John McDonough 👊🇨🇦🍁
@johnemcd.bsky.social
I'm sure they will settle and pay a 100k fine or something.
July 24, 2025 at 7:47 PM
I'm sure they will settle and pay a 100k fine or something.
Reposted by John McDonough 👊🇨🇦🍁
Deeply grateful to all contributors; Current or former #KaminskiLab members; generous collaborators: Takis, Ivan, Melanie, Jun, the FORMIDABLE @KU_Leuven
team - Wim & Bart; and special 👏🏽👏🏽 to #SuperDuo : Schupp & Adams‼️
Fin.
#SchuppAndAdams
#CureIPF
#ScienceMatters
www.biorxiv.org/content/10.1...
team - Wim & Bart; and special 👏🏽👏🏽 to #SuperDuo : Schupp & Adams‼️
Fin.
#SchuppAndAdams
#CureIPF
#ScienceMatters
www.biorxiv.org/content/10.1...
June 15, 2025 at 1:11 PM
Deeply grateful to all contributors; Current or former #KaminskiLab members; generous collaborators: Takis, Ivan, Melanie, Jun, the FORMIDABLE @KU_Leuven
team - Wim & Bart; and special 👏🏽👏🏽 to #SuperDuo : Schupp & Adams‼️
Fin.
#SchuppAndAdams
#CureIPF
#ScienceMatters
www.biorxiv.org/content/10.1...
team - Wim & Bart; and special 👏🏽👏🏽 to #SuperDuo : Schupp & Adams‼️
Fin.
#SchuppAndAdams
#CureIPF
#ScienceMatters
www.biorxiv.org/content/10.1...
Reposted by John McDonough 👊🇨🇦🍁
5/n Taken together, our results shift the paradigmatic view of alveolar epithelial cells in IPF from ‘innocent bystanders’ to 'drivers of disease' - maybe positioning Aberrant Basaloid Cells as potential targets for cell-based therapies
#CureIPF
#PrecisionMedicine
www.biorxiv.org/content/10.1...
#CureIPF
#PrecisionMedicine
www.biorxiv.org/content/10.1...
June 15, 2025 at 1:11 PM
5/n Taken together, our results shift the paradigmatic view of alveolar epithelial cells in IPF from ‘innocent bystanders’ to 'drivers of disease' - maybe positioning Aberrant Basaloid Cells as potential targets for cell-based therapies
#CureIPF
#PrecisionMedicine
www.biorxiv.org/content/10.1...
#CureIPF
#PrecisionMedicine
www.biorxiv.org/content/10.1...
Reposted by John McDonough 👊🇨🇦🍁
@10xGenomics
Multiome analysis allowed us to establish Aberrant Basaloid Cells as a distinct lung cell population. It is different from all other lung cells and characterized by ⬆️⬆️ AP1 chromatin accessibility pattern reminiscent of Injury memory retention
#Multiome
www.biorxiv.org/content/bior...
Multiome analysis allowed us to establish Aberrant Basaloid Cells as a distinct lung cell population. It is different from all other lung cells and characterized by ⬆️⬆️ AP1 chromatin accessibility pattern reminiscent of Injury memory retention
#Multiome
www.biorxiv.org/content/bior...
June 15, 2025 at 1:11 PM
@10xGenomics
Multiome analysis allowed us to establish Aberrant Basaloid Cells as a distinct lung cell population. It is different from all other lung cells and characterized by ⬆️⬆️ AP1 chromatin accessibility pattern reminiscent of Injury memory retention
#Multiome
www.biorxiv.org/content/bior...
Multiome analysis allowed us to establish Aberrant Basaloid Cells as a distinct lung cell population. It is different from all other lung cells and characterized by ⬆️⬆️ AP1 chromatin accessibility pattern reminiscent of Injury memory retention
#Multiome
www.biorxiv.org/content/bior...
Reposted by John McDonough 👊🇨🇦🍁
3/n
To understand emergence of aberrant basaloid cells in human PCLS we did time course analysis.
Untreated PCLS -> ⬆️ alveolar epithelial diversity and proliferation suggesting
FC treated PCLS -> ⬇️ proliferation & disease like Aberrant Basaloid Cells
www.biorxiv.org/content/bior...
To understand emergence of aberrant basaloid cells in human PCLS we did time course analysis.
Untreated PCLS -> ⬆️ alveolar epithelial diversity and proliferation suggesting
FC treated PCLS -> ⬇️ proliferation & disease like Aberrant Basaloid Cells
www.biorxiv.org/content/bior...
June 15, 2025 at 1:11 PM
3/n
To understand emergence of aberrant basaloid cells in human PCLS we did time course analysis.
Untreated PCLS -> ⬆️ alveolar epithelial diversity and proliferation suggesting
FC treated PCLS -> ⬇️ proliferation & disease like Aberrant Basaloid Cells
www.biorxiv.org/content/bior...
To understand emergence of aberrant basaloid cells in human PCLS we did time course analysis.
Untreated PCLS -> ⬆️ alveolar epithelial diversity and proliferation suggesting
FC treated PCLS -> ⬇️ proliferation & disease like Aberrant Basaloid Cells
www.biorxiv.org/content/bior...
