Jon Magne Letnes
@jonmagne.bsky.social
Cardiology resident and researcher🫀
Interests: exercise in AF (NEXAF Trial), cardiovascular physiology, sports cardiology (and mostly everything cardiology)
Interests: exercise in AF (NEXAF Trial), cardiovascular physiology, sports cardiology (and mostly everything cardiology)
In addition, I think it is intuitive that LV size could not effectively differentiate for mortality in the @mugander paper's sample as the size of the LV declines with age (mirroring decline in metabolic demand & absVO2peak, actually keeping the LVEDV/VO2 rel stable!)10/n
November 16, 2024 at 10:48 AM
In addition, I think it is intuitive that LV size could not effectively differentiate for mortality in the @mugander paper's sample as the size of the LV declines with age (mirroring decline in metabolic demand & absVO2peak, actually keeping the LVEDV/VO2 rel stable!)10/n
We showed that indexing the LVEDV to VO2peak, integrating function (or the expected output of function, VO2p) effectively differentiated between HF patients and athletes. The abs VO2peak is perfectly suited as it reflects both body size and exercise training status.9/n
November 16, 2024 at 10:41 AM
We showed that indexing the LVEDV to VO2peak, integrating function (or the expected output of function, VO2p) effectively differentiated between HF patients and athletes. The abs VO2peak is perfectly suited as it reflects both body size and exercise training status.9/n
An athlete and a HF patient with LV volumes of 250 mL would of course have very different prognosis, but no body size measure alone would ever be able to differentiate the two.
See for example how indexing the LV to BSA does not differentiate these samples at all⬇️8/n
See for example how indexing the LV to BSA does not differentiate these samples at all⬇️8/n
November 16, 2024 at 10:33 AM
An athlete and a HF patient with LV volumes of 250 mL would of course have very different prognosis, but no body size measure alone would ever be able to differentiate the two.
See for example how indexing the LV to BSA does not differentiate these samples at all⬇️8/n
See for example how indexing the LV to BSA does not differentiate these samples at all⬇️8/n
High est. cardiorespiratory fitness associated w/⬇️ risk of aortic valve stenosis requiring surgery (AVR)🫀🔪
https://academic.oup.com/ejcts/article/64/5/ezad322/7277202
No sign association to PA, but a trend of ⬆️risk of AVR in the most physically active. Several possible...
https://academic.oup.com/ejcts/article/64/5/ezad322/7277202
No sign association to PA, but a trend of ⬆️risk of AVR in the most physically active. Several possible...
November 16, 2024 at 9:35 AM
High est. cardiorespiratory fitness associated w/⬇️ risk of aortic valve stenosis requiring surgery (AVR)🫀🔪
https://academic.oup.com/ejcts/article/64/5/ezad322/7277202
No sign association to PA, but a trend of ⬆️risk of AVR in the most physically active. Several possible...
https://academic.oup.com/ejcts/article/64/5/ezad322/7277202
No sign association to PA, but a trend of ⬆️risk of AVR in the most physically active. Several possible...
New echocardiographic reference ranges of global longitudinal strain for all cardiac chambers from HUNT!
Congrats to dear colleagues, and especially @john_nyb 👏🏻 https://www.jacc.org/doi/10.1016/j.jcmg.2023.08.011
Congrats to dear colleagues, and especially @john_nyb 👏🏻 https://www.jacc.org/doi/10.1016/j.jcmg.2023.08.011
November 16, 2024 at 10:00 AM
New echocardiographic reference ranges of global longitudinal strain for all cardiac chambers from HUNT!
Congrats to dear colleagues, and especially @john_nyb 👏🏻 https://www.jacc.org/doi/10.1016/j.jcmg.2023.08.011
Congrats to dear colleagues, and especially @john_nyb 👏🏻 https://www.jacc.org/doi/10.1016/j.jcmg.2023.08.011
I think most of us have heard that the HFpEF LV is small. But is it true? I’m not sure . This figure was made for this occasion - see the explanation in the next tweet 2/ (and do hint to other relevant studies!)
November 16, 2024 at 10:25 AM
I think most of us have heard that the HFpEF LV is small. But is it true? I’m not sure . This figure was made for this occasion - see the explanation in the next tweet 2/ (and do hint to other relevant studies!)
Interestingly, in our study the mean and upper limit of normal for LVEDV/VO2peak was ~40 & ~55 ml/L/min, while data from studies on HFpEF pts having reported data on both LVEDV and absolute VO2peak show mean values consistently >65-70 mL/L/min. Implications for HFpEF diagnosis?
