Looking forward to Naama Barkai's visit tomorrow - all in copenhagen interested in biological specificity should come to hear her talk tomorrow!!!!

Back from the ISDB,
Clearly my presence in the lab was missed!

Imagine you take your grandparents to a crowded restaurant, they complain they can’t hear you both because you aren’t speaking loud enough, and that there is too much noise.

SIRT1 in turn, turns up the signal to noise ratios at the level of enhancer regulation, with 14K enhancers become 4K very effective enhancers.

Super ESCs, rejuvenated ESCs, enhanced lipid metabolism leads to elevated NAD and activated SIRT1

Essentially, we tried giving cells their own variation on Ozempic…Galactose. In the case of ESCs, we bypass the brain and substitute galactose for glucose the media…they become super stem cells.

Embryologists from
Amager Hvidovre Hospital visiting Brickman and @jzylicz.bsky.social labs learning about stem cell based embryo models!