Joe Frost
@joefrost.bsky.social
Postdoctoral immunologist MSKCC Rudensky lab Tregs and inflammation // previously iron and immunity at Drakesmith lab University of Oxford
Reposted by Joe Frost
It was fun to make this with our fabulous collaborators!
📽️ Check out our latest video, where we speak with the @drakesmith-lab.bsky.social and their collaborators in @oxuniearthsci.bsky.social & @biology.ox.ac.uk to find out how they're tackling iron deficiency - the world's most common nutritional deficiency 🧪
@rdm.ox.ac.uk | @ox.ac.uk
Watch here 👇
@rdm.ox.ac.uk | @ox.ac.uk
Watch here 👇
Tackling Iron Deficiency
YouTube video by MRC Weatherall Institute of Molecular Medicine
www.youtube.com
September 17, 2025 at 10:08 AM
It was fun to make this with our fabulous collaborators!
Reposted by Joe Frost
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
September 5, 2025 at 6:53 PM
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻♀️
Reposted by Joe Frost
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Iron and the immune system - Nature Reviews Immunology
Iron is crucial for cellular metabolism, but its availability varies greatly within and between individuals and populations. This Review highlights how iron regulates innate and adaptive cellular and ...
www.nature.com
June 23, 2025 at 4:10 PM
2 new efforts: from Megan Teh on metabolism of CD8 Tcells in iron deficiency and why they love aspartate (+ @sarahdimeloe.bsky.social @lindavsinclair.bsky.social); & reviewing the strong influence of iron on immunity @joefrost.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Joe Frost
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...
Ancient genomic linkage of α-globin and Nprl3 couples metabolism with erythropoiesis - Nature Communications
Nprl3 controls erythroblast metabolism and is upregulated by α -globin enhancers sited within its introns. This arrangement couples metabolic and developmental control during erythropoiesis and may ex...
www.nature.com
March 24, 2025 at 1:24 PM
Wonderful to see this out, a big effort led by Alexandra Preston and fun for the lab to do something new (and very very old); plus it’s only slightly iron-related! 😳😱😀 www.nature.com/articles/s41...