November 16, 2024 at 1:07 PM
Interestingly, in our study the mean and upper limit of normal for LVEDV/VO2peak was ~40 & ~55 ml/L/min, while data from studies on HFpEF pts having reported data on both LVEDV and absolute VO2peak show mean values consistently >65-70 mL/L/min. Implications for HFpEF diagnosis?
Interestingly, the LVEDV/VO2peak is relatively constant across age and sex in our material (except old men), and a literature search comparing descriptive data from other studies showed how the LVEDV/VO2peak consistently is about ~40mL/L/min.
November 16, 2024 at 12:51 PM
Interestingly, the LVEDV/VO2peak is relatively constant across age and sex in our material (except old men), and a literature search comparing descriptive data from other studies showed how the LVEDV/VO2peak consistently is about ~40mL/L/min.
Using samples of elite/recr athletes and HF patients we showed how the LVEDV/VO2peak effectively discriminated the groups contrary to LVEDV/BSA.
As the fig shows; considerable overlap for LVEDV/BSA but discrimination for LVEDV/VO2peak.
As the fig shows; considerable overlap for LVEDV/BSA but discrimination for LVEDV/VO2peak.
November 16, 2024 at 12:42 PM
Using samples of elite/recr athletes and HF patients we showed how the LVEDV/VO2peak effectively discriminated the groups contrary to LVEDV/BSA.
As the fig shows; considerable overlap for LVEDV/BSA but discrimination for LVEDV/VO2peak.
As the fig shows; considerable overlap for LVEDV/BSA but discrimination for LVEDV/VO2peak.
Using CPET + echo data from 1190🧑🤝🧑we showed a strong assoc between LVEDV and absolute VO2peak, considerably ⬆️than for BSA, and developed reference data for LVEDV/VO2peak.
November 16, 2024 at 12:34 PM
Using CPET + echo data from 1190🧑🤝🧑we showed a strong assoc between LVEDV and absolute VO2peak, considerably ⬆️than for BSA, and developed reference data for LVEDV/VO2peak.
Could indexing LVEDV to absolute VO2peak (L/min) be the 🏆in assessing LV size?
In our latest paper we show how LVEDV/VO2peak discriminates LV enlargement in heart failure from physiological enlargement in athletes. New index for heart failure diagnostics? ⬇️🧵#cardiotwitter
In our latest paper we show how LVEDV/VO2peak discriminates LV enlargement in heart failure from physiological enlargement in athletes. New index for heart failure diagnostics? ⬇️🧵#cardiotwitter
November 16, 2024 at 12:00 PM
Could indexing LVEDV to absolute VO2peak (L/min) be the 🏆in assessing LV size?
In our latest paper we show how LVEDV/VO2peak discriminates LV enlargement in heart failure from physiological enlargement in athletes. New index for heart failure diagnostics? ⬇️🧵#cardiotwitter
In our latest paper we show how LVEDV/VO2peak discriminates LV enlargement in heart failure from physiological enlargement in athletes. New index for heart failure diagnostics? ⬇️🧵#cardiotwitter
Also notable is the negligible bias between 2D and 3D LA max volume, but slightly larger 3D>2D LV volumes.
Well done and congrats to colleague Torfinn Eriksen-Volnes with the first paper of his PhD!
Well done and congrats to colleague Torfinn Eriksen-Volnes with the first paper of his PhD!
November 16, 2024 at 12:26 PM
Also notable is the negligible bias between 2D and 3D LA max volume, but slightly larger 3D>2D LV volumes.
Well done and congrats to colleague Torfinn Eriksen-Volnes with the first paper of his PhD!
Well done and congrats to colleague Torfinn Eriksen-Volnes with the first paper of his PhD!
Novel echo reference data from dedicated views in the HUNT4Echo study. Healthy sample of 1412 participants from wide age-range.
➡️larger upper normal limits for RV dimensions and LA max volumes than prior studies #OpenAccess...
➡️larger upper normal limits for RV dimensions and LA max volumes than prior studies #OpenAccess...
November 16, 2024 at 12:08 PM
Novel echo reference data from dedicated views in the HUNT4Echo study. Healthy sample of 1412 participants from wide age-range.
➡️larger upper normal limits for RV dimensions and LA max volumes than prior studies #OpenAccess...
