Joe Fisher
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joemlfisher.bsky.social
Joe Fisher
@joemlfisher.bsky.social
17 followers 39 following 2 posts
Third year PhD student in UCD 🎓
Researching the future of high energy astrophysical missions 🔭🛰️
He/Him 🪴
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oysterbythesea.bsky.social
Starting my migration process from X
November 15, 2024 at 10:52 AM
Reposted by Joe Fisher
lucygdornan.bsky.social
🧪 Excited to see this go live today! We wrote a Preview article exploring the stunning work by Lacoste, Haghighi and colleagues @drannecarpenter.bsky.social @shantanuxsingh.bsky.social @mike_tilapia in the latest edition of Cell.

doi.org/10.1016/j.xg...
This image portrays a graphical abstract for the Cell Genomics Preview article by Dornan & Simpson (2024). This graphical abstract summarises the workflow and key findings of a research paper by Lacoste, Haghighi and colleagues in the most recent edition of Cell. In summary, 3,448 variants from a collection of 1,269 genes were GFP-tagged and transfected into cells. Using high-content screening microscopy, the researchers identified that improper localisation of proteins encoded by the gene variants accounted for a huge 16% of all pathogenic variants studied. Upon further investigation, they also found that mislocalisation correlated with disease severity, and that mislocalised proteins also tended to be unstable and misfolded. This work has highlighted the importance of correct protein localisation, and developed a highly effective and useful screening system for the identification of mislocalised proteins which has huge implications for alternative and innovative drug discovery methods.
November 13, 2024 at 8:30 PM
joemlfisher.bsky.social
Downloaded bsky app to my phone this morning and saw it was #2 in the Social Media charts on the app store (in Ireland) - so out of curiosity I wanted to see where X was… #2 in the News chart?? Make it make sense 🤯 Above RTÉ news??
November 13, 2024 at 9:07 AM
joemlfisher.bsky.social
I've been on this platform for only 5 minutes and I can already see the stark difference between it and Twitter/X - amazing vibes here 🤩
November 12, 2024 at 11:20 PM