Jordan Smoller
@jorsmo.bsky.social
Psychiatry, Genetics, Epidemiology, Precision Medicine. Author of The Other Side of Normal. 3% Neanderthal.
Another great post from @sashagusevposts.bsky.social "The mystery of twin heritability comes to an ignoble end: no massive tranche of rare variants, no phantom interactions, just inflation."
theinfinitesimal.substack.com/p/the-missin...
theinfinitesimal.substack.com/p/the-missin...
The missing heritability question is now (mostly) answered
Not with a bang but with a whimper
theinfinitesimal.substack.com
November 22, 2025 at 5:33 AM
Another great post from @sashagusevposts.bsky.social "The mystery of twin heritability comes to an ignoble end: no massive tranche of rare variants, no phantom interactions, just inflation."
theinfinitesimal.substack.com/p/the-missin...
theinfinitesimal.substack.com/p/the-missin...
***3 days left to sign up for our virtual conference on Precision Psychiatry***
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.
September 23, 2025 at 3:45 AM
***3 days left to sign up for our virtual conference on Precision Psychiatry***
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.
+CME +free for students and trainees.
Featuring an amazing line-up of speakers.
Reposted by Jordan Smoller
New article written by Heather Stringer about precision treatment work in the mental health space by Kate Bentley, Ellen Driessen, @jorsmo.bsky.social, Leanne Williams, Conor Liston, and others www.apa.org/monitor/2025...
www.apa.org
September 4, 2025 at 3:44 AM
New article written by Heather Stringer about precision treatment work in the mental health space by Kate Bentley, Ellen Driessen, @jorsmo.bsky.social, Leanne Williams, Conor Liston, and others www.apa.org/monitor/2025...
Ending the federal LGBTQ+ suicide prevention line is a public health failure www.statnews.com/2025/07/12/e... via @statnews.com
Ending the federal LGBTQ+ suicide prevention line is a public health failure
Ending the federal LGBTQ+ suicide prevention line is a public health failure, write two leaders in prevention and crisis response.
www.statnews.com
July 13, 2025 at 2:40 AM
Ending the federal LGBTQ+ suicide prevention line is a public health failure www.statnews.com/2025/07/12/e... via @statnews.com
The Surprising Scientists Hit by Trump’s D.E.I. Cuts www.nytimes.com/2025/07/10/u...
The Surprising Scientists Hit by Trump’s D.E.I. Cuts
www.nytimes.com
July 11, 2025 at 3:44 AM
The Surprising Scientists Hit by Trump’s D.E.I. Cuts www.nytimes.com/2025/07/10/u...
Twin study suggests genetic variation influences how funny you think you are but not how funny you actually are. 😄
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
Heritability of Humor Production Ability — A Twin Study | Twin Research and Human Genetics | Cambridge Core
Heritability of Humor Production Ability — A Twin Study
www.cambridge.org
July 10, 2025 at 1:28 PM
Twin study suggests genetic variation influences how funny you think you are but not how funny you actually are. 😄
www.cambridge.org/core/journal...
www.cambridge.org/core/journal...
New polygenic score resource from Mykyta Artomov and colleagues and @finngen.bsky.social
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."
www.medrxiv.org/content/10.1...
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."
www.medrxiv.org/content/10.1...
PGS Browser: a public platform for personalized polygenic score interpretation
Identifying individuals at elevated risk before disease onset is a cornerstone of personalized prevention, and polygenic scores (PGSs) have proven to be instrumental in this regard. In this study, we ...
www.medrxiv.org
July 6, 2025 at 3:08 PM
New polygenic score resource from Mykyta Artomov and colleagues and @finngen.bsky.social
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."
www.medrxiv.org/content/10.1...
"All data and predictive tools are accessible via the PGS Browser (pgs.nchigm.org), an interactive web-based platform for PGS analysis and interpretation."
www.medrxiv.org/content/10.1...
"career staff were told not to respond in writing to panicky grant recipients whose funding had been shut off to avoid a “paper trail,”
wapo.st/4kjmqsn
wapo.st/4kjmqsn
The first rule in Trump’s Washington: Don’t write anything down
A new culture of secrecy in government is taking root – among career staffers and new political appointees alike.
wapo.st
June 29, 2025 at 11:32 PM
"career staff were told not to respond in writing to panicky grant recipients whose funding had been shut off to avoid a “paper trail,”
wapo.st/4kjmqsn
wapo.st/4kjmqsn
Reposted by Jordan Smoller
🆕📽️Last week's webinar is available now on YouTube!
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...
Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...
Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors
YouTube video by Center for Suicide Research and Prevention (CSRP)
youtu.be
June 25, 2025 at 7:24 PM
🆕📽️Last week's webinar is available now on YouTube!
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...
Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social
How to Help a Loved One Struggling with Suicidal Thoughts and Behaviors youtu.be/TMCAikdy2dQ?...
Thank you to everyone who joined, our speakers, moderator, @jorsmo.bsky.social & @matnoc.bsky.social @afspnational.bsky.social
the disturbing old days of medicine and psychiatry in this episode of Medic from 1956:
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog
Medic - Season 2 - Episode 1 - All the Lonely Night | Richard Boone, Mary Stewart, Robert Stevenson
YouTube video by Classic TV Channel
youtu.be
June 21, 2025 at 11:11 PM
the disturbing old days of medicine and psychiatry in this episode of Medic from 1956:
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog
ulcerative colitis is caused by deep seated personality problems youtu.be/jki-rT92Uog
From back in the day when a two page research paper with no tables or references could still be transformative?