➡️larger upper normal limits for RV dimensions and LA max volumes than prior studies #OpenAccess...
This is probably related to survival bias and the relationship between cardiorespiratory fitness and morbidity/mortality implying that those with low fitness are less likely to live until high age ➡️ leading to super-fit participants at high age in cross-sectional studies
November 16, 2024 at 1:07 PM
This is probably related to survival bias and the relationship between cardiorespiratory fitness and morbidity/mortality implying that those with low fitness are less likely to live until high age ➡️ leading to super-fit participants at high age in cross-sectional studies
Longitudinal studies have typically found progressive declines with increasing age both for relative (percentage) values and absolute (mL/kg/min) values → up to 20-25% per decade in those >70 years
November 16, 2024 at 12:59 PM
Longitudinal studies have typically found progressive declines with increasing age both for relative (percentage) values and absolute (mL/kg/min) values → up to 20-25% per decade in those >70 years
Cross-sectional studies typically show linear declines at about 10% per decade
November 16, 2024 at 12:51 PM
Cross-sectional studies typically show linear declines at about 10% per decade
What a day at work @CERG_NTNU! The Exercise in Medicine seminar packed with great talks. We even tricked the brilliant @SSharmacardio and @ThijsEijsvogels to come to Norway in mid-winter🥶❄️ for brilliant presentations on cardiac adapatations and troponin-release in athletes!
November 16, 2024 at 1:46 PM
What a day at work @CERG_NTNU! The Exercise in Medicine seminar packed with great talks. We even tricked the brilliant @SSharmacardio and @ThijsEijsvogels to come to Norway in mid-winter🥶❄️ for brilliant presentations on cardiac adapatations and troponin-release in athletes!
UNN Tromsø implanted their 1st loop-recorder in the NEXAF trial on exercise in AF yesterday! 3rd center running! NEXAF team members Fedelix & Lena did a great job💪The loop will rec AF for 4wks before CPET+randomization🏃♀️🫀 @MorsethBente @KristofferRJ89 @majalisalochen1 @NEXAF1
November 16, 2024 at 1:26 PM
UNN Tromsø implanted their 1st loop-recorder in the NEXAF trial on exercise in AF yesterday! 3rd center running! NEXAF team members Fedelix & Lena did a great job💪The loop will rec AF for 4wks before CPET+randomization🏃♀️🫀 @MorsethBente @KristofferRJ89 @majalisalochen1 @NEXAF1
Excellent presentation by my colleague @ekvesterbekkmo on effects of HIIT on coronary atheromatous plaques!
🏃🏼♀️HIIT ⬇️ atheroma volume #ESCCongress
🏃🏼♀️HIIT ⬇️ atheroma volume #ESCCongress
November 16, 2024 at 1:55 PM
Excellent presentation by my colleague @ekvesterbekkmo on effects of HIIT on coronary atheromatous plaques!
🏃🏼♀️HIIT ⬇️ atheroma volume #ESCCongress
🏃🏼♀️HIIT ⬇️ atheroma volume #ESCCongress
Busy last months, but nice to see inclusion to NEXAF trial on exercise in atrial fibrillation getting up to speed. First 40 loop recorders implanted and first patients randomised to exercise well into the intervention already! Only a few hundred more to go.. #CardioTwitter
November 16, 2024 at 2:35 PM
Busy last months, but nice to see inclusion to NEXAF trial on exercise in atrial fibrillation getting up to speed. First 40 loop recorders implanted and first patients randomised to exercise well into the intervention already! Only a few hundred more to go.. #CardioTwitter
Hadde noen bare sagt at klimakrisa ville føre til høyere skatter litt tidligere!
November 16, 2024 at 3:16 PM
Hadde noen bare sagt at klimakrisa ville føre til høyere skatter litt tidligere!
..så håper jeg strengt tatt han bruker tida si på noe viktigere.
(Okei da, sleng innom siste fem da, @almightygod! Står tross alt om VM her!)
(Okei da, sleng innom siste fem da, @almightygod! Står tross alt om VM her!)
November 16, 2024 at 3:23 PM
..så håper jeg strengt tatt han bruker tida si på noe viktigere.
(Okei da, sleng innom siste fem da, @almightygod! Står tross alt om VM her!)
(Okei da, sleng innom siste fem da, @almightygod! Står tross alt om VM her!)
Ja, det ble holdt i Paris i 2015.
November 16, 2024 at 3:36 PM
Ja, det ble holdt i Paris i 2015.