Thanks Chris - hope to chat later

Contributions from our side, Martin Proks @nazsalehin.bsky.social and Madeleine Linneberg-Agerholm, whose original in vitro finding are validated in this paper - journals.biologists.com/dev/article/...

Our model suggests that a few cells can partially differentiate, forming early endoderm that still expresses some epiblast markers - this could be due to the differences in timing of the two binary cell fate choices in preimplantation development between mouse and human.

We used our deep learning models that were originally published in www.nature.com/articles/s41...

Thanks for that !

And wait to you see the accompanying image that goes to 11!

This enhanced or deteriorating ratio of epigenetic signals may also underpin aging. Amazing work by Robert Bone @alboo87
, @molly_lowndes
and Collaborators @treebak
and Michael Nielsen, all of @LabBrickman
in @reNEW_Global
@UCPH_health

Imagine you take your grandparents to a crowded restaurant, they complain they can’t hear you both because you aren’t speaking loud enough, and that there is too much noise.

SIRT1 in turn, turns up the signal to noise ratios at the level of enhancer regulation, with 14K enhancers become 4K very effective enhancers.

Super ESCs, rejuvenated ESCs, enhanced lipid metabolism leads to elevated NAD and activated SIRT1

Essentially, we tried giving cells their own variation on Ozempic…Galactose. In the case of ESCs, we bypass the brain and substitute galactose for glucose the media…they become super stem cells.