Joe Loo
@joelooucla.bsky.social
UCLA Department of Chemistry and Biochemistry. Better living through mass spectrometry.
Reposted by Joe Loo
The Field and Franklin Award for Mass Spectrometry is back! Since 1985, this award has recognize outstanding achievement in the development or application of #massspec #teammassspec. Please submit nominations by November 14! Nomination details: acsanalytical.org/awards-resou...
Division of Analytical Chemistry Awards
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acsanalytical.org
November 1, 2025 at 4:32 PM
The Field and Franklin Award for Mass Spectrometry is back! Since 1985, this award has recognize outstanding achievement in the development or application of #massspec #teammassspec. Please submit nominations by November 14! Nomination details: acsanalytical.org/awards-resou...
I almost forgot about this "oldie but a goodie" paper published in 1994. It might be one of the first ones showing the use of variable-temperature ESI to measure the thermodynamics of non-covalent binding of a protein to a peptide (native MS). The first author was a young @goodlettlabb.bsky.social
(JASMS) [ASAP] Correction to ″A study of the thermal denaturation of ribonuclease S by electrospray ionization mass spectrometry″: Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00331 (RSS) #MassSpecRSS #JASMS
[ASAP] Correction to ″A study of the thermal denaturation of ribonuclease S by electrospray ionization mass spectrometry″
Journal of the American Society for Mass SpectrometryDOI: 10.1021/jasms.5c00331
dlvr.it
October 20, 2025 at 6:47 PM
I almost forgot about this "oldie but a goodie" paper published in 1994. It might be one of the first ones showing the use of variable-temperature ESI to measure the thermodynamics of non-covalent binding of a protein to a peptide (native MS). The first author was a young @goodlettlabb.bsky.social
Great meeting to get a "top-down" view of how mass spectrometry and microscopy can merge to "see" large biological molecules. Can't wait for the next version of MS + M, wherever and whenever it's held.
October 3, 2025 at 6:08 AM
Great meeting to get a "top-down" view of how mass spectrometry and microscopy can merge to "see" large biological molecules. Can't wait for the next version of MS + M, wherever and whenever it's held.
Reposted by Joe Loo
(J Am Chem Soc) [ASAP] Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry: Journal of the American Chemical SocietyDOI: 10.1021/jacs.5c05797 #JAmChemSoc #MassSpecRSS
[ASAP] Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry
Journal of the American Chemical SocietyDOI: 10.1021/jacs.5c05797
dlvr.it
September 24, 2025 at 7:04 PM
(J Am Chem Soc) [ASAP] Retention and Rearrangement of Membrane Protein Complexes’ Higher Order Structure by Collisionally Activated Dissociation- and Electron Capture Dissociation-Mass Spectrometry: Journal of the American Chemical SocietyDOI: 10.1021/jacs.5c05797 #JAmChemSoc #MassSpecRSS
Hey, ASMSers @asms.org , did you see Jack Henion, our new Fenn Distinguished Contribution Awardee, on HBO's The Mortician tonight? He briefly talked about trying to detect a poison, oleandrin, from a corpse during his #ASMS2025 talk. You'll have to watch the show to find out whether he did or not.
June 16, 2025 at 4:58 AM
Here’s our tiny MALDI-8020 we installed earlier this year. Also the first Shimadzu MS in my life. So far, so good.
June 13, 2025 at 2:49 PM
Here’s our tiny MALDI-8020 we installed earlier this year. Also the first Shimadzu MS in my life. So far, so good.
Consider signing the letter to support NIH and the "Bethesda Declaration" (www.standupforscience.net/bethesda-dec...) #ASMS2025 @asms.org
June 9, 2025 at 4:01 PM
Consider signing the letter to support NIH and the "Bethesda Declaration" (www.standupforscience.net/bethesda-dec...) #ASMS2025 @asms.org
Fun last day session at #ASMS2025 organized by @lingjun2025.bsky.social on Fundamentals of Native MS. Hopefully for #ASMS2026 we’ll start a tradition of a final toast after the last Thursday PM oral sessions.
June 7, 2025 at 2:01 AM
Fun last day session at #ASMS2025 organized by @lingjun2025.bsky.social on Fundamentals of Native MS. Hopefully for #ASMS2026 we’ll start a tradition of a final toast after the last Thursday PM oral sessions.