Reposted by John McDonough 👊🇨🇦🍁
2/n
Using PAGA we define distinct trajectories among ATII, ATI, Aberrant basaloid cells & ATi cells that allow identifying specific markers for intermediate states & then validate and localize the presence of ATi populations in human IPF tissue
#CTSE
www.biorxiv.org/content/10.1...
Using PAGA we define distinct trajectories among ATII, ATI, Aberrant basaloid cells & ATi cells that allow identifying specific markers for intermediate states & then validate and localize the presence of ATi populations in human IPF tissue
#CTSE
www.biorxiv.org/content/10.1...
June 15, 2025 at 1:11 PM
2/n
Using PAGA we define distinct trajectories among ATII, ATI, Aberrant basaloid cells & ATi cells that allow identifying specific markers for intermediate states & then validate and localize the presence of ATi populations in human IPF tissue
#CTSE
www.biorxiv.org/content/10.1...
Using PAGA we define distinct trajectories among ATII, ATI, Aberrant basaloid cells & ATi cells that allow identifying specific markers for intermediate states & then validate and localize the presence of ATi populations in human IPF tissue
#CTSE
www.biorxiv.org/content/10.1...
Reposted by John McDonough 👊🇨🇦🍁
1/n
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
June 15, 2025 at 1:11 PM
1/n
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
Using snRNAseq we identify a previously undiscovered population of alveolar epithelial cells in IPF - Alveolar Intermediate (ATi) cells - they share features of ATI, ATII and Aberrant Basaloid cells but also have their own distinct features.
#ATi
#CureIPF
www.biorxiv.org/content/10.1...
I think it will mean in other countries, competition for jobs will increase and holding your own job will be more difficult as can be replaced with someone better.
June 4, 2025 at 3:49 AM
I think it will mean in other countries, competition for jobs will increase and holding your own job will be more difficult as can be replaced with someone better.
These writeup are just normalization of what is happening. Giving plausible reasons for the unreasonable.
May 30, 2025 at 2:20 PM
These writeup are just normalization of what is happening. Giving plausible reasons for the unreasonable.
Great write up and exactly what I was thinking on how the conservatives have co-opted the original NDP message of serving the working class.
April 30, 2025 at 1:57 PM
Great write up and exactly what I was thinking on how the conservatives have co-opted the original NDP message of serving the working class.
Great thread but I think his career path to professor is impossible nowadays
April 25, 2025 at 12:45 PM
Great thread but I think his career path to professor is impossible nowadays
but you know the 'high-risk' work they are talking about involves injecting bleach to cure viral infections, treating covid with Ivermectin, or water memory stuff.
April 10, 2025 at 1:18 AM
but you know the 'high-risk' work they are talking about involves injecting bleach to cure viral infections, treating covid with Ivermectin, or water memory stuff.
And the shooter was known to be a one of worst at being able to hit the target.
April 2, 2025 at 1:45 AM
And the shooter was known to be a one of worst at being able to hit the target.
What did we do in the 2018?
April 2, 2025 at 1:36 AM
What did we do in the 2018?
This is I think higher than his previous poll. So I can’t see anything changing.
March 30, 2025 at 11:35 PM
This is I think higher than his previous poll. So I can’t see anything changing.
If you like anime. Watch frieren.
March 29, 2025 at 4:55 AM
If you like anime. Watch frieren.
I’m watching The Rookie. Not deep but shows people trying to do good. Also has Nathan Fillion
March 29, 2025 at 3:13 AM
I’m watching The Rookie. Not deep but shows people trying to do good. Also has Nathan Fillion
This is just to isolate Canada to annex us. I really think this is Elon's idea to be able to become president.
March 27, 2025 at 4:24 PM
This is just to isolate Canada to annex us. I really think this is Elon's idea to be able to become president.
Sure but why alienate all the voters who saw Trudeau policies as a failure. Easy to find another liberal candidate and not risk being painted as Trudeau 2.0
March 26, 2025 at 7:19 AM
Sure but why alienate all the voters who saw Trudeau policies as a failure. Easy to find another liberal candidate and not risk being painted as Trudeau 2.0
This says to basically get a burner phone and laptop. Yeah I’ll probably just not go for a while.
March 26, 2025 at 4:21 AM
This says to basically get a burner phone and laptop. Yeah I’ll probably just not go for a while.
Sorry but I think this is a mistake. Two biggest faults of Trudeau were immigration and housing and Fraser was the face of both. This will hurt you in the long run. I would have replaced him to show break from previous government
March 26, 2025 at 3:00 AM
Sorry but I think this is a mistake. Two biggest faults of Trudeau were immigration and housing and Fraser was the face of both. This will hurt you in the long run. I would have replaced him to show break from previous government
Why? I thought he screwed up the immigration and housing portfolios and is the face of everything that went wrong with the Trudeau government. Think it was a major mistake to bring him back.
March 26, 2025 at 2:53 AM
Why? I thought he screwed up the immigration and housing portfolios and is the face of everything that went wrong with the Trudeau government. Think it was a major mistake to bring him back.