Joe Curran
@joecurran1.bsky.social
PhD student in the Nurse Lab @crick.ac.uk 👨🏻🔬 Interested in information processing in biology 🧬 Currently chasing a tiny protein around the cell cycle 🔬 Believer that science is for everyone 🌍
Reposted by Joe Curran
New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.
Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme
Nature Chemistry - Models of abiotic RNA replication suffer from inherent product inhibition arising from the high stability of RNA duplexes. Now, it has been shown that RNA trinucleotide...
rdcu.be
May 29, 2025 at 3:55 PM
New paper from my group rdcu.be/eoaRr "Trinucleotide substrates under pH–freeze–thaw cycles enable open-ended exponential RNA replication by a polymerase ribozyme" in Nature Chemistry — great collaboration with attwaterlab.uk.
The latest preprint from our lab is out! 🎉 A phosphoproteomic adventure into how different phosphatases counteract CDK activity and how this can help to order substrate phosphorylation during the cell cycle. Find out more from first author, and my PhD lab partner in crime @theresazeisner.bsky.social
🚨New preprint🚨
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
How do phosphatases affect CDK substrate phosphorylation timing during the cell cycle?
We showed that substrates dephosphorylated by different Ppases are net phosphorylated at different times.
📖 Read here: doi.org/10.1101/2025... & follow along for some key insights 🧵
February 25, 2025 at 4:51 PM
The latest preprint from our lab is out! 🎉 A phosphoproteomic adventure into how different phosphatases counteract CDK activity and how this can help to order substrate phosphorylation during the cell cycle. Find out more from first author, and my PhD lab partner in crime @theresazeisner.bsky.social
Reposted by Joe Curran
Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
A map of the rubisco biochemical landscape - Nature
A massively parallel assay developed to map the essential photosynthetic enzyme rubisco showed that non-trivial biochemical changes and improvements in CO2 affinity are possible, signposting further e...
www.nature.com
January 22, 2025 at 9:17 PM
Every synthetic biologist, every biochemist, when they dream, will sometimes hear a voice calling
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
A whisper on the wind, as impossible as infinity, as sweet as the ambrosia of the very Gods
"...engineer RuBisCo..."
And this paper takes us one step closer
www.nature.com/articles/s41...
Reposted by Joe Curran
Hello! Just thought I'd introduce myself here. I am a biophysicist and postdoctoral fellow in the Paul Nurse lab at the Crick Institute, where I have been investigating spatiotemporal principles in cell transitions (CDK activation, bistability, signal propagation).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Spatiotemporal Orchestration of Mitosis by Cyclin-Dependent Kinase
Mitotic onset is a critical transition for eukaryotic cell proliferation. The prevailing view for its control is that cyclin-dependent kinase (CDK) is activated first in the cytoplasm, at the centroso...
www.biorxiv.org
November 22, 2024 at 10:55 AM
Hello! Just thought I'd introduce myself here. I am a biophysicist and postdoctoral fellow in the Paul Nurse lab at the Crick Institute, where I have been investigating spatiotemporal principles in cell transitions (CDK activation, bistability, signal propagation).
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Hi #SciSky! It’s exciting to see that we’ve reached a critical mass and it’s all kicking off here. Looking forward to finding out about lots of cool science
November 15, 2024 at 9:18 AM
Hi #SciSky! It’s exciting to see that we’ve reached a critical mass and it’s all kicking off here. Looking forward to finding out about lots of cool science