Oh, oh……
BTW, thanks Kevin for pointing out the 73nd xD
June 5, 2025 at 10:30 AM
Oh, oh……
I wonder how many ASMSers are at the ball game today (Sunday). Raise your hand if you're cheering on the Orioles! And don't forget to come back for the tutorials, opening plenary, and evening reception. #ASMS2025
June 1, 2025 at 6:29 PM
I wonder how many ASMSers are at the ball game today (Sunday). Raise your hand if you're cheering on the Orioles! And don't forget to come back for the tutorials, opening plenary, and evening reception. #ASMS2025
Fun project to be a part of….cryoEM combined with native MS and native top-down MS helps to elucidate the function of this protein complex
(BioRxiv All) Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase: A major type of spontaneous protein damage that accumulates with age is the formation of kinked polypeptide chains with L-isoaspartyl residues.… #BioRxiv #MassSpecRSS
Structural basis for L-isoaspartyl-containing protein recognition by the PCMTD1 cullin-RING E3 ubiquitin ligase
A major type of spontaneous protein damage that accumulates with age is the formation of kinked polypeptide chains with L-isoaspartyl residues. Mitigating this damage is necessary for maintaining proteome stability and prolonging organismal survival. While repair through methylation by PCMT1 has been previously shown to suppress L-isoaspartyl accumulation, we provide an additional mechanism for L-isoaspartyl maintenance through PCMTD1, a cullin-RING ligase (CRL). We combined cryo-EM, native mass spectrometry, and biochemical assays to provide insight on how the assembly and architecture of PCMTD1 in the context of a CRL complex fulfils this alternative mechanism. We show that the PCMTD1 CRL complex specifically binds L-isoaspartyl residues when bound to AdoMet. This work provides evidence for a growing class of E3 ubiquitin ligases that recognize spontaneous covalent modifications as potential substrates for ubiquitylation and subsequent proteasomal degradation.
dlvr.it
May 22, 2025 at 2:19 PM
Fun project to be a part of….cryoEM combined with native MS and native top-down MS helps to elucidate the function of this protein complex
The longer version of my comments can be found here: theanalyticalscientist.com/issues/2025/... I encourage all to remain engaged with the science enterprise. Come to the upcoming ASMS conference to engage fully in our shared scientific pursuits. @asms.org
May 20, 2025 at 10:42 PM
The longer version of my comments can be found here: theanalyticalscientist.com/issues/2025/... I encourage all to remain engaged with the science enterprise. Come to the upcoming ASMS conference to engage fully in our shared scientific pursuits. @asms.org
Reposted by Joe Loo
Interested in learning #TopDownProteomics, join us for a @asms.org Short Course on Top-Down Proteomics! Had a very successful course over the past 3 years, and excited to offer it again this year. Don’t miss out – register early! Early registration ends April 30. www.asms.org/conferences/...
April 22, 2025 at 1:00 PM
Interested in learning #TopDownProteomics, join us for a @asms.org Short Course on Top-Down Proteomics! Had a very successful course over the past 3 years, and excited to offer it again this year. Don’t miss out – register early! Early registration ends April 30. www.asms.org/conferences/...
What could be better than Hawaii in December? Dive into some exciting discussions on top-down proteomics and proteoform analysis at Pacifichem 2025 for the session #ANA016. Abstract submissions are still open until April 2! @proteoforms.bsky.social @nlkproteomics.bsky.social @jyates.bsky.social
February 25, 2025 at 5:31 AM
What could be better than Hawaii in December? Dive into some exciting discussions on top-down proteomics and proteoform analysis at Pacifichem 2025 for the session #ANA016. Abstract submissions are still open until April 2! @proteoforms.bsky.social @nlkproteomics.bsky.social @jyates.bsky.social
Last week was busy for the ASMS Board, meeting in Santa Fe to plan for the 2025 ASMS annual conf in Baltimore. After 3-days, we were looking pretty tired and grumpy (left), but the thought of #ASMS2025 cheered us up (right). Check out the Asilomar, Winter conf, and Fall Workshop topics @asms.org.
February 3, 2025 at 6:12 AM
Happy holidays from the Loo group at UCLA. It's been an eventful year - some people leaving (graduating, making tons of $$), and new students joining. Next year promises to be equally busy and fun. "Nothin' but blue skies from now on...". Wishing all a peaceful 2025.
December 23, 2024 at 7:32 PM
Happy holidays from the Loo group at UCLA. It's been an eventful year - some people leaving (graduating, making tons of $$), and new students joining. Next year promises to be equally busy and fun. "Nothin' but blue skies from now on...". Wishing all a peaceful 2025.
Last day on the frozen lake @lakelouisemsms.bsky.social . Had a wonderful time seeing all the great mass spec science in a beautiful setting. #LakeLouise2024 is a wrap. Can’t wait for next year.
December 7, 2024 at 11:36 PM
Last day on the frozen lake @lakelouisemsms.bsky.social . Had a wonderful time seeing all the great mass spec science in a beautiful setting. #LakeLouise2024 is a wrap. Can’t wait for next year.
Had to walk on a frozen lake @lakelouisemsms.bsky.social to get a shot of blue sky to post on BlueSky #LakeLouise2024
December 6, 2024 at 10:10 PM
Had to walk on a frozen lake @lakelouisemsms.bsky.social to get a shot of blue sky to post on BlueSky #LakeLouise2024
Goes with the talk by @erinbakerims.bsky.social on mass spec of poop. 💩
I think some might appreciate this spectacular view of the majestic and timeless scenery at the Lake Louise mass spectrometry conference. #LakeLouise2024
December 6, 2024 at 3:32 PM
Goes with the talk by @erinbakerims.bsky.social on mass spec of poop. 💩
First attempt - "Sassy" (short for Sasquatch) #LakeLouise2024
Our little #LakeLouise2024 yeti mascot needs a name. Please comment with your favorite name and if it is picked, it will be going home with you. If you are participating from afar and your name is picked, we can probably make one fly your way.
December 5, 2024 at 9:49 PM
First attempt - "Sassy" (short for Sasquatch) #LakeLouise2024