June 14, 2025 at 5:41 PM
From back in the day when a two page research paper with no tables or references could still be transformative?
Sad to see this. I used to love these numbers when I was a kid
May 31, 2025 at 2:02 AM
Sad to see this. I used to love these numbers when I was a kid
Reviewer #2 is now soliciting articles.
May 31, 2025 at 1:24 AM
Reviewer #2 is now soliciting articles.
Reposted by Jordan Smoller
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
Polygenic Scores for Schizophrenia and Educational Attainment Predict Global Functioning Across Psychiatric Hospitalization Among People with Schizophrenia
Question Is variation in global functioning among people with schizophrenia associated with genetic differences?
Findings In this genetic association study of 5991 adults with schizophrenia and 59,79...
medrxiv.org
May 23, 2025 at 3:51 PM
🚨🧬 New preprint! We tested whether PGS predicted global functioning across psychiatric hospitalization among 5991 people with schizophrenia. medrxiv.org/cgi/content/...
Reposted by Jordan Smoller
New Forbes story about the economic consequences of science cuts.
www.forbes.com/sites/johndr...
Thoughtful and thorough analysis.
1/n
www.forbes.com/sites/johndr...
Thoughtful and thorough analysis.
1/n
Trump’s NIH And NSF Cuts Estimated To Cost The U.S. Economy $10 Billion Annually
Economists find public R&D drives U.S. productivity growth — and pays for itself
www.forbes.com
May 20, 2025 at 8:28 PM
New Forbes story about the economic consequences of science cuts.
www.forbes.com/sites/johndr...
Thoughtful and thorough analysis.
1/n
www.forbes.com/sites/johndr...
Thoughtful and thorough analysis.
1/n
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment
www.nytimes.com
May 15, 2025 at 9:47 PM
Another breakthrough made possible by federal funding The result “is a triumph for the American peoples’ investment in biomedical research”
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
Baby Is Healed With World’s First Personalized Gene-Editing Treatment www.nytimes.com/2025/05/15/h...
"let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country"
What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com
What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com
What am I supposed to say to this generation of young scientists?
Undermining the future of American science is not a path to accountability — it’s a path to decline.
www.statnews.com
May 7, 2025 at 12:52 PM
"let’s be clear: It isn’t institutions that are being punished. It’s the researchers who are the future of science in this country"
What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com
What am I supposed to say to this generation of young scientists? www.statnews.com/2025/05/07/u... via @statnews.com
75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...
75% of US scientists who answered Nature poll consider leaving
More than 1,600 readers answered our poll; many said they were looking for jobs in Europe and Canada.
www.nature.com
April 1, 2025 at 3:57 PM
75% of US scientists who answered Nature poll consider leaving www.nature.com/articles/d41...
New work led by Yi-Han Sheu providing continuous-time and dynamic risk prediction models using Neuro-ODE with application to suicide risk prediction rdcu.be/eeIte
Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations
npj Digital Medicine - Continuous time and dynamic suicide attempt risk prediction with neural ordinary differential equations
rdcu.be
March 23, 2025 at 1:48 PM
New work led by Yi-Han Sheu providing continuous-time and dynamic risk prediction models using Neuro-ODE with application to suicide risk prediction rdcu.be/eeIte
JAMA 100 yrs ago: "it is generally recognized that men with large heads seem to represent the intelligentsia of man, although this does not mean necessarily that a smaller headed man may not be quite as keen in his intellectual processes."
Large and Small Brains jamanetwork.com/journals/jam...
Large and Small Brains jamanetwork.com/journals/jam...
Large and Small Brains
Apparently, mankind is prejudiced in favor of heavy brained persons. This view was bluntly expressed at a recent conference by a physician who averred that it is generally recognized that men with lar...
jamanetwork.com
March 20, 2025 at 5:58 PM
JAMA 100 yrs ago: "it is generally recognized that men with large heads seem to represent the intelligentsia of man, although this does not mean necessarily that a smaller headed man may not be quite as keen in his intellectual processes."
Large and Small Brains jamanetwork.com/journals/jam...
Large and Small Brains jamanetwork.com/journals/jam...
We Need a Reminder of What the Pre-Vaccine Era Was Like www.nytimes.com/interactive/...
Opinion | A Reminder of What Pre-Vaccine America Was Like
The worst manifestations of preventable diseases have faded from public memory.
www.nytimes.com
March 14, 2025 at 11:13 PM
We Need a Reminder of What the Pre-Vaccine Era Was Like www.nytimes.com/interactive/...
How the NIH dominates the world’s health research — in charts www.nature.com/articles/d41...
How the NIH dominates the world’s health research — in charts
Abrupt cuts by the Trump administration to the US National Institutes of Health threaten progress in medical research globally.
www.nature.com
March 13, 2025 at 9:54 PM
How the NIH dominates the world’s health research — in charts www.nature.com/articles/d41...