulati.bsky.social @dramitkhera.bsky.social
Reposted by Josh Jacobs
Happening now in Main II. All about Heart Disease in women. #AHA24 #cardiosky
November 16, 2024 at 7:52 PM
Happening now in Main II. All about Heart Disease in women. #AHA24 #cardiosky
Reposted by Josh Jacobs
Dr Minc on strategies to tackle geographical disparities in #PAD “amputation hot spots” in WV using implementation science, provider ed on foot exam and #PAD, “hot foot hotline” #AHA24 #Cardiosky
November 16, 2024 at 7:48 PM
Dr Minc on strategies to tackle geographical disparities in #PAD “amputation hot spots” in WV using implementation science, provider ed on foot exam and #PAD, “hot foot hotline” #AHA24 #Cardiosky
Reposted by Josh Jacobs
Reposted by Josh Jacobs
Happening now in N226! Come explore the intersection between obesity and heart failure. What type of fat is it? 🤗🤔😀 #AHA24 #HEATAF #adipocyteheterogeneity #hotfat #standingroomonly @ahascience.bsky.social
November 16, 2024 at 7:58 PM
Happening now in N226! Come explore the intersection between obesity and heart failure. What type of fat is it? 🤗🤔😀 #AHA24 #HEATAF #adipocyteheterogeneity #hotfat #standingroomonly @ahascience.bsky.social
Reposted by Josh Jacobs
#AHA24 version of #Skytorial for #CardioSky newcomers
1/2
🦋 Unlike Twitter, liking a post does NOT promote or increase visibility of that post.
You need to REPOST.
🦋 Follow #CardioSky community by using this starter pack
go.bsky.app/562nfhZ
#MedSky
@ahascience.bsky.social
1/2
🦋 Unlike Twitter, liking a post does NOT promote or increase visibility of that post.
You need to REPOST.
🦋 Follow #CardioSky community by using this starter pack
go.bsky.app/562nfhZ
#MedSky
@ahascience.bsky.social
November 16, 2024 at 2:09 AM
#AHA24 version of #Skytorial for #CardioSky newcomers
1/2
🦋 Unlike Twitter, liking a post does NOT promote or increase visibility of that post.
You need to REPOST.
🦋 Follow #CardioSky community by using this starter pack
go.bsky.app/562nfhZ
#MedSky
@ahascience.bsky.social
1/2
🦋 Unlike Twitter, liking a post does NOT promote or increase visibility of that post.
You need to REPOST.
🦋 Follow #CardioSky community by using this starter pack
go.bsky.app/562nfhZ
#MedSky
@ahascience.bsky.social
Can health tech 💻like NLP and LLMs help with pragmatic use of clinical trials? Let’s find out! #AHA24 #CardioSky
November 16, 2024 at 8:01 PM
Can health tech 💻like NLP and LLMs help with pragmatic use of clinical trials? Let’s find out! #AHA24 #CardioSky
Important work by Dr. Jennifer Campbell & moderated by @PowellWileyLab on association btw redlining 🏠🛑 and prevalent T2DM 🍫.
Potential direct association 📈(estimate 0.28; P<0.001)
With indirect pathways through healthcare access 🏥, education 📚, & social risk ⚠️ #AHA24 #CardioSky
Potential direct association 📈(estimate 0.28; P<0.001)
With indirect pathways through healthcare access 🏥, education 📚, & social risk ⚠️ #AHA24 #CardioSky
November 16, 2024 at 7:41 PM
Important work by Dr. Jennifer Campbell & moderated by @PowellWileyLab on association btw redlining 🏠🛑 and prevalent T2DM 🍫.
Potential direct association 📈(estimate 0.28; P<0.001)
With indirect pathways through healthcare access 🏥, education 📚, & social risk ⚠️ #AHA24 #CardioSky
Potential direct association 📈(estimate 0.28; P<0.001)
With indirect pathways through healthcare access 🏥, education 📚, & social risk ⚠️ #AHA24 #CardioSky
Reposted by Josh Jacobs
Excited to see all the coverage on #AHA24! Helps reduce the fomo 😂 keep the posts coming #CardioSky
November 16, 2024 at 6:03 PM
Excited to see all the coverage on #AHA24! Helps reduce the fomo 😂 keep the posts coming #CardioSky
Reposted by Josh Jacobs
Amazing results from BPROAD trial showing lowering BP in T2DM to SBP<120 vs <140 mmHg reduces 4 points MACE HR0.79(.69-.9). Will be interesting to see how many are on SGLT2i or GLP1ra #AHA24
November 16, 2024 at 3:08 PM
Amazing results from BPROAD trial showing lowering BP in T2DM to SBP<120 vs <140 mmHg reduces 4 points MACE HR0.79(.69-.9). Will be interesting to see how many are on SGLT2i or GLP1ra #AHA24
Reposted by Josh Jacobs
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes www.nejm.org/doi/full/10....
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes | NEJM
Effective targets for systolic blood-pressure control in patients with type 2 diabetes are unclear. We enrolled patients 50 years of age or older with type 2 diabetes, elevated systolic blood press...
www.nejm.org
November 16, 2024 at 3:15 PM
Intensive Blood-Pressure Control in Patients with Type 2 Diabetes www.nejm.org/doi/full